ChatGPTを活用して業務のAI化を進めています。プロンプトエンジニアリングの専門家です！と、名乗れるレベルではありませんが、かなり色々使いこなしてきています。この１年、病気で失われた能力は、別な能力を発達させる、進化することで生き残っていこうと思います。
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24/02/08
Anoikis and SPP1 in idiopathic pulmonary fibrosis: integrating bioinformatics, cell, and animal studies to explore prognostic biomarkers and PI3K/AKT Signaling …
Y Liao, Y Yang, G Zhou, L Chen, Y Yang, S Guo, Q Zuo… - Expert Review of Clinical …, 2024
… This study aims to explore the relevance of anoikis in idiopathic pulmonary fibrosis (IPF) and identify associated biomarkers and signaling … Single- vs double-lung transplantation in patients with chronic obstructive pulmonary disease and idiopathic …
- 特発性肺線維症におけるアノイキスと SPP1: バイオインフォマティクス、細胞、動物研究を統合して、予後バイオマーカーと PI3K/AKT シグナル伝達制御を探索
[HTML] Targeting Progression in Pulmonary Fibrosis: An Overview of Underlying Mechanisms, Molecular Biomarkers, and Therapeutic Intervention
V D'Agnano, DF Mariniello, M Ruotolo, G Quarcio… - Life, 2024
… of diffuse lung disorders, potentially resulting in pulmonary fibrosis. While idiopathicpulmonary fibrosis has been recognized as the paradigm of … Thus, understanding the common pathways that induce the progression of pulmonary …
- 肺線維症の進行を標的とする: 根底にあるメカニズム、分子バイオマーカー、および治療介入の概要
[PDF] Multiomic Analysis of Monocyte-Derived Alveolar Macrophages in Idiopathic Pulmonary Fibrosis
M Zhang, J Zhang, H Hu, Y Zhou, ZW Lin, H Jing… - 2024
… Using multiomics analysis, we aim to delineate the effects of Mo_AMs on the development of IPF. Our study reveals the cellular … of IPF, our ndings demonstrated fewer alveolar epithelial cells in the IPF group compared to the control …
- 特発性肺線維症における単球由来肺胞マクロファージのマルチオーム解析
Phœnix dactylifera, L. seed oil alleviates Bleomycin-induced pulmonary fibrosis and oxidative stress in Wistar rats
S Bahri, R Abdennabi, A Chaker, A Nahdi… - Biomarkers, 2024
… Idiopathic pulmonary fibrosis (IPF) is the most serious form of interstitial lung disease. We aimed to investigate the effect of Phœnix dactylifera, L. seed oil (DSO) … DSO can play antioxidant and antifibrotic effects on rat models of pulmonary fibrosis …
- Phœnix dactylifera、L.種子油は、ウィスターラットのブレオマイシン誘発性肺線維症と酸化ストレスを軽減
[HTML] Clinical mutations in the TERT and TERC genes coding for telomerase components induced oxidative stress, DNA damage at telomeres and cell apoptosis besides …
B Fernández-Varas, C Manguan-García… - Human Molecular Genetics, 2024
… Mutations in genes coding for proteins involved in telomere protection and elongation produce diseases such as dyskeratosis congenita or idiopathic pulmonary fibrosisknown as telomeropathies. These diseases are characterized by …
Histopathological findings in lung biopsies with usual interstitial pneumonia: Definition of a new classification score for histological fibrotic stages.
M Makovická, A Vrbenská, P Makovický, B Durcová… - General Physiology and …, 2024
… The objective of this article is to describe and classify usual interstitial pneumonia (UIP) changes according to their relevance in the pathology of the idiopathic pulmonary fibrosis(IPF) process. In a cohort of 50 patients (25♀, 25♂) with UIP …
- 通常の間質性肺炎を伴う肺生検における病理組織学的所見: 組織学的線維化段階の新しい分類スコアの定義
[HTML] WSB1, a Hypoxia-Inducible E3 Ligase, Promotes Myofibroblast Accumulation and Attenuates Alveolar Epithelial Regeneration in Mouse Lung Fibrosis
L Chong, L Zou, L Xiang, X Song, W Miao, X Yan, M Xu… - The American Journal of …, 2024
… Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease for which there is … deposition are key pathological features of IPF, eventually leading to cellular hypoxia and … in adult mice ameliorated BLM-induced pulmonary fibrosis …
- 低酸素誘導性 E3 リガーゼである WSB1 はマウス肺線維症における筋線維芽細胞の蓄積を促進し、肺胞上皮再生を弱める
Pathophysiological Metabolic Alteration in Lung Injury and Fibrosis
SR Smith - 2023
… lung damage following severe trauma or in the chronic progression of idiopathic pulmonaryfibrosis (IPF). In the first half of this work, we … of pathogenic lung myofibroblasts in the context of idiopathic pulmonary fibrosis (IPF). IPF is an …
- 肺損傷および線維症における病態生理学的代謝変化
Toll-like Receptor 5 Deficiency Leads to Microbiome-Dependent Lung Injury
R Mindel, Y Sakamachi, F Fouladi, R Invernizzi… - Journal of Allergy and …, 2024
… Microbiome composition was evaluated in induced sputum of lung-healthy smokers and nonsmokers, as well as in bronchoalveolar lavage fluid (BALF) of patients with idiopathicpulmonary fibrosis (IPF) in association with the presence of a …
- Toll-様受容体5欠損はマイクロバイオーム依存性の肺損傷を引き起こす
Research advances in immunosenescence and inflammation in lung diseases
Y Sun, XD Han, XD Liu - Zhonghua jie he he hu xi za zhi= Zhonghua Jiehe he …, 2024
… This review discusses the role of immunosenescence and inflamm-aging in pulmonary diseases such as chronic obstructive pulmonary disease, idiopathic pulmonaryfibrosis, asthma, and lung infections. Understanding the different …
- 肺疾患における免疫老化と炎症に関する研究の進歩
24/02/06
Experimental autotaxin inhibitors for the treatment of idiopathic pulmonary fibrosis
J Simonetti, M Ficili, G Sgalla, L Richeldi - Expert Opinion on Investigational Drugs, 2024
… Idiopathic pulmonary fibrosis (IPF) is the most frequent and severe form of idiopathicinterstitial pneumonia (IIP). IPF is characterized by the … The pathogenesis of IPF involves a complex interplay of cell types and signaling …
- 特発性肺線維症の治療のための実験的autotaxin阻害剤
[PDF] Body mass index and weight loss as risk factors for poor outcomes in patients with idiopathic pulmonary fibrosis: a systematic review and meta-analysis
X He, J Ji, C Liu, Z Luo, J Tang, H Yan, L Guo - Annals of Medicine, 2024
… The association between nutritional status and prognosis of idiopathic pulmonary fibrosis(IPF) remains unclear. This systematic review and meta-analysis aimed to explore the effect of body mass index (BMI) and weight loss on the prognosis of IPF …
Eliglustat exerts anti-fibrotic effects by activating SREBP2 in TGF-β1-treated myofibroblasts derived from patients with idiopathic pulmonary fibrosis
E Kurumiya, M Iwata, Y Kasuya, K Tatsumi, T Honda… - European Journal of …, 2024
… Idiopathic pulmonary fibrosis (IPF) is a progressive chronic lung disease. Myofibroblasts play … signaling may be an effective strategy for IPF treatment. We recently reported that miglustat, … Idiopathic pulmonary fibrosis(IPF) is a …
- Eliglustat は、特発性肺線維症患者由来の TGF-β1 処理筋線維芽細胞内の SREBP2 を活性化することにより抗線維化効果を発揮
Cough Severity Visual Analogue Scale Assesses Cough Burden and Predicts Survival in Idiopathic Pulmonary Fibrosis
Z Wu, DJF Smith, L Yazbeck, P Saunders, JA Smith… - American Journal of …, 2024
… in idiopathic pulmonary fibrosis (IPF) which … IPF its relationship with coughrelated QOL and disease progression remains unexplored (5,6). The aim of this study was to prospectively evaluate the cough VAS at baseline and longitudinally in individuals …
- 咳の重症度視覚的アナログスケールで咳の負担を評価し、特発性肺線維症の生存を予測
[PDF] Manual Therapy as an Alternative Treatment Option for Idiopathic Pulmonary Fibrosis: A Case Report
SS Greenberg, SE Moriarty, I Perera, HE Kasper… - Cureus, 2024
… Idiopathic pulmonary fibrosis (IPF) is a type of interstitial lung disease that results in fibrotic lung tissue leading to symptoms of dyspnea, … of considering manual therapy in patients who have failed the standard of care or are unable to tolerate the …
- 特発性肺線維症の代替治療選択肢としての徒手療法：症例報告
Elucidating shared biomarkers in gastroesophageal reflux disease and idiopathic pulmonary fibrosis: insights into novel therapeutic targets and the role of angelicae …
X Wu, X Xiao, H Fang, C He, H Wang, M Wang, P Lan… - Frontiers in Pharmacology
… GRM8 and ESR1 emerged as potential diagnostic biomarkers for GERD-related IPF, validated in external datasets.This study establishes a causal link between GERD and IPF, identifying five key targets and two potential diagnostic biomarkers …
- 胃食道逆流症と特発性肺線維症における共通のバイオマーカーの解明：新規治療標的と当帰の役割についての洞察
Identification of candidate biomarkers and potential therapeutics for idiopathic pulmonary fibrosis through systems biology approaches
MN Akça - 2023
… Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive disease with an unknown etiology characterised by lung scarring, … molecular signatures and potential drugs for IPF treatment. For this purpose, meta-analysis of transcriptome …
- システム生物学的アプローチによる特発性肺線維症の候補バイオマーカーと潜在的な治療法の同定
Nintedanib and symptoms of fibrotic lung disease: a glimmer of hope for patients living with pulmonary fibrosis
AJ Podolanczuk, KI Aronson - European Respiratory Journal, 2024
… Landmark studies such as ASCEND, CAPACITY and INPULSIS paved the way for approval of the first anti-fibrotic drugs for idiopathic pulmonary fibrosis (IPF) by establishing their ability to slow FVC decline [1–3]. The INBUILD clinical trial …
- ニンテダニブと線維性肺疾患の症状：肺線維症を抱えて生きる患者にとっての希望の光
[HTML] Quantifying Fibrosis in Fibrotic Lung Disease: A Good Human Plus a Machine Is the Best Combination?
AU Wells, SLF Walsh - Annals of the American Thoracic Society, 2024
… in patients with idiopathic pulmonaryfibrosis (IPF) has predicted mortality and decline in PFTs (3, 4). Change in DTA extent in IPF has … (59.6%) and with hypersensitivity pneumonitis, connective tissue disease–related ILD, and non-IPF …
- 特発性肺線維症
[PDF] Do Ultrafine Particles Carry Any Weight when It Comes to Progression of Pulmonary Fibrosis?
MW Frampton - American Journal of Respiratory and Critical Care …, 2024
… Idiopathic pulmonary fibrosis (IPF) is the most common and has the worst prognosis. There is no cure, other than lung transplantation. Consensus clinical guidelines have been published (4, 5), but we know little about the factors …
- 線維性肺疾患における線維化の定量化: 善良な人間と機械の組み合わせは最良か?
24/02/04
A three-gene random forest model for diagnosing idiopathic pulmonary fibrosis based on circadian rhythm-related genes in lung tissue
J He, J Hu, H Liu - Expert Review of Respiratory Medicine, 2024
… Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease of unknown etiology with the same histological and imaging manifestations as common interstitial pneumonia [Citation1,Citation2]. IPF … in the pathogenesis of …
- 肺組織の概日リズム関連遺伝子に基づいて特発性肺線維症を診断するための 3 遺伝子ランダムフォレストモデル
Complications of Fibrotic Interstitial Lung Disease for the General Radiologist
S Watson, G Dixon, A Savill, M Gibbons, S Barrett… - Clinical Radiology, 2024
… Idiopathic pulmonary fibrosis (IPF), the most common of the fibrotic ILDs, is characterised by progressive dyspnoea and cough and is associated with a 3–5year median life expectancy 5. Radiologically, it is characterised by a usual interstitial …
- 一般放射線科医のための線維性間質性肺疾患の合併症
[HTML] Unique Changes in the Lung Microbiome following the Development of Chronic Lung Allograft Dysfunction
Y Yu, YH Kim, WH Cho, D Kim, MW So, BS Son… - Microorganisms, 2024
… The median age of the recipients was 57 years, and most (75%) had undergone lung transplants for idiopathic pulmonary fibrosis. All patients were administered basiliximab for induction therapy and were maintained on three …
- 慢性肺同種移植片機能不全の発症に伴う肺マイクロバイオームの独特な変化
[PDF] Algorithms Identifying Patients With Acute Exacerbation of Interstitial Pneumonia and Acute Interstitial Lung Diseases Developed Using Japanese Administrative Data
K Anan, Y Kataoka, K Ichikado, K Kawamura, Y Yasuda… - Cureus, 2024
… The poor prognosis associated with AE of idiopathic pulmonary fibrosis (IPF; AE-IPF) is well reported. However, AEs of other fibrotic ILDs are also associated with poor prognoses, although little is known about them [2]. Pulmonary alveolar hemorrhage (PAH) …
Stimuli-specific senescence of primary human lung fibroblasts modulates alveolar stem cell function
N Bramey, MC Melo-Narvaez, F See… - 2024
… lung diseases (CLDs) including idiopathicpulmonary fibrosis (IPF) and chronic obstructive … However, whether the senescent phenotype of fibroblasts derived from IPF or COPD … human lung fibroblasts (phLF) from control donors, IPF, or …
- 初代ヒト肺線維芽細胞の刺激特異的老化が肺胞幹細胞の機能を調節
The TIMP Protein Family: Diverse Roles in Pathophysiology
S Coates-Park, J Rich, WG Stetler-Stevenson… - American Journal of …, 2024
… The MMP9/TIMP1 426 imbalance is of special interest not only in pulmonary fibrosis but also other diseases, such as 427 chronic obstructive … TIMP2 expressed by myofibroblasts in idiopathic pulmonary fibrosis 453 is thought to …
- TIMP タンパク質ファミリー: 病態生理学における多様な役割
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特発性肺線維症( idiopathic pulmonary fibrosis (IPF) )関連の学術的情報収集してシェアしています。Google Scholar SearchのUpdateを定期的に掲載しています。GoogleのAIが一定の重み付けはしているとは思いますが、玉石混交です。
当面、毎週アラートの内容をアップしていこうと思います。
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