ChatGPTを活用して業務のAI化を進めています。プロンプトエンジニアリングの専門家です！と、名乗れるレベルではありませんが、かなり色々使いこなしてきています。この１年、病気で失われた能力は、別な能力を発達させる、進化することで生き残っていこうと思います。
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24/08/16
siTGF-β1 and pirfenidone contained Ionizable-Liposomal nanodrug for enhanced treatment of Idiopathic pulmonary fibrosis
C Yu, Q Xu, X Cao, S Cheng, Z Zhang, J Huang - Chemical Engineering Journal, 2024
… Idiopathic pulmonary fibrosis (IPF) is a challenging interstitial lung disease characterized by heterogeneous manifestations and significant mortality. Due to the relative complexity of IPF … -β1 in IPF, we first analyzed the published scRNA-seq …
- 特発性肺線維症の治療を強化するためのsiTGF-β1とピルフェニドンを含むイオン化リポソームナノドラッグ
[PDF] Elevated Suicide Risk in Idiopathic Pulmonary Fibrosis Patients
JT Yu, CP Li, HC Chang, SY Gau - American Journal of Respiratory and Critical Care …, 2024
… of IPF and suicide risk. For example, antifibrotic treatments decrease mortality as well as acute exacerbations in IPF patients, which might alleviate some psychological distress due to the prognosis of IPF (… in patients with idiopathic …
- 特発性肺線維症患者の自殺リスクの上昇
[PDF] Transitional alveolar epithelial cells and microenvironmental stiffness synergistically drive fibroblast activation in three-dimensional hydrogel lung models
CM Magin
… Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease that progressively and irreversibly alters the lung parenchyma, eventually … weeks and displayed differentiation patterns observed in vivo during IPFprogression …
- 移行性肺胞上皮細胞と微小環境の硬さは、三次元ハイドロゲル肺モデルにおいて相乗的に線維芽細胞の活性化を促進する
Identification of key mitochondria-related genes and their potential crosstalk role with immune pattern in Idiopathic pulmonary fibrosis
J Huang, X Wang, Y Zeng, H Xu, S Zhang, Z Ding… - Gene, 2024
… associated with mitochondria in idiopathicpulmonary fibrosis (IPF). Through comprehensive analysis of gene expression profiles in IPF patients and normal controls, our goal is to elucidate the pivotal role played by these genes in the …
[HTML] Early pirfenidone treatment enhances lung function in idiopathic pulmonary fibrosis patients
JW Zhang - World Journal of Clinical Cases, 2024
… This study evaluates the efficacy of early treatment with pirfenidone on lung function in patients with IPF. The early and advanced stages of IPF are defined, highlighting the drug's benefits. While prior research indicates pirfenidone's …
- 早期ピルフェニドン治療は特発性肺線維症患者の肺機能を改善する
[PDF] Extent of Alveolar Collapse in Expiratory CT as a Prognostic Marker in Idiopathic Pulmonary Fibrosis
SC Scharm, C Schaefer-Prokop, A Schreuder, J Ehmig… - 2024
… on inspiration and expiration can indicate alveolar collapse and predict progression in patients with idiopathic pulmonary fibrosis(IPF). … In this retrospective study, CT scans of IPF patients imaged in the inspiratory and expiratory …
- 特発性肺線維症の予後マーカーとしての呼気CTにおける肺胞虚脱の程度
[HTML] Emerging role of BMPs/BMPR2 signaling pathway in treatment for pulmonary fibrosis
Q Ye, SJ Taleb, J Zhao, Y Zhao - Biomedicine & Pharmacotherapy, 2024
… Pulmonary fibrosis is a fatal and chronic lung disease that is characterized by accumulation of thickened scar in the lungs and … idiopathic pulmonary fibrosis (IPF). There are currently no effective therapeutics to cure the disease; thus, the …
- 肺線維症の治療における BMP/BMPR2 シグナル伝達経路の新たな役割
[PDF] The Hidden Link Between Chronic Kidney Disease and Lung Injury
EF Redente - American Journal of Respiratory Cell and Molecular …, 2024
… Clinical studies in CKD patients have increasingly reported higher incidences of restrictive lung diseases including idiopathicpulmonary fibrosis (IPF) (5, 6) indicating a need for further investigation into the kidney-lung axis. Here …
- 慢性腎臓病と肺損傷の隠れたつながり
Preparation, Characterization and Evaluation of Nintedanib Amorphous Solid Dispersions with Enhanced Oral Bioavailability
S Liu, H Chen, F Zhou, S Tiwari, K Zhuang, Y Shan… - AAPS PharmSciTech, 2024
… Nintedanib (NDNB) is a typical BCS class II drug that has been utilized to treat idiopathicpulmonary fibrosis (IPF). Due to the low solubility, its oral bioavailability is relatively low, limiting its therapeutical effectiveness. It is crucial to enhance the …
- 経口バイオアベイラビリティーを高めたニンテダニブ非晶質固体分散体の調製、特性評価
24/08/14
Effects of home-based telerehabilitation-assisted inspiratory muscle training in patients with idiopathic pulmonary fibrosis: A randomized controlled trial
R Aktan, KC Tertemiz, S Yiğit, S Özalevli, AO Alpaydin… - Respirology (Carlton, Vic.)
… IMT) as an intervention for patients with isolated idiopathic pulmonary fibrosis (IPF). This study aimed to investigate and interpret the effects of home-based telerehabilitation-assisted IMT in patients with IPF. Methods: Twenty-eight …
24/08/12
[HTML] Causal relationship between serum metabolites and idiopathic pulmonary fibrosis: insights from a two-sample Mendelian randomization study
QC Zou, JP Hu, Y Cao, C She, LH Liang, ZY Liu - Heliyon, 2024
… Idiopathic pulmonary fibrosis (IPF) is an irreversible lung disease with unclear pathological mechanisms. In this study, we utilized bidirectional Mendelian randomization (MR) to analyze the relationship between serum metabolites and IPF …
- 血清代謝物と特発性肺線維症の因果関係：2サンプルメンデルランダム化研究からの知見
[HTML] Optimized inhaled LNP formulation for enhanced treatment of idiopathic pulmonary fibrosis via mRNA-mediated antibody therapy
X Bai, Q Chen, F Li, Y Teng, M Tang, J Huang, X Xu… - Nature Communications, 2024
… with potential for treating various respiratory diseases, including idiopathic pulmonaryfibrosis. … forms is idiopathic pulmonaryfibrosis (IPF), a fibrotic-predominant ILD distinguished by extensive fibrotic lesions and a higher mortality rate than many …
- mRNA を介した抗体療法による特発性肺線維症の治療を強化するために最適化された吸入 LNP 製剤
Association between diabetes mellitus and lower respiratory tract and pulmonary diseases: scientific discussion
SL Babak, MV Gorbunova, EE Gubernatorova… - Therapy, 2024
… Current review summarizes ideas about the role of diabetes in the formation of pulmonary tissue pathology, especially in cases of idiopathic pulmonary fibrosis development in diabetes mellitus patients – a progressive disease with high …
- 糖尿病と下気道および肺疾患との関連性：科学的議論
Integrated Multiscale Mechano-Biological Study of Lung and Liver Tissues
H Xiao - 2024
… -β), a key factor in the progression of IPF, can induce lung fibroblast spheroids to produce tissue-… fibrotic diseases, advanced stages of idiopathic pulmonary fibrosis (IPF) and several other lung … We apply our system to idiopathic pulmonary …
- 肺と肝臓組織の統合マルチスケール機械生物学的研究
24/08/11
[PDF] SPP1 promotes the polarization of M2 macrophages through the Jak2/Stat3 signaling pathway and accelerates the progression of idiopathic pulmonary fibrosis
X Yang, Z Liu, J Zhou, J Guo, T Han, Y Liu, Y Li, Y Bai… - International Journal of …, 2024
… Idiopathic pulmonary fibrosis (IPF) is a fatal pulmo‑ nary disease that requires further … expressed in the lung tissue of patients with IPFand was significantly positively associated with … enhanced lung function and ameliorated pulmonary …
- SPP1はJak2/Stat3シグナル伝達経路を介してM2マクロファージの分極を促進し、特発性肺線維症の進行を加速する
The impact of psoriasis on idiopathic pulmonary fibrosis: a two‐sample Mendelian randomization study
Q Wang, Y Wu, S Jia, M Zhao - International Journal of Dermatology, 2024
… study is to investigate whether psoriasis could independently increase the risk of idiopathicpulmonary fibrosis (IPF). … Idiopathicpulmonary fibrosis (IPF) is a fatal disease characterized by progressive lung fibrosis with an unknown etiology.A case …
- 乾癬が特発性肺線維症に与える影響：2サンプルメンデルランダム化研究
YAP Alleviates Pulmonary Fibrosis through Promoting Alveolar Regeneration via Modulating the Stemness of Alveolar Type 2 Cells
J Wang, F Zhu, R Luo, Y Cui, Z Zhang, M Xu, Y Zhao… - Stem Cells and …, 2024
… Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with no cure except transplantation. Abnormal alveolar epithelial … in alveolar regeneration and IPF pathogenesis. Our findings provide new insights to the regulation of alveolar …
- YAP は肺胞 2 型細胞の幹細胞性を調節して肺胞再生を促進し、肺線維症を軽減します。
[PDF] Spatial transcriptomic characterization of pathologic niches in IPF
CH Mayr, D Santacruz, S Jarosch, M Bleck, J Dalton… - Science Advances, 2024
… These scRNA- seq studies have identified previously unknown fibrosis- specific cell types and molecular changes associated with idiopathic pulmonary fibrosis (IPF), laying the foundation for a new understanding of fundamental biological processes …
- IPF における病理学的ニッチの空間的トランスクリプトーム特性
24/08/10
[HTML] Key learnings from the INBUILD trial in patients with progressive pulmonary fibrosis
I Mira-Avendano, M Kaye - Therapeutic Advances in Respiratory Disease, 2024
… In a patient with interstitial lung disease (ILD) of known or unknown etiology other than idiopathic pulmonary fibrosis (IPF), progressive pulmonary fibrosis (PPF) is defined by worsening lung fibrosis on high-resolution computed tomography (HRCT) …
- 進行性肺線維症患者を対象としたINBUILD試験から得られた重要な知見
[PDF] CD27/CD70 and idiopathic pulmonary fibrosis
Y XU, J ZHENG - Basic & Clinical Medicine, 2024
… Abstract:Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease marked by the significant in⁃ volvement of fibroblasts,… Consequently, the CD27/CD70 axis presents a promising new target for immunotherapy in IPF. Key words:idiopathic …
- CD27/CD70と特発性肺線維症
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特発性肺線維症( idiopathic pulmonary fibrosis (IPF) )関連の学術的情報収集してシェアしています。Google Scholar SearchのUpdateを定期的に掲載しています。GoogleのAIが一定の重み付けはしているとは思いますが、玉石混交です。
当面、毎週アラートの内容をアップしていこうと思います。
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