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24/11/09
[PDF] Prevalence, Clinical Features, and Outcomes of Young Patients with Idiopathic Pulmonary Fibrosis
J Lee, KJ Kim, JH Nam, JY Choi, CK Rhee, YS Jo - Respiration
… This study examined the clinical features and outcomes of younger patients with idiopathicpulmonary fibrosis (IPF). Results showed that young patients with IPF exhibit lower risks of mortality and lung transplantation but are more often treated …
- 特発性肺線維症の若年患者の有病率、臨床的特徴、転帰
Idiopathic Pulmonary Fibrosis: Delineating the Impact of Comorbidities and Therapeutics on Prognosis Using Electronic Health Record Data
B Ozaltin - 2024
… Two different retrospective case-control studies were conducted to observe the impact of risk factors on IPF survival. The first was a study … with IPF. We wanted to determine whether patients with IPF should be considered to have a largely single-system …
- 特発性肺線維症：電子健康記録データを用いた合併症と治療薬の予後への影響の解明
Yohimbine treatment improves pulmonary fibrosis by attenuating the inflammation and oxidative stress via modulating the MAPK pathway
V Kambhampati, A Eedara, SB Andugulapati - Biochemical Pharmacology, 2024
… Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disorder characterized by the accumulation of extracellular matrix and … in BEAS-2B/LL29 cells and bleomycin (BLMN) induced pulmonaryfibrosis model in rats. Network …
- ヨヒンビン治療はMAPK経路を調節することで炎症と酸化ストレスを軽減し、肺線維症を改善する。
Beneficial Impact of Vaccination Against SARS-CoV-2 on the Mental Health of IPF Patients
I Tomos, AI Papaioannou, ZI Daniil, IE Dimeas… - Advances in Respiratory …, 2024
… Background: Depression and anxiety represent significant comorbidities in idiopathicpulmonary fibrosis (IPF) patients, affecting their … of COVID-19 vaccination on depression and anxiety in IPF patients. Methods: Consecutive IPF …
[HTML] Molecular imaging in experimental pulmonary fibrosis reveals that nintedanib unexpectedly modulates CCR2 immune cell infiltration
H Farooq, HP Luehmann, JR Koenitzer, GS Heo… - eBioMedicine, 2024
… We and others have reported that CCR2+ cells are elevated even in the lungs of patients with end-stage idiopathic pulmonary fibrosis(IPF) and enriched in the peri-fibrotic zones of the lungs. In the fibrotic lung, CCR2+ interstitial macrophages produce TGF-β …
- 実験的肺線維症における分子イメージングにより、ニンテダニブがCCR2免疫細胞浸潤を予想外に調節することが明らかになった
Post-hoc biomarker analysis in participants with IPF receiving bexotegrast over 12-weeks in INTEGRIS-IPF
M Decaris, R Ahn, C Barnes, E Lefebvre, G Cosgrove… - 2024
… idiopathic pulmonary fibrosis (IPF). Here we used proteomic screening to assess longitudinal changes in plasma protein levels in participants with IPF … with IPF over 12 weeks (Wuyts, W. et al. ERS Int Conf 2023, #42463), to identify candidate …
- INTEGRIS-IPFで12週間にわたりベキソテグラストを投与されたIPF患者の事後バイオマーカー解析
24/11/08
Hypnotics and Mortality in Idiopathic Pulmonary Fibrosis: Hospital and National Data-based Analysis
H Hozumi, Y Endo, M Kono, H Hasegawa, K Miyashita… - CHEST, 2024
… Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease characterized by 32 high mortality 1-6. IPF patients may suffer not only from respiratory symptoms, but also from 33 the psychological burden caused by these …
- 特発性肺線維症における睡眠薬と死亡率：病院および国のデータに基づく分析
[HTML] Patients with idiopathic pulmonary fibrosis have fatty lungs impacting respiratory physiology
W Lu, AM Shahzad, J Larby, M Waters, M Wilson… - Pulmonology, 2025
… Idiopathic pulmonary fibrosis (IPF) is a chronically progressive and irreversible fibrosing disease with an unknown cause. The development of IPF is … Citation2 Here, we report novel findings of adipose tissue deposition in the lungs of patients …
- 特発性肺線維症の患者は肺に脂肪が蓄積し、呼吸生理機能に影響を及ぼしている。
[HTML] Cell Membrane Hybrid Liposome-Targeted Delivery of the Heat Shock Protein 90 C-Terminal Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis
J Yang, D Lu, Y Sun, M Qiu, T Zhao, B Yan, S Wang… - ACS Pharmacology & …, 2024
… Idiopathic pulmonary fibrosis (IPF) represents a grave challenge as it is characterized by … -β1 (TGF-β1), which could potentially ameliorate IPF symptoms. However, given that the broad … To facilitate targeted therapy for treating IPF, a cell …
- 特発性肺線維症の治療のための熱ショックタンパク質 90 C 末端阻害剤の細胞膜ハイブリッドリポソーム標的送達
[HTML] Clinical Characteristics and Outcomes of Interstitial Lung Disease Patients with Acute Respiratory Failure Admitted to the ICU
S Pahuja, M Kuriakose, S Agarwal, P Bajad, A Khanna… - Amrita Journal of Medicine, 2024
… The mean hospital stay time was considerably higher in patients with idiopathic pulmonaryfibrosis (IPF) and in patients with Type 2 … Outcome of patients with idiopathic pulmonaryfibrosis admitted to the intensive care unit. Am J Respir Crit …
Immunological profile of lung tissue of patients with hypersensitivity pneumonitis
MM Gómez, SS Díez, DS Segovia, SG Ollés… - 2024
… pulmonary fibrosis in patients with advanced HP. Methods: Cross-sectional study conducted in 19 patients diagnosed with fibrotic HP and 10 patients diagnosed with idiopathic pulmonaryfibrosis (IPF… Results: Fibrotic HP and IPFpatients had higher …
- 過敏性肺炎患者の肺組織の免疫学的プロファイル
[HTML] Comorbidity in Venous Thromboembolic Disease
JJJ Esteban, LAF Bermejo, JDM Díez, MÁM Lucas… - 2024
… (COPD), asthma, heart failure (HF), or idiopathic pulmonary fibrosis (IPF), comorbidities are frequent and increase with age and disease progression. … have appeared with representation of comorbidities and comorbidome in patients with …
- 静脈血栓塞栓症における合併症
Increased monocyte count as a prognostic biomarker in patients with interstitial lung disease with autoimmune features
P Tsiri, V Sotiropoulou, M Katsaras, O Papaioannou… - 2024
… Given its prognostic value in patients with Idiopathic Pulmonary Fibrosis, peripheral blood monocyte count may have a prognostic role in … =14, 11%) with scleroderma, twenty-eight (n=28, 21%) with idiopathic inflammatory myopathies …
- 自己免疫性特徴を伴う間質性肺疾患患者の予後バイオマーカーとしての単球数の増加
Early Process Development of an LPAR1 Antagonist, GS-2278
N Kadunce, AM Wagner, J Cottell, K Dao, DD Dixon… - Organic Process Research …, 2024
… acid receptor 1 antagonist under development for the treatment of idiopathic pulmonaryfibrosis. GS-2278 is assembled in a 9-step sequence. … Idiopathic pulmonary fibrosis(IPF) is a chronic and progressive fibrotic lung condition of …
- LPAR1拮抗薬GS-2278の初期プロセス開発
24/11/07
Real-world data on the course of idiopathic pulmonary fibrosis
SD Nathan, JS Lee - The American journal of managed care, 2024
… Idiopathic pulmonary fibrosis (IPF) is characterized by a progressive decline in lung function, worsening quality of life, and high mortality. However, the rate and pattern of progression of IPF … important information on the clinical course of IPF …
- 特発性肺線維症の経過に関する実世界データ
S157 Exploring the function of PKN2 in idiopathic pulmonary fibrosis
CE McMullan, P Rajasekar, AJ Hall, P Stylianou… - 2024
Background and Aims Idiopathic pulmonaryfibrosis (IPF) is a chronic interstitial lung disease with unknown aetiology. Variant rs115982800 was identified in a GWAS of decline in forced vital capacity in individuals with IPF. PKN2 was identified as the …
- 特発性肺線維症におけるPKN2の機能の探究
[HTML] … Insights into the biological mechanisms of signals from a genome-wide association study of susceptibility to idiopathic pulmonary fibrosis using alternative genetic …
T Hernandez-Beeftink, D Chin, L Donoghue… - 2024
… Introduction Idiopathic pulmonary fibrosis(IPF) is a rare progressive lung disease with limited treatment options and poor prognosis. … Our previous GWAS comprising 5,159 IPF cases and 27,459 controls from seven independent studies …
- 代替遺伝子モデルを用いた特発性肺線維症感受性のゲノムワイド関連研究から得られたシグナルの生物学的メカニズムに関する洞察
P63 Assessment of the idiopathic pulmonary fibrosis patient reported outcome measure (IPF-PROM) scale in idiopathic pulmonary fibrosis patients in relation to …
M Tziraki, KM Antoniou, M Linardakis, A Zouraraki… - 2024
… Introduction and Objectives Idiopathicpulmonary fibrosis (IPF) is a progressive debilitating lung disease, … IdiopathicPulmonary Fibrosis Patient Reported Outcome Measure (IPF-PROM) scale as a clinical tool to interrelate depression …
- 特発性肺線維症患者におけるうつ病症状と生活の質との関連における特発性肺線維症患者報告アウトカム尺度（IPF-PROM）の評価
P145 Characterising antifibrotic treatment patterns in patients with idiopathic pulmonary fibrosis in the US: a retrospective cohort study
MCP Ramos, AA Londhe, P Pimple, S Langham… - 2024
… in idiopathic pulmonary fibrosis (IPF). There are limited data on real-world antifibrotic treatment patterns in patients with IPF in the US. … between 1/10/2014 and 31/12/2021 and continuous enrolment for 1 year prior and 1 year after first IPF …
- 米国における特発性肺線維症患者に対する抗線維化治療パターンの特徴づけ：後ろ向きコホート研究
S151 Investigating the interaction between Hemicentin-1 and TGF-beta in idiopathic pulmonary fibrosis
H Yao, H Ding, B Liu, E Lopez, D Wang, G Jenkins… - 2024
… Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease for which there is currently no cure. A key characteristic of IPF is … variants in hemicentin-1 (HMCN1) in IPF, upregulated HMCN1 gene expression in IPFtissues …
- 特発性肺線維症におけるヘミセンチン-1とTGF-βの相互作用の調査
S152 Extracellular vesicles mediate macrophage functional impairment in idiopathic pulmonary fibrosis
C Mafham, KL Spencer, E Jenkins, LE Crowley… - 2024
… of idiopathic pulmonary fibrosis (IPF), however specific mechanisms have not been elucidated. We sought to characterise plasma EVs from IPF patients and investigate their effect on macrophage effector functions. We isolated EVs from the …
- 特発性肺線維症におけるマクロファージの機能障害は細胞外小胞によって媒介される
S154 The impact of the IPF-associated variant rs62025270 on AKAP13-mediated signalling and epithelial cell dysfunction in idiopathic pulmonary fibrosis
B Liu, SY Wang, E Pyman, A Vairon, M Zarcone… - 2024
Background and Aims The variant rs62025270 (G>A) near the A-kinase anchoring protein 13 (AKAP13) gene has been associated with an increased risk of idiopathic pulmonary fibrosis(IPF). The A allele of this polymorphism is linked to elevated …
- IPF関連変異rs62025270が特発性肺線維症におけるAKAP13を介したシグナル伝達と上皮細胞機能障害に与える影響
[PDF] … of the Lung for Carbon Monoxide (DLCO) Ratio Increases Clinical Suspicion for Fibrotic Hypersensitivity Pneumonitis (FHP) Over Idiopathic Pulmonary Fibrosis (IPF)
TS Vongvivitpatana, AM Nambiar - Cureus, 2024
Methods A retrospective chart review was performed at a single academic ILD center. Patients with a probable or definite diagnosis of FHP or IPF were considered for inclusion, while patients with poor-quality pulmonary function tests (PFTs) were …
- 努力肺活量 (FVC) / 一酸化炭素肺拡散能 (DLCO) 比が低い場合、特発性肺線維症 (IPF) よりも線維性過敏性肺炎 (FHP) の臨床的疑いが高まります。
S68 The effect of hydrogen sulfide supplementation on the pro-fibrotic profile of monocytes in idiopathic pulmonary fibrosis
E Leonova, X Dun, SL Barratt, MA Lindsay… - 2024
… Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease with limited therapeutic treatments. Aberrant wound healing is a key pathophysiological mechanism. Peripheral blood monocyte count is a prognostic marker in IPF; …
- 特発性肺線維症における単球の線維化促進プロファイルに対する硫化水素補給の効果
24/11/06
Pharmacological Treatment of Idiopathic Pulmonary Fibrosis (Update) and Progressive Pulmonary Fibroses: S2k Guideline of the German Respiratory Society
JBFBB Christian, FA Güntherd, LHJHP Klemmg… - 2024
… the acute (inflammatory) type of extrinsic allergic alveolitis may resolve without sequelae (restitutio ad integrum), idiopathic pulmonaryfibrosis (IPF) is the prototypic fibrotic ILD with a progressive course, leading to irreversible and progressive fibrosis …
- 特発性肺線維症（最新版）および進行性肺線維症の薬物治療：ドイツ呼吸器学会の S2k ガイドライン
24/11/05
[HTML] Spatially resolved gene expression profiles of fibrosing interstitial lung diseases
SJ Kim, MJ Cecchini, E Woo, N Jayawardena… - Scientific Reports, 2024
… Previous gene expression profiling studies focused on idiopathic pulmonary fibrosis (IPF) and bulk tissue samples. We employed digital spatial profiling to gain new insights into the spatial resolution of gene expression across distinct lung …
- 線維性間質性肺疾患の空間的に分解された遺伝子発現プロファイル
[PDF] Early View
RG Jenkins, V Cottin, Y Nishioka, I Noth, ES White… - 2024
… Effects of nintedanib on circulating biomarkers of idiopathic pulmonary fibrosis. ERJ Open Res 2024; in press (https://doi.org/10.1183/… Background: Biomarkers that change in response to nintedanib in subjects with idiopathic pulmonary fibrosis (IPF) …
- 早期の見解
24/11/03
miRNA expression profiling of lung endothelial cells reveals elevated miR-205-5p in aged mice with persistent lung fibrosis and in IPF-derived endothelial cells
G Muscato, BB Roos, F Gianì, PA Link, AA Raslan… - 2024
… tissue remodeling in aging and IdiopathicPulmonary Fibrosis (IPF). Using mouse models of lung … from healthy and IPF lungs showed increased expression of miR-205-5p in IPFLECs, … genes are important regulators of endothelial function known to be …
- 肺内皮細胞の miRNA 発現プロファイリングにより、持続性肺線維症の老齢マウスおよび IPF 由来の内皮細胞で miR-205-5p が上昇していることが明らかになりました。
Study on diffuse cystic lung disease based on deep learning.
X Jia, C Qiantong, LU Yingxin, Z Sijie, H Junjie… - Journal of Practical …, 2024
… Methods A total of 288 patients diagnosed with idiopathic pulmonary fibrosis(IPF),pulmonary lymphangioleiomyomatosis (PLAM),and pulmonary Langerhans cell histiocytosis (PLCH)were prospectively enrolled from the First Affiliated Hospital of Guangzhou Medical …
- ディープラーニングに基づくびまん性嚢胞性肺疾患の研究。
24/11/02
[PDF] Gene polymorphisms and risk of idiopathic pulmonary fibrosis: a systematic review and meta-analysis
M Hassan, AS Ali, ABS Zubairi, ZA Padhani, S Kirmani… - Monaldi Archives for Chest …, 2024
Idiopathic pulmonary fibrosis (IPF) has been widely hypothesized to occur as a result of an interplay between a nexus of environmental and genetic risk factors. However, not much is known about the genetic aspect of this disease. The objective …
- 遺伝子多型と特発性肺線維症のリスク：系統的レビューとメタ分析
COVID-19 in patients with interstitial lung disease
E Vasarmidi, P Le Guen, T Goletto, B Crestani - COVID-19: An Update (ERS …, 2024
… Idiopathic pulmonary fibrosis (IPF) is widely considered the prototype of fibrotic ILDs, it lacks a precise causative factor and is characterised by a progressive phenotype and poor prognosis [3]. Patients with ILDs tend to be older and have …
- 間質性肺疾患患者におけるCOVID-19
The patient perspective of the pandemic
C Williams - COVID-19: An Update (ERS Monograph). Sheffield …, 2024
… (Patient with idiopathic pulmonary fibrosis)[9] " I like to pretend that we're not in COVID. So, on a Friday night, I'll get all dressed up, I'll do my makeup, I'll do my hair and then again, I'll just sit on my bed and watch Netflix.”(Lung transplant recipient)[23] …
- パンデミックに対する患者の視点
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特発性肺線維症( idiopathic pulmonary fibrosis (IPF) )関連の学術的情報収集してシェアしています。Google Scholar SearchのUpdateを定期的に掲載しています。GoogleのAIが一定の重み付けはしているとは思いますが、玉石混交です。
当面、毎週アラートの内容をアップしていこうと思います。
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