ChatGPTを活用して業務のAI化を進めています。プロンプトエンジニアリングの専門家です！と、名乗れるレベルではありませんが、かなり色々使いこなしてきています。この１年、病気で失われた能力は、別な能力を発達させる、進化することで生き残っていこうと思います。
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23/12/16
[HTML] EZY-1 inhibits idiopathic pulmonary fibrosis by regulating M2-type macrophage differentiation
J Wu, M Tu, T Wei, X Huang, J Chen, Y Jia, L He… - Journal of Functional Foods, 2024
… with idiopathic pulmonary fibrosis (IPF) initiation. Herein, we show that EZY-1, a novel peptide derived from Eucheuma, regulates macrophage differentiation to inhibit IPF. … Idiopathic pulmonary fibrosis (IPF) is a form of interstitial lung disease (ILD) …
- EZY-1はM2型マクロファージの分化を制御することにより特発性肺線維症を抑制
[HTML] Survival differences in rheumatoid arthritis interstitial lung disease and idiopathic pulmonary fibrosis may be explained by delays in presentation: results from …
S Dubey, F Woodhead - Rheumatology International, 2023
… ) has a better prognosis compared to idiopathic pulmonary fibrosis (IPF). Recent data suggest … and outcomes in patients with RA-ILD and IPF prior to antifibrotic use in the Coventry ILD … with IPF, 34 patients with RA-ILD and 48 patients with …
- 関節リウマチ、間質性肺疾患、特発性肺線維症の生存率の違いは発症の遅れで説明できる可能性：英国の単中心研究における多変量解析の結果
Pulse versus non-pulse corticosteroid therapy in patients with acute exacerbation of idiopathic pulmonary fibrosis
K Hyung, JH Lee, JY Kim, SM Choi, J Park - Respirology (Carlton, Vic.)
… for the treatment of acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF); however, the … Methods: We retrospectively analysed 238 patients with AE-IPF treated with corticosteroids … within 7 days of hospitalization for AE-IPF, the patients …
Betanin protects against bleomycin-induced pulmonary fibrosis by regulating the NLRP3/IL-1β/TGF-β1 pathway-mediated epithelial-to-mesenchymal transition
NA Abd Elrazik, SA Helmy - Food & Function, 2024
… disorders, idiopathic pulmonary fibrosis(IPF) is acknowledged to exhibit the most severe manifestations with the poorest clinical outcomes. IPF is a … Increasing evidence suggests that the epithelial–mesenchymal transition (EMT) plays a crucial …
- ベタニンは、NLRP3/IL-1β/TGF-β1 経路を介した上皮から間葉への移行を調節することにより、ブレオマイシン誘発性肺線維症を防御
[HTML] Activation of ILC2s through constitutive IFNγ signaling reduction leads to spontaneous pulmonary fibrosis
N Otaki, Y Motomura, T Terooatea, S Thomas Kelly… - Nature Communications, 2023
… Among the IIPs, idiopathic pulmonaryfibrosis (IPF), a progressive disease of unknown cause, has poor prognosis, with no effective … those observed in the human IPF patient samples that we analyze, thereby underscoring their utility in …
- 構成的な IFNγ シグナル伝達の減少による ILC2 の活性化は、自然発生的な肺線維症を引き起こす
Sequential approach to interstitial lung disease: An autoimmune perspective
CB Samper, NF Correa-González, CAC Preciado… - Revista Colombiana de …, 2023
… The diagnostic approach should emphasize defining whether the patient has idiopathicpulmonary fibrosis (IPF), or if it is a secondary ILD; especially autoimmune diseases or hypersensitivity pneumonitis. Regarding the therapeutic approach …
- 間質性肺疾患への逐次アプローチ: 自己免疫の観点から
[PDF] Role of pterostilbene in the regulation of notch signaling pathway of pulmonary fibrosis; comprehensive bioinformatics analysis model and in vivo study
Y Peng, X Xu, Y Zhang, Y Zhang - 2023
… To investigate the role of the Notch pathway in idiopathic pulmonary brosis (IPF) patients and of pterostilbene in Notch pathway regulation employing systematic bioinformatic model followed by the analysis of pterostilbene role in alleviating the …
- 肺線維症のノッチシグナル伝達経路の調節におけるプテロスチルベンの役割。 包括的なバイオインフォマティクス解析モデルと in vivo 研究
[HTML] Ginkgolide B Blocks Vascular Remodeling after Vascular Injury via Regulating Tgfβ1/Smad Signaling Pathway
Q Wang, S Ni, L Ling, S Wang, H Xie, Z Ren - Cardiovascular Therapeutics, 2023
… Moreover, the beneficial effect of GB is abolished after incubated with pirfenidone (PFD, a drug for idiopathic pulmonary fibrosis, IPF), which can inhibit Tgfβ1. In Tgfβ1-/- mice, treatment with pirfenidone capsules and Yinxingneizhi Zhusheye (including …
- ギンコライド B は、Tgfβ1/Smad シグナル伝達経路の制御を介して血管損傷後の血管リモデリングをブロック
[PDF] Connective tissue disease‐associated pulmonary hypertension: A comprehensive review
V Khangoora, EJ Bernstein, CS King, OA Shlobin - Pulmonary Circulation, 2023
… Clinical trial data for sildenafil in ILDs is somewhat mixed and primarily originates from studies in patients with idiopathic pulmonaryfibrosis (IPF). A few studies of sildenafil in IPFand fibrotic ILD with associated PH have shown clinical …
- 結合組織病に関連する肺高血圧症：包括的なレビュー
23/12/14
[PDF] Predictive biomarkers of disease progression in idiopathic pulmonary fibrosis
W Zhu, C Liu, C Tan, J Zhang - Heliyon, 2023
… Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial disease that cannot be cured, 34 … exacerbation of idiopathic pulmonaryfibrosis as an outcome measure in clinical trials. … counts as a potential prognostic marker for idiopathic pulmonary …
- 特発性肺線維症における疾患進行の予測バイオマーカー
Idiopathic Pulmonary fibrosis prognosis
P Ghadekar, A Uzair, A More, P Ratnaparkhi, S Raj… - AIP Conference …, 2023
… If the Pulmonary fibrosis is present in one’s lungs, it is very difficult to cure it. On the other … Genetic studies raise hope for help for detecting Pulmonary fibrosis disease at an early age. … detects or projects the growth of the pulmonaryfibrosis …
- 特発性肺線維症の予後
[HTML] Neutrophil–lymphocyte ratio in patients with idiopathic pleuroparenchymal fibroelastosis
Y Suzuki, M Kono, H Hasegawa, D Hashimoto… - BMJ Open Respiratory …, 2023
… Associations between blood leucocyte levels and mortality have been reported in patients with idiopathic pulmonary fibrosis; therefore, we … with idiopathic pleuroparenchymal fibroelastosis (iPPFE) is similar to or worse than that of patients …
- 特発性胸膜実質線維弾性症患者における好中球とリンパ球の比率
Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis
S Halappanavar, M Sharma, S Solorio-Rodriguez… - 2023
… (BO) (‘popcorn lung’), and chronic beryllium disease have pulmonary fibrosis as a main or secondary symptom. In addition, exposure to … (AO) of pulmonary fibrosis. Idiopathicpulmonary fibrosis (IPF) is the most common type of pulmonary fibrosis in …
- 肺線維症を引き起こす肺常在細胞膜成分との物質相互作用
[HTML] The usual Interstitial pneumonia pattern in autoimmune rheumatic diseases
F Luppi, A Manfredi, P Faverio, MB Andersen, F Bono… - BMC Pulmonary Medicine, 2023
… Pirfenidone attenuates the production of transforming growth factor-β1 (TGF-β1), a key profibrotic and pro-inflammatory cytokine implicated in idiopathic pulmonary fibrosis(IPF). Some evidence also suggests that pirfenidone downregulates pro-inflammatory …
- 自己免疫性リウマチ性疾患における通常の間質性肺炎パターン
ISABELA studies: plasma exposure and target engagement do not explain the lack of efficacy of ziritaxestat in patients with IPF
A Taneja, G Jentsch, S Delage, MJ Randall… - Clinical Pharmacology & …
… Autotaxin (ATX) contributes to the production of lysophosphatidic acid (LPA), which is associated with fibrosis development in idiopathic pulmonary fibrosis (IPF). The ATX inhibitor, ziritaxestat, failed to reduce decline in forced vital capacity (FVC) …
- ISABELA 研究：血漿曝露と標的関与は、IPF 患者におけるジリタキセスタットの有効性の欠如を説明できない
Expansion of distinct peripheral blood myeloid cell subpopulations in patients with rheumatoid arthritis-associated interstitial lung disease
JA Poole, KE Cole, GM Thiele, JE Talmadge… - International …, 2024
… idiopathic pulmonary fibrosis (IPF) is characterized by UIP findings in the absence of autoimmunity. Although there have been improvements in therapeutic approaches for ILD and the associated pulmonary fibrosis… in RA and idiopathic (non-autoimmune) …
- 関節リウマチ関連間質性肺疾患患者における異なる末梢血骨髄細胞亜集団の拡大
23/12/12
Spatial targeting of fibrosis-promoting macrophages with nanoscale metal-organic frameworks for idiopathic pulmonary fibrosis therapy
J Hou, Y Cong, J Ji, Y Liu, H Hong, X Han - Acta Biomaterialia, 2023
… as a challenging yet effective approach for the treatment of idiopathic pulmonary fibrosis(IPF). Here, nanocarriers composed of Mn-curcumin … further improving IPF therapy. This study presents a novel strategy with promising prospects for molecular-targeted …
[HTML] Acute exacerbation of idiopathic pulmonary fibrosis after bivalent (tozinameran and famtozinameran) mRNA COVID-19 vaccination
K Tsumura, Y Zaizen, S Umemoto, S Tsuneyoshi… - Respiratory Medicine Case …, 2023
… for an alternative diagnosis according to IPFdiagnosis guidelines [11], but we also considered AE-IPF. Bronchoscopy was necessary to … that the previously reported interstitial pneumonia was idiopathic pulmonary fibrosis and confirmed that …
- 二価（トジナメランおよびファムトジナメラン）mRNA COVID-19ワクチン接種後の特発性肺線維症の急性増悪
[PDF] Factors associated with mortality in cases of idiopathic pulmonary fibrosis with mild to moderate functional impairment
A Şengül, BA Özyürek, F Coşkun, O Yazıcı, F Bozkuş… - Eurasian Journal of …, 2023
… BACKGROUND AND AIM: Idiopathicpulmonary fibrosis (IPF) is a chronic and progressive lung disease with a poor prognosis, … in our IPF patient cohort. METHODS: Our multicenter, retrospective cohort study reviewed the records of 169 …
- 軽度から中等度の機能障害を伴う特発性肺線維症の場合の死亡率に関連する要因
Serum amyloid A: a new biomarker in Idiopathic Pulmonary Fibrosis
L Vietri - 2023
… in the IPF and AE-IPF groups was statistically significant (p<0.002). By performing a ROC curve of SAA in AE-IPF vs stable IPF we … By performing a ROC curve of SAA in AE-IPF vs stable IPF we detected a cut-off 48,84 mcg/ml highly …
- 血清アミロイド A: 特発性肺線維症の新しいバイオマーカー
Fibroblast activation protein and disease severity, progression, and survival in idiopathic pulmonary fibrosis
TS Prior, N Hoyer, JR Davidsen, SB Shaker… - 2023
… Idiopathic pulmonary fibrosis (IPF) is characterized by progressive fibrosis in the lungs. Activated fibroblasts play a central role in … , multicenter, real-world cohort of patients with IPF. Methods Patients with IPF were recruited from the tertiary …
- 線維芽細胞活性化タンパク質と特発性肺線維症における疾患の重症度、進行、生存率
Effect of acute kidney injury on near-term prognosis of the recipients with idiopathic pulmonary fibrosis after lung transplantation
C HU, J WANG, X LI, H YU, B XU, D HUANG, F LIU… - Chinese Journal of Organ …, 2023
… the effect of acute kidney injury(AKI)on near-term survival after lung transplantation(LT)in patients with idiopathic pulmonaryfibrosis(IPF). … As a common complication post-LT, AKI significantly affects near-term postoperative …
- 肺移植後の特発性肺線維症レシピエントの短期予後に対する急性腎損傷の影響
[PDF] Albendazole ameliorates aerobic glycolysis in myofibroblasts to reverse pulmonary fibrosis
C Zeng, H Yue, C Wang, X Ju, T Wang, X Fu, Q Zhou… - 2023
… Idiopathic pulmonary brosis (IPF) is a chronic and lethal lung disorder for which effective treatments remain limited. Recent investigations … , the key cells responsible for generating and depositing extracellular matrix proteins within the …
- アルベンダゾールは筋線維芽細胞の好気性解糖を改善して肺線維症を逆転さる
[HTML] A novel mechanoeffector role of fibroblast S100A4 in myofibroblast transdifferentiation and fibrosis
BD Southern, H Li, H Mao, JF Crish, LM Grove… - Journal of Biological Chemistry
… , such as idiopathic pulmonary fibrosis(IPF). We … pulmonary fibrosis, and S100A4 expression is dysregulated in IPF. Our data reveal a novel mechanosensor/effector role for endogenous fibroblast S100A4 in inducing cytoskeletal redistribution in …
- 筋線維芽細胞の分化転換および線維化における線維芽細胞S100A4の新規メカノエフェクターの役割
The microbiome: an integral player in immune homeostasis and inflammation in the respiratory tract
O Perdijk, R Azzoni, BJ Marsland - Physiological Reviews, 2023
… IPF – Idiopathic pulmonary fibrosis 47 … Gastrointestinal reflux is also associated with lung diseases including asthma, Idiopathic 342 Pulmonary Fibrosis (IPF), Chronic Obstructive Pulmonary Disease (COPD) and Cystic 343 …
- マイクロバイオーム: 免疫恒常性と気道の炎症に不可欠な役割
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特発性肺線維症( idiopathic pulmonary fibrosis (IPF) )関連の学術的情報収集してシェアしています。Google Scholar SearchのUpdateを定期的に掲載しています。GoogleのAIが一定の重み付けはしているとは思いますが、玉石混交です。
当面、毎週アラートの内容をアップしていこうと思います。
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