ChatGPTを活用して業務のAI化を進めています。プロンプトエンジニアリングの専門家です！と、名乗れるレベルではありませんが、かなり色々使いこなしてきています。この１年、病気で失われた能力は、別な能力を発達させる、進化することで生き残っていこうと思います。
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24/02/17
[HTML] Different Levels of Autophagy Activity in Mesenchymal Stem Cells Are Involved in the Progression of Idiopathic Pulmonary Fibrosis
H Tao, Q Lv, J Zhang, L Chen, Y Yang, W Sun - Stem Cells International, 2024
… Idiopathic pulmonary fibrosis (IPF) is an age-related lung interstitial disease that occurs predominantly in people over … IPF. Recent breakthroughs have revealed that the degree of autophagic activity influences the renewal and aging of MSCs and …
- 間葉系幹細胞におけるさまざまなレベルのオートファジー活性が特発性肺線維症の進行に関与
Therapeutic Strategies for Idiopathic Pulmonary Fibrosis–Thriving Present and Promising Tomorrow
N Gupta, M Paryani, S Patel, A Bariya, A Srivastava… - The Journal of Clinical …, 2024
… Idiopathic pulmonary fibrosis (IPF) is the most common and severe form of pulmonaryfibrosis. It is a continuous, inevitable, and lethal age-related lung disorder. The disease is erratic and progressive, with poor prognosis and limited therapeutic …
- 特発性肺線維症の治療戦略 – 現在の繁栄と有望な未来
Dual Barrier‐Penetrating Inhaled Nanoparticles for Enhanced Idiopathic Pulmonary Fibrosis Therapy
MY Yang, MM Han, L Tang, YY Bi, XN Li, JH Jeong… - Advanced Functional …, 2024
… Idiopathic pulmonary fibrosis (IPF) is an irreversible and ultimately fatal pulmonary interstitial fibrotic disease with unknown etiology.[1] The incidence of IPF is strongly correlated with age, and affected patients typically exhibit a median …
- 特発性肺線維症治療を強化するためのデュアルバリア透過性吸入ナノ粒子
[HTML] Identification and validation of potential biomarkers related to oxidative stress in idiopathic pulmonary fibrosis
X Du, Z Ma, Y Xing, L Feng, Y Li, C Dong, X Ma, R Huo… - Immunobiology, 2024
… We have demonstrated that SNCA and CYP1B1 show good diagnostic value for idiopathic pulmonary fibrosis. High levels of CYP1B1 and SNCA expression in IPF patients were associated with poor prognosis. These genes were also related to …
- 特発性肺線維症における酸化ストレスに関連する潜在的なバイオマーカーの同定と検証
Zinpentraxin Alfa for Idiopathic Pulmonary Fibrosis: The Randomized Phase III STARSCAPE Trial
L Richeldi, C Schiffman, J Behr, Y Inoue, TJ Corte… - American Journal of …, 2024
… with idiopathic pulmonary fibrosis who received zinpentraxin alfa. Objectives: To investigate the efficacy and safety of zinpentraxin alfa in patients with idiopathic pulmonaryfibrosis in a … Patients with idiopathicpulmonary fibrosis were …
- 特発性肺線維症に対するジンペントラキシン アルファ: ランダム化第 III 相 STARSCAPE 試験
[HTML] Standigm ASK™: knowledge graph and artificial intelligence platform applied to target discovery in idiopathic pulmonary fibrosis
S Han, JE Lee, S Kang, M So, H Jin, JH Lee, S Baek… - Briefings in Bioinformatics, 2024
… Given these limitations, there is a critical need to identify new therapeutic targets to treat IPFeffectively. Although the pathogenesis of IPF … In this study, given the crucial role of EMT in IPFdevelopment and progression, we identified a ranked set …
- Standigm ASK™: ナレッジグラフと人工知能プラットフォームを特発性肺線維症の標的発見に適用
Transcriptomic and network analysis identifies shared and unique pathways and immune changes across fibrotic interstitial lung diseases.
W Liu, K Huang, XZ Yang, P Wang - Aging, 2024
… Three ILDs, namely idiopathic pulmonaryfibrosis (IPF), fibrotic hypersensitivity pneumonitis (fHP), and connective tissue disease-associated ILD (CTD-ILD), exhibit similar progressive fibrosis phenotypes, yet possess distinct etiologies, encouraging …
- トランスクリプトーム解析とネットワーク解析により、線維性間質性肺疾患全体にわたる共通かつ固有の経路と免疫変化が特定
[PDF] Fibrotic lung diseases in children
B Sunman, N Kiper - Pediatric Pulmonology, 2024
… Pulmonary fibrosis (PF) is a reaction to lung injury in which there is accumulation of … Pulmonary fibrosis may present as an end stage of several childhood interstitial lung diseases (… On the other hand, idiopathic PF (IPF), the most prevalent fibrotic …
- 小児の線維性肺疾患
Asymmetric and Sustainable Synthesis of Cyclic Sulfoxides with Low Loading of Bisguanidinium Peroxomolybdate Ion-Pairing Catalyst
L Wang, Y Zhang, L Zong - ACS Sustainable Chemistry & Engineering, 2024
… in preparation of medicinally relevant molecules such as BI 1015550, a candidate drug for the treatment of idiopathic pulmonaryfibrosis. … and Drug Administration (FDA), for the treatment of idiopathic pulmonary fibrosis(IPF). The condensation of 2d with …
- ビスグアニジニウムペルオキソモリブデートイオン対触媒の低添加による環状スルホキシドの不斉かつ持続可能な合成
[PDF] Nintedanib attenuates NLRP3 inflammasome-driven liver fibrosis by targeting Src signaling
Y Wu, Q Li, YQ Wu, M Mu, H Wu, HY Tian, X Zhao - 2024
… Nintedanib, a multi-targeted tyrosine kinase inhibitor targeting the Src signaling pathway, has been approved for the treatment of idiopathicpulmonary fibrosis. However, it is still not known whether nintedanib ameliorates liver fibrosis by …
- ニンテダニブは Src シグナル伝達を標的とすることで NLRP3 インフラマソームによる肝線維症を軽減
24/02/15
[PDF] Progressive pulmonary fibrosis in patients with connective tissue disease-associated interstitial lung disease: An explorative study
J Höppner, M Wollsching-Strobel, F Schumacher… - Archives of Rheumatology, 2024
… In 2022, the ATS, ERS, JRS, and ALAT have issued a joint guideline on idiopathicpulmonary fibrosis and PPF in adults, including PFT threshold values to define PPF.Thus, the current cohort of 50 CTD-ILD patients was studied using more clearly defined …
- 膠原病関連間質性肺疾患患者における進行性肺線維症：探索的研究
ALVEOLI-IN-A-DISH: 3D-BIOPRINTED HUMAN LUNG TISSUE MODEL FOR INHALATION TOXICITY
JK Szawara - 2024
… Inhalation toxicity testing assesses chemical hazards and risks linked to respiratory tract exposure with the potential to induce interstitial lung diseases such as idiopathic pulmonaryfibrosis. With 350,000 registered chemicals and mixtures …
- ALVEOLI-IN-A-DISH: 吸入毒性のための 3D バイオプリントヒト肺組織モデル
24/02/13
Identification of Hub Genes and Prediction of Targeted Drugs for Rheumatoid Arthritis and Idiopathic Pulmonary Fibrosis
T Cui, Z Huang, K Luo, J Nie, Y Xv, Z Zeng, L Liao… - Biochemical Genetics, 2024
There is a potential link between rheumatoid arthritis (RA) and idiopathic pulmonary fibrosis(IPF). The aim of this study is to investigate the molecular processes that underlie the development of these two conditions by bioinformatics methods. The …
- ハブ遺伝子の同定と関節リウマチおよび特発性肺線維症の標的薬剤の予測
[PDF] Changes in the physical and affective dimensions of dyspnea after a home-based pulmonary rehabilitation in fibrotic idiopathic interstitial pneumonias
C Chenivesse, S Gephine, M Dornbierer, V Valentin… - ERJ Open Research, 2024
… of idiopathic pulmonary fibrosis … IPF and people with f-NSIP. However, improvements were more difficult to maintain at long-term for the former. The poorer prognosis and faster decline in IPF leading to a higher number of dropouts and …
Mechanical ventilation in patients with idiopathic pulmonary fibrosis in Korea: a nationwide cohort study.
JK Sim, SJ Moon, J Choi, JY Oh, YS Lee, KH Min… - The Korean Journal of …, 2024
… The prognosis of patients with idiopathicpulmonary fibrosis (IPF) and respiratory failure requiring mechanical ventilation is poor. Therefore… with IPF, have improved. The aim of this study was to investigate changes in the use of mechanical ventilation …
- 韓国における特発性肺線維症患者における人工呼吸器：全国コホート研究。
[PDF] Investigation into the tolerability of two antifibrotic drugs in the treatment of Idiopathic Pulmonary Fibrosis
K Biddle, R Rose'Meyer
… Idiopathic pulmonary fibrosis (IPF) is a terminal respiratory condition that causes the progressive scarring of lung tissue. There are no curative therapies for IPF however nintedanib and pirfenidone have been shown to slow disease progression …
- 特発性肺線維症の治療における 2 つの抗線維化薬の忍容性に関する研究
A POTENTIAL PARAMETER FOR ASSESSMENT OF EXERCISE CAPACITY IN PATIENTS WITH IDIOPATHIC PULMONARY DISEASE
R Aktan, K Can Tertemiz, S Yiğit, S Özalevli… - Journal of Clinical Exercise …, 2024
… with idiopathic pulmonary fibrosis (IPF). This study aims to determine whether 6MWORK has a stronger correlation with clinical parameters compared to 6MWD in male patients with IPF. METHODS: Clinical data was retrospectively analyzed from …
- 特発性肺疾患患者の運動能力を評価するための潜在的なパラメーター
Fibroblast heterogeneity in pulmonary fibrosis: a new target for therapeutics development?
K Tsoyi, IO Rosas - European Respiratory Journal, 2024
… Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease with unknown aetiology [1]. The prevalence of this devastating disease continues to increase, affecting approximately 500 per 100 000 adults over the age of 65 years in …
- 肺線維症における線維芽細胞の不均一性: 治療法開発の新たな標的?
[HTML] Nintedanib-Induced Colitis Can Mimic Inflammatory Bowel Disease
T Odah, C Karime, JG Hashash, FA Farraye - ACG Case Reports Journal, 2024
… Nintedanib is a medication that has been increasingly used for treatment of idiopathic and progressive pulmonary fibrosis. In this case series, we describe 3 patients with colitis symptoms associated with nintedanib use. Nintedanib …
- ニンテダニブ誘発性大腸炎は炎症性腸疾患を模倣する可能性がある
[PDF] Discoidin domain receptor 2 signaling through PIK3C2α in fibroblasts promotes lung fibrosis
S Ling, D Kwak, Y Takuwa, C Ge, R Franceschi… - The Journal of Pathology, 2024
… Pulmonary fibrosis, especially idiopathicpulmonary fibrosis (IPF), portends significant morbidity and mortality, and current therapeutic … To test this hypothesis, we found that primary murine fibroblasts and IPF-derived fibroblasts stimulated with …
- 線維芽細胞におけるPIK3C2αを介したディスコイジンドメイン受容体2シグナル伝達は肺線維症を促進
[HTML] InfluenZing Lung Fibrosis: Reinforcing Endothelial Surface Expression of S1PR1 to Attenuate Post–Acute Respiratory Distress Syndrome Lung Remodeling
G Kiliaris, E El Agha - American Journal of Respiratory Cell and Molecular …, 2024
… hallmarks of pulmonary fibrosis with the emergence of a profibrotic CD163 + macrophage subset that closely mimics macrophages found in patients with idiopathic pulmonary fibrosis (6). Interestingly, the same study reported that the …
- 肺線維症への影響：S1PR1の内皮表面発現の強化により急性呼吸窮迫症候群後の肺リモデリングを軽減
24/02/11
[HTML] Circular RNAs and their roles in idiopathic pulmonary fibrosis
A Surendran, C Huang, L Liu - Respiratory Research, 2024
… methodologies for detecting circRNAs and explore their diagnostic applications in IPF. Finally, we discuss the potential utility of circRNAs in the treatment of IPF. In conclusion, circRNAs hold great promise as novel biomarkers and therapeutic …
- 環状 RNA と特発性肺線維症におけるその役割
[HTML] Association of musculoskeletal involvement with lung function and mortality in patients with idiopathic pulmonary fibrosis
M Sridhar, S Bodduluri, L O'Hare, S Blumhoff… - Respiratory Research, 2024
… Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease with poor outcomes and limited therapeutic options [1]. IPF a disease of an aging population, where frailty and sarcopenia correlate with disability, hospitalizations, and mortality [2,3,4] …
- 特発性肺線維症患者における筋骨格系の肺機能および死亡との関連
[HTML] Advancing the Boundaries of Immunotherapy in Lung Adenocarcinoma with Idiopathic Pulmonary Fibrosis by a Biomimetic Proteinoid Enabling Selective Endocytosis
A Jiang, X Zheng, S Yan, J Yan, Y Yao, W He - ACS nano, 2024
… (LUAD) with idiopathic pulmonary fibrosis(IPF), which has … IPF, thus shattering the confines of ICIs immunotherapy. The reported EMS-PDBP collectively offers a potential strategy for immune reactivation to overcome the limitations of …
- 選択的エンドサイトーシスを可能にする生体模倣プロテイノイドによる特発性肺線維症を伴う肺腺癌における免疫療法の限界を前進
[PDF] Mitochondrial DNA in bronchoalveolar lavage fluid is associated with the prognosis of idiopathic pulmonary fibrosis: a cohort study
J Fukihara, K Sakamoto, Y Ikeyama, T Furukawa… - 2024
… ) of idiopathic pulmonary brosis (IPF) patients. While increased levels of serum mtDNA have been reported to be linked to disease progression and the future development of acute exacerbation (AE) of IPF (AE-IPF)… -mtDNA levels and other …
[PDF] Inspiratory Crackles in Idiopathic Pulmonary Fibrosis–Friend or Foe for Early Diagnosis?
D Lang, B Lamprecht, NM Bishop, M Sterclova… - 2024
… Velcro crackles (VCR) are frequent in idiopathic pulmonary brosis (IPF) patients and have … IPF diagnosis was recorded by the treating physician. Patients were excluded from this analysis if the date of diagnosis was unknown or if the IPF …
- 特発性肺線維症における吸気パチパチ音―早期診断にとって敵か味方か?
[PDF] N-Phenyl-2-Pyridone-Derived Endoperoxide Exhibiting Dual Activity by Suppressing both Lung Cancer and Idiopathic Pulmonary Fibrosis
L Wang, H Wu, Z Liu, Y Li, Y Si, R Sun, Y Nie, Y Qiao… - 2024
… -2-pyridone as an analogue of pirfenidone (Approved drug for treatment of idiopathicpulmonary fibrosis), showing great potential for treating non-small cell lung cancer and idiopathic pulmonary fibrosis. In aqueous solution, E5 could …
- 肺がんと特発性肺線維症の両方を抑制する二重活性を示す N-フェニル-2-ピリドン由来のエンドペルオキシド
Use of 6‐minute walk distance to predict lung transplant‐free survival in fibrosing non‐IPF interstitial lung diseases
U Zanini, F Luppi, K Kaur, N Anzani, G Franco… - Respirology, 2024
… patients with fibrosing non-idiopathicpulmonary fibrosis (IPF) interstitial lung … idiopathic pulmonary fibrosis (IPF), characterized by progressive parenchymal lung fibrosis and functional decline. Despite the significant variability in disease course …
- 線維化性非IPF間質性肺疾患における肺移植なしの生存率を予測するための6分の歩行距離の使用
Missing Nuts and Bolts: Translating Pulmonary Fibrosis from Preclinical Murine Models to Human Clinical Trials
IK Sundar, SM Matson - Lung, 2024
… idiopathic pulmonary fibrosis (IPF) drugs from preclinical trials in murine models to clinical trials in humans is highlighted in a recent editorial in The Lancet Respiratory Medicine [1]. The editorial appropriately focuses on the important impact …
- 不足している基本事項: 肺線維症を前臨床マウスモデルからヒト臨床試験に移行
Neutrophil–lymphocyte ratio being associated with mortality risk in patients receiving antifibrotic therapy
S Takuma, Y Suzuki, M Kono, H Hasegawa… - Respiratory Medicine, 2024
… Patients with a spectrum of progressive pulmonary fibrosis (PPF), including idiopathicpulmonary fibrosis (IPF), have a progressive fibrosing clinical phenotype characterized by an increasing extent of fibrosis shown on high-resolution computed …
- 好中球とリンパ球の比率は抗線維化療法を受けている患者の死亡リスクと関連
[HTML] Guideline Recommendations and Real-World Practice: Bridging the Famous Divide
AU Wells, C Ravaglia - CHEST, 2024
… This is exemplified by the widely used HRCT categories recommended in current guidelines for the diagnosis of idiopathic pulmonaryfibrosis (IPF): typical usual interstitial pneumonia (UIP), probable UIP, indeterminate, and indicative of an …
- ガイドラインの推奨事項と現実世界の実践: 有名な格差を埋める
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特発性肺線維症( idiopathic pulmonary fibrosis (IPF) )関連の学術的情報収集してシェアしています。Google Scholar SearchのUpdateを定期的に掲載しています。GoogleのAIが一定の重み付けはしているとは思いますが、玉石混交です。
当面、毎週アラートの内容をアップしていこうと思います。
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