ChatGPTを活用して業務のAI化を進めています。プロンプトエンジニアリングの専門家です！と、名乗れるレベルではありませんが、かなり色々使いこなしてきています。この１年、病気で失われた能力は、別な能力を発達させる、進化することで生き残っていこうと思います。
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24/02/01
A three-gene random forest model for diagnosing idiopathic pulmonary fibrosis based on circadian rhythm-related genes in lung tissue
J He, J Hu, H Liu - Expert Review of Respiratory Medicine, 2024
… Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease of unknown etiology with the same histological and imaging manifestations as common interstitial pneumonia [Citation1,Citation2]. IPF … in the pathogenesis of …
- 肺組織の概日リズム関連遺伝子に基づいて特発性肺線維症を診断するための 3 遺伝子ランダムフォレストモデル
Complications of Fibrotic Interstitial Lung Disease for the General Radiologist
S Watson, G Dixon, A Savill, M Gibbons, S Barrett… - Clinical Radiology, 2024
… Idiopathic pulmonary fibrosis (IPF), the most common of the fibrotic ILDs, is characterised by progressive dyspnoea and cough and is associated with a 3–5year median life expectancy 5. Radiologically, it is characterised by a usual interstitial …
- 一般放射線科医のための線維性間質性肺疾患の合併症
[HTML] Unique Changes in the Lung Microbiome following the Development of Chronic Lung Allograft Dysfunction
Y Yu, YH Kim, WH Cho, D Kim, MW So, BS Son… - Microorganisms, 2024
… The median age of the recipients was 57 years, and most (75%) had undergone lung transplants for idiopathic pulmonary fibrosis. All patients were administered basiliximab for induction therapy and were maintained on three …
- 慢性肺同種移植片機能不全の発症に伴う肺マイクロバイオームの独特な変化
[PDF] Algorithms Identifying Patients With Acute Exacerbation of Interstitial Pneumonia and Acute Interstitial Lung Diseases Developed Using Japanese Administrative Data
K Anan, Y Kataoka, K Ichikado, K Kawamura, Y Yasuda… - Cureus, 2024
… The poor prognosis associated with AE of idiopathic pulmonary fibrosis (IPF; AE-IPF) is well reported. However, AEs of other fibrotic ILDs are also associated with poor prognoses, although little is known about them [2]. Pulmonary alveolar hemorrhage (PAH) …
Stimuli-specific senescence of primary human lung fibroblasts modulates alveolar stem cell function
N Bramey, MC Melo-Narvaez, F See… - 2024
… lung diseases (CLDs) including idiopathicpulmonary fibrosis (IPF) and chronic obstructive … However, whether the senescent phenotype of fibroblasts derived from IPF or COPD … human lung fibroblasts (phLF) from control donors, IPF, or …
- 初代ヒト肺線維芽細胞の刺激特異的老化が肺胞幹細胞の機能を調節
The TIMP Protein Family: Diverse Roles in Pathophysiology
S Coates-Park, J Rich, WG Stetler-Stevenson… - American Journal of …, 2024
… The MMP9/TIMP1 426 imbalance is of special interest not only in pulmonary fibrosis but also other diseases, such as 427 chronic obstructive … TIMP2 expressed by myofibroblasts in idiopathic pulmonary fibrosis 453 is thought to …
- TIMP タンパク質ファミリー: 病態生理学における多様な役割
24/01/30
[HTML] Antifibrotic Drugs against Idiopathic Pulmonary Fibrosis and Pulmonary Fibrosis Induced by COVID-19: Therapeutic Approaches and Potential Diagnostic Biomarkers
A Perez-Favila, I Garza-Veloz, LS Hernandez-Marquez… - International Journal of …, 2024
… -19 symptoms, such as pulmonary fibrosis, continue to be a concern. This narrative review aims to address pulmonary fibrosis (PF) from various perspectives, including the fibrotic mechanisms involved in idiopathic and COVID-19-induced …
[HTML] Circulating metabolic profile in idiopathic pulmonary fibrosis: data from the IPF-PRO Registry
R Summer, JL Todd, ML Neely, LJ Lobo, A Namen… - Respiratory Research, 2024
… biology, has not been fully characterized in patients with idiopathic pulmonary fibrosis(IPF). We evaluated whether circulating levels of metabolites correlate with the presence of IPF, with the severity of IPF, or with the risk of clinically relevant …
[PDF] Idiopathic Pulmonary Fibrosis: Where do We Stand and How Far to Go?
V Singh, I Ulasov, S Gupta, A Singh, VK Roy… - Discovery Medicine, 2024
… Idiopathic pulmonary fibrosis is a progressive and incurable lung disease characterized by … The clinical presentation of idiopathic pulmonary fibrosis (IPF) involves a gradual and … Idiopathic pulmonary fibrosis(IPF) is a progressive and …
- 特発性肺線維症：我々はどこに立ち、どこまで進むべきなのか？
[HTML] A comprehensive comparison of the safety and efficacy of drugs in the treatment of idiopathic pulmonary fibrosis: a network meta-analysis based on randomized …
X Wu, W Li, Z Luo, Y Chen - BMC Pulmonary Medicine, 2024
… Randomized controlled trials(RCTs) of multiple drugs for Idiopathic pulmonary fibrosis(IPF) have been reported and achieved a certain … them for IPF is not yet well understood. The aim of this network meta-analysis is to assess their safety and …
- 特発性肺線維症の治療における薬剤の安全性と有効性の包括的な比較：ランダム化比較試験に基づくネットワークメタアナリシス
[PDF] Neutrophil extracellular trap formation linked to idiopathic pulmonary fibrosis severity and survival
SM Matson, LT Ngo, Y Sugawara, V Fernando, C Lugo… - medRxiv, 2024
… is associated with worse outcomes in several chronic lung diseases however, there is an unknown role in idiopathic pulmonary fibrosis. … idiopathic pulmonary fibrosis patients and clinical outcomes. Methods: In a discovery cohort of 156 …
- 好中球の細胞外トラップ形成は特発性肺線維症の重症度と生存に関連
[PDF] Leveraging Microbiome Composition Variability for Precision Medicine in Idiopathic Pulmonary Fibrosis
H Fujimoto, CN D'Alessandro-Gabazza, T Yasuma… - American journal of …, 2024
… forward in our understanding of idiopathicpulmonary fibrosis (IPF) and its prognostic factors … depict the pathophysiology and clinical outcomes of IPF (1). Nonetheless, numerous crucial … The lung, gut, and oral microbiomes have been …
- 特発性肺線維症における精密医療のためのマイクロバイオーム構成の多様性の活用
The Gene Expression of CALD1, CDH2, and POSTN in fibroblast are related to Idiopathic Pulmonary Fibrosis
W Shu-Fei, M Liu, M Zhang, X Ye, H Gu, C Jiang, H Zhu… - Frontiers in Immunology
… Idiopathic pulmonary fibrosis is a progressive lung disorder characterized by excessive collagen production and tissue scarring. However, the molecular mechanisms underlying pulmonary fibrosis are still … Gene expression analysis of …
- 線維芽細胞におけるCALD1、CDH2、およびPOSTNの遺伝子発現は、特発性肺線維症に関連
[PDF] Environmental Exposure-Induced Exacerbation of Idiopathic Pulmonary Fibrosis
SP Devkota, S Hussain
… induces more inflammation and tissue remodeling indicating its role in IPF exacerbation. … Clinical and economic burden of idiopathicpulmonary fibrosis: a retrospective cohort study. … Global incidence and prevalence of idiopathic …
- 環境曝露による特発性肺線維症の増悪
Risk of Potential Hepatotoxicity from Pirfenidone or Nintedanib in Patients with Idiopathic Pulmonary Fibrosis: Results of a Retrospective Analysis of a Large Insurance …
KM Liao, CY Chen - Frontiers in Pharmacology
… A growing population of individuals diagnosed with idiopathic pulmonary fibrosis (IPF) are receiving treatment with nintedanib and … pirfenidone and nintedanib in patients with IPF in Taiwan.We collected a cohort of adult patients diagnosed with …
- 特発性肺線維症患者におけるピルフェニドンまたはニンテダニブによる潜在的な肝毒性のリスク：台湾の大規模保険データベースの遡及的分析の結果
[HTML] Lung Transplantation in Patients with Previous or Unknown Oncological Disease: Evaluation of Short-and Long-Term Outcomes
C Catelli, E Faccioli, S Silvestrin, G Lorenzoni, L Luzzi… - Cancers, 2024
… Additionally, in lung disease such as idiopathic pulmonary fibrosis (IPF) and sarcoidosis, the inflammatory stimulus can lead to an increased risk of undiagnosed neoplasia before LTX. Often, radiological images of patients with end-stage lung …
- 既往または不明の腫瘍疾患患者における肺移植: 短期および長期の転帰の評価
24/01/28
[HTML] Inhibitor of PD-1/PD-L1: a new approach may be beneficial for the treatment of idiopathic pulmonary fibrosis
J Tan, Q Xue, X Hu, J Yang - Journal of Translational Medicine, 2024
… interstitial pneumonia and lung cancer, suggesting that some immune checkpoints in IPFare similar to those in tumors. Immune checkpoints are a … IPF treatment. This review discusses the application of PD-1/PD-L1 checkpoint in IPF …
- PD-1/PD-L1 阻害剤: 新しいアプローチは特発性肺線維症の治療に有益である可能性
[HTML] Assessment of lung deformation in patients with idiopathic pulmonary fibrosis with elastic registration technique on pulmonary three-dimensional ultrashort echo time …
X Yang, P Yu, H Sun, M Deng, A Liu, C Li, W Meng… - Insights into Imaging, 2024
… idiopathic pulmonary fibrosis (IPF) patients and correlated with the severity of IPF. Elastic registration of inspiratory-to-expiratory three-dimensional … echo time (3D UTE) MRI may be a new morphological and functional marker for non-radiation and …
A microdroplet SERS-RCA biosensor with enhanced specificity and reproducibility for profiling dual miRNAs in idiopathic pulmonary fibrosis diagnosis and monitoring
J Qian, L Zhao, Y Huang, C Zhao, H Liu, X Liu… - Chemical Engineering …, 2024
… for the precise diagnosis and monitoring of idiopathic pulmonary fibrosis (IPF). In this study, … -21 and miRNA-155 in the serum of IPFpatients. By utilizing the RCA strategy, the constructed … can serve as an auxiliary diagnostic tool for IPF risk …
- 特発性肺線維症の診断およびモニタリングにおけるデュアル miRNA のプロファイリングのための特異性と再現性が強化された微液滴 SERS-RCA バイオセンサー
[HTML] circGRHPR inhibits aberrant epithelial-mesenchymal transformation progression of lung epithelial cells associated with idiopathic pulmonary fibrosis
W Wu, Z Wang, H Zhang, X Zhang, H Tian - Cell Biology and Toxicology, 2024
… Air pollution has greatly increased the risk of idiopathic pulmonary fibrosis (IPF). Circular RNAs (circRNAs) have been found to play a significant role in the advancement of IPF, but there is limited evidence of correlation between circRNAs …
- circGRHPRは、特発性肺線維症に関連する肺上皮細胞の異常な上皮間葉形質転換の進行を阻害
[PDF] Unveiling the Diagnostic Potential: A Comprehensive Review of Bronchoalveolar Lavage in Interstitial Lung Disease
A Sindhu, U Jadhav, B Ghewade, P Wagh, P Yadav… - Cureus, 2024
… ILD refers to a group of diffuse parenchymal lung disorders, encompassing a spectrum of conditions such as idiopathic pulmonaryfibrosis (IPF), sarcoidosis, and connective tissue disease-associated ILD (CTD-ILD). Characterized by inflammation …
- 診断の可能性を明らかにする: 間質性肺疾患における気管支肺胞洗浄の包括的なレビュー
[HTML] Adenophorae Radix Reduces Fibrosis in a Bleomycin-Induced Pulmonary Fibrosis Mouse Model
EJ Kim, J Park, CH Yu, JW Park, KI Kim, HJ Jung… - Natural Product …, 2024
… pulmonary fibrosis in an animal model of idiopathic pulmonary fibrosis; thus, ADR can be considered as a candidate treatment for lung fibrosis. … Efficacy and safety of nintedanib for the treatment of idiopathic pulmonary fibrosis: an update. Drugs R D …
- アデノフォラ基はブレオマイシン誘発性肺線維症マウスモデルの線維症を軽減
[PDF] Tetrahedral framework nucleic acids loaded siCCR2 restrains M1 macrophage polarization to ameliorate pulmonary fibrosis in chemoradiation-induced murine model
C Li, X Feng, S Li, X He, Z Luo, X Cheng, J Yao, J Xiao… - Molecular Therapy, 2024
… As one of the most commonly respiratory diseases with devastating prognosis, idiopathic52 pulmonary fibrosis (IPF) mainly leads to alveolar dysfunction and lung failure.Up to 50% of 53 IPF patients dying within 3 years in the absence of …
[HTML] The association between adipokines and pulmonary diseases: a mendelian randomization study
D Wu, Z Wang, K Wang, Y Wang, T Wang - BMC Pulmonary Medicine, 2024
… and the likelihood of interstitial lung disease, including idiopathic pulmonary fibrosis. … idiopathic pulmonary fibrosis remains a subject of ongoing debate. The current study clarifies a negative association between adiponectin levels and the …
- アディポカインと肺疾患との関連性: メンデルランダム化研究
[PDF] SOX9-regulated matrix proteins predict poor outcomes in patients with COVID-19 and pulmonary fibrosis
L Pearmain, E Jokl, K Simpson, L Birchall, Y Ou… - bioRxiv, 2024
… To underscore the translational potential of our SOX9-regulated markers, we analysed serum samples from acute COVID19, post COVID19 and idiopathic pulmonary fibrosis (IPF) patient cohorts. Our hypothesis driven SOX9-panels …
[PDF] Potential Rheumatoid Arthritis-Associated Interstitial Lung Disease Treatment and Computational Approach for Future Drug Development
EJ Jeong, H Hong, KS Kim - 2024
… Currently, the first-line treatment for RA-ILD primarily relies on drugs used for idiopathicpulmonary fibrosis (IPF) because the two diseases share similar clinical, radiological, and molecular patterns. Two major drugs, pirfenidone and nintedanib …
- 関節リウマチに関連する間質性肺疾患の治療と将来の医薬品開発のための計算アプローチの可能性
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特発性肺線維症( idiopathic pulmonary fibrosis (IPF) )関連の学術的情報収集してシェアしています。Google Scholar SearchのUpdateを定期的に掲載しています。GoogleのAIが一定の重み付けはしているとは思いますが、玉石混交です。
当面、毎週アラートの内容をアップしていこうと思います。
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