ChatGPTを活用して業務のAI化を進めています。プロンプトエンジニアリングの専門家です！と、名乗れるレベルではありませんが、かなり色々使いこなしてきています。この１年、病気で失われた能力は、別な能力を発達させる、進化することで生き残っていこうと思います。
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23/11/25
[HTML] Elamipretide (SS-31) Attenuates Idiopathic Pulmonary Fibrosis by Inhibiting the Nrf2-Dependent NLRP3 Inflammasome in Macrophages
Y Nie, J Li, X Zhai, Z Wang, J Wang, Y Wu, P Zhao… - Antioxidants, 2023
… Idiopathic pulmonary fibrosis (IPF) is a progressive fatal lung disease with a limited therapeutic strategy. … -31 in IPF through antagonizing macrophage activation and revealed a novel molecular mechanism accounting for the therapeutic …
- エラミプレチド (SS-31) は、マクロファージの Nrf2 依存性 NLRP3 インフラマソームを阻害することにより、特発性肺線維症を軽減
[HTML] Study on Potential Differentially Expressed Genes in Idiopathic Pulmonary Fibrosis by Bioinformatics and Next-Generation Sequencing Data Analysis
M Giriyappagoudar, B Vastrad, R Horakeri, C Vastrad - Biomedicines, 2023
… Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with reduced quality … of IPF and related key genes, so as to investigate the potential molecular pathogenesis of IPF … genes (DEGs) were identified between IPF and …
- バイオインフォマティクスと次世代シーケンシングデータ解析による特発性肺線維症における発現差の可能性のある遺伝子の研究
[PDF] CAUSES OF PULMONARY FIBROSIS
AA Dalimov - International Multidisciplinary Journal for Research & …, 2023
… idiopathic pulmonary fibrosis, including viruses and exposure to tobacco smoke. Also, some forms of idiopathic pulmonary fibrosisrun in families, and heredity may play a role in idiopathic … if GERD may be a risk factor for idiopathic pulmonary …
- 肺線維症の原因
[HTML] Evaluation of common protein biomarkers involved in the pathogenesis of respiratory diseases with proteomic methods: A systematic review
H Rezaeeyan, M Arabfard, HR Rasouli, A Shahriary… - Immunity, Inflammation and …, 2023
… In this study, for the first time, we examined the protein markers involved in the pathogenesis of chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, asthma, bronchiolitis obliterans, and chemical warfare victims exposed to …
- プロテオミクス法による呼吸器疾患の発症に関与する一般的なタンパク質バイオマーカーの評価: 系統的レビュー
[HTML] … phagocytosis-evading inhaled microgels incorporating nintedanib-PLGA nanoparticles and pirfenidone-liposomes for improved treatment of pulmonary fibrosis
WT Lee, H Lee, J Kim, Y Jung, E Choi, JH Jeong… - Bioactive Materials, 2024
… Idiopathic pulmonary fibrosis (IPF) is a chronic inflammatory and fibrotic response-driven … efficacy in a bleomycin-induced pulmonaryfibrosis mouse presumably due to prolonged lung … Idiopathic pulmonary fibrosis (IPF) is a progressive and …
- 肺線維症の治療を改善するニンテダニブ-PLGAナノ粒子とピルフェニドン-リポソームを組み込んだ肺胞マクロファージの食作用を回避する吸入ミクロゲル
[HTML] Investigation of a UPR-Related Gene Signature Identifies the Pro-Fibrotic Effects of Thrombospondin-1 by Activating CD47/ROS/Endoplasmic Reticulum Stress …
JH Zhan, J Wei, L Liu, YT Xu, H Ji, CN Wang, YJ Liu… - Antioxidants, 2023
… Unfolded protein response (UPR) signaling and endoplasmic reticulum (ER) stress have been linked to pulmonary fibrosis. However, the relationship between UPR status and pulmonary function and prognosis in idiopathicpulmonary fibrosis (IPF) …
- UPR 関連遺伝子シグネチャの研究により、肺線維芽細胞の CD47/ROS/小胞体ストレス経路を活性化することによるトロンボスポンジン 1 の線維化促進効果が特定
Traditional Herbal Medicines, Bioactive Compounds, and Plant Products as Therapeutic Approach Against Interstitial Lung Disease
L Sinha, S Karmakar - Genetic Manipulation of Secondary Metabolites in …, 2023
… A TCM regime known as BuqiHuoxueTongluo formula (BHTF) has shown promise as a therapeutic agent for idiopathic pulmonaryfibrosis (IPF). The composition of BHTF includes Astragali Radix (Huangqi, 30 g), Lonicerae japonicae …
- 間質性肺疾患に対する治療法としての伝統的な漢方薬、生理活性化合物、植物製品
[PDF] MUC5B Mutation Causes Mucociliary Dys-function and Primary Ciliary Dyskinesia Like Illness in a Saudi Girl: A Case Report
G Mukhtar - Ann Clin Med Case Rep, 2023
… tissue from unaffected subjects and patients with idiopathic pulmonary fibrosis (IPF). In patients with IPF, excess MUC5B protein is especially … However, it remains unclear how MUC5B leads to the development of IPF in adult. In mice, MUC5B is …
Chinese expert consensus on multidisciplinary discussion of interstitial lung disease
CT Society, Chinese Medical Association - Zhonghua jie he he hu xi za zhi= Zhonghua …
… Specific conditions:(1) Suspected idiopathicpulmonary fibrosis should be diagnosed by a standardized MDD process. (2) Suspected idiopathic interstitial … Progressive pulmonaryfibrosis: Use ILD-MDD to determine whether an ILD patient …
- 間質性肺疾患に関する学際的な議論に関する中国の専門家の合意
23/11/23
[HTML] The causal relationship between physical activity, sedentary time and idiopathic pulmonary fibrosis risk: a Mendelian randomization study
W Lei, M Yang, Z Yuan, R Feng, X Kuang, Z Liu… - Respiratory Research, 2023
… time are associated with idiopathicpulmonary fibrosis (IPF) risk. However, the causality between them still requires further investigation. Therefore, our study aimed to investigate the causal effect of physical activity (PA) and sedentary time on …
- 身体活動、座りっぱなしの時間、特発性肺線維症のリスクとの因果関係：メンデルランダム化研究
[PDF] A prognostic model of idiopathic pulmonary fibrosis was constructed based on macrophage-related genes and mitochondria-related genes
Y Bao, S Yang, H Zhao, X Zhu, Y Wang, K Li, X Liu… - 2023
… of idiopathic pulmonary brosis (IPF). However, the mechanism of macrophages and mitochondria in IPF is not fully understood. … lls the gap in prognostic biomarkers of IPF, can better predict the disease progression and prognosis of …
- マクロファージ関連遺伝子とミトコンドリア関連遺伝子に基づいて特発性肺線維症の予後モデルを構築
Cancer Cases: Macrocytic Anemia and Idiopathic Pulmonary Fibrosis
ST Li, TM Brewer, R Moore, C Eng, J Ngeow - Genomics in the Clinic, 2024
… He also has developed MDS as well as idiopathic pulmonary fibrosis. … the most common environmental causes for idiopathicpulmonary fibrosis, a small percentage of those … In view of his clinical diagnosis of MDS and pulmonary fibrosis, as well …
- がん症例：大球性貧血と特発性肺線維症
[PDF] Idiopathic Fibrotic Nonspecific Interstitial Pneumonia with Cicatricial Organizing Pneumonia and Intraluminal Pulmonary Ossification Containing Bone Marrow
K Morikawa, M Toyoshima, K Koda, T Suda - Internal Medicine, 2024
… in these patients is significantly lower than in patients with IPF (6). In addition, Kim et al. … its prevalence in NSIP is significantly lower than that in IPF (6). In addition, CiOP and DPO … , similar to that involved in the pathogenesis of IPF, may have resulted …
- 瘢痕性器質性肺炎および骨髄を含む腔内肺骨化症を伴う特発性線維性非特異的間質性肺炎
[HTML] Factors associated with rapid progression in fibrotic interstitial lung disease
X Chen, Q Ji, Q Yao, Y Zhou - Heliyon, 2023
… (PPF) in 2022 [5], which was defined as at least two of three criteria (worsening symptoms, radiological progression, and physiological progression) occurring within the past year with no alternative explanation in a patient with an ILD other than …
- 線維性間質性肺疾患の急速な進行に関連する要因
MDA5-autoimmunity and Interstitial Pneumonitis Contemporaneous with the COVID-19 Pandemic (MIP-C)(preprint)
K Iqbal, S Sinha, P David, G De Marco, S Taheri… - 2023
… Gene expression patterns in COVID-19 were compared with autoimmune lung disease and idiopathic pulmonary fibrosis (IPF) to gain … Transcriptomic studies showed strong IFIH1 (gene encoding for MDA5) induction in COVID-19 and …
In vivo pharmacokinetic and pharmacodynamic study of inhalable pirfenidone microparticles prepared via high-energy bead milling
JH Kang, JC Choi, WY Song, J Choi, SH Lee, CW Park - Journal of Pharmaceutical …, 2023
… Idiopathic pulmonary fibrosis (IPF), a type of idiopathic interstitial pneumonia of unknown etiology, has no treatment available till date. It is characterized by an aberrant accumulation of fibroblasts and progressive abnormal remodeling of the …
- 高エネルギービーズミリングによって調製された吸入可能なピルフェニドン微粒子の in vivo 薬物動態学的および薬力学的研究
23/11/21
[HTML] Spatially distinct molecular patterns of gene expression in idiopathic pulmonary fibrosis
RZ Blumhagen, JS Kurche, CD Cool, AD Walts… - Respiratory Research, 2023
… Among the 19 IPF cell types that were observed with the IPF reference, we observed fewer ciliated cells (p = 0.007) and greater pericytes (p = 7 × 10 −5 ) between IPF and controls with histologically normal lung tissue in the normal …
- 特発性肺線維症における空間的に異なる遺伝子発現の分子パターン
MMP19 Variants in Familial and Sporadic Idiopathic Pulmonary Fibrosis
Y Fan, C Zheng, R Ma, J Wang, S Yang, Q Ye - Lung, 2023
… Gene variants have been identified in patients with familial or sporadic idiopathic pulmonaryfibrosis (IPF). These variants may partially account for the genetic risk of IPF. The aim of this study was to identify potential genes involved in both familial and …
- 家族性および散発性特発性肺線維症におけるMMP19変異体
Inhaled pulmonary surfactant biomimetic liposomes for reversing idiopathic pulmonary fibrosis through synergistic therapeutic strategy
B Wang, Y Gao, M Xue, M Wang, Z Zhang, L Zhang… - Biomaterials, 2023
… Idiopathic pulmonary fibrosis (IPF) stands as a highly heterogeneous and deadly lung disease, yet the available treatment options remain limited. Combining myofibroblast inhibition with ROS modulation in damaged AECs offers a …
- 相乗的な治療戦略を通じて特発性肺線維症を逆転させるための吸入肺サーファクタント生体模倣リポソーム
Harnessing the Translational Power of Bleomycin Model: New Insights to Guide Drug Discovery for Idiopathic Pulmonary Fibrosis
A Murgo, F Bignami, G Federico, G Villetti, M Civelli… - Frontiers in Pharmacology
… Despite the wide variety of different in vivo models for IPF, these preclinical models have shown limitations that may significantly impair … )-induced pulmonary fibrosis mouse model, introducing and validating novel readouts to evaluate the …
- ブレオマイシン モデルのトランスレーショナル パワーの活用: 特発性肺線維症の創薬を導く新たな洞察
[PDF] Assessment of causal associations among gut microbes, plasma metabolites and idiopathic pulmonary fibrosis: a bidirectional Mendelian randomization study
W Du, X wei Wu, J Wu, B yu Zhang, L sheng Chen, X Yi - 2023
… is known as idiopathic pulmonary fibrosis. A growing body of research indicates that the causes of idiopathic pulmonary fibrosis may include … However, uncertainty exists regarding the causative link between idiopathicpulmonary fibrosis, plasma …
Identifying the Link between Serum VEGF and KL-6 Concentrations: A Correlation Analysis for Idiopathic pulmonary fibrosis interstitial lung disease Progression
S Luo - Frontiers in Medicine
… IPF-ILD. Specifically, it assessed their correlation with PaO2, a measure of pulmonary gas function, to provide diagnostic and prognostic indicators. Methods: Patients with IPF-… serum marker KL-6 and the degree of fibrotic damage in IPF-ILD …
- 血清VEGFとKL-6濃度の間の関連性の特定：特発性肺線維症と間質性肺疾患の進行に関する相関分析
Inhalation Lenalidomide-Loaded Liposome for Bleomycin-Induced Pulmonary Fibrosis Improvement
Z Luo, L Ji, H Liu, Y Sun, C Zhao, X Xu, X Gu, X Ai… - AAPS PharmSciTech, 2023
… Idiopathic pulmonary fibrosis (IPF) is a progressive, fibrotic interstitial lung disease with … The effectiveness of lenalidomide (Len) liposomal lung delivery in idiopathic pulmonaryfibrosis was … Inhalation Len-Lip provided a reference for the …
- ブレオマイシン誘発性肺線維症改善のための吸入レナリドマイド充填リポソーム
[HTML] ACSS3 regulates the metabolic homeostasis of epithelial cells and alleviates pulmonary fibrosis
L Wang, H Yuan, W Li, P Yan, M Zhao, Z Li, H Zhao… - Biochimica et Biophysica …, 2024
… Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease of unknown etiology. The emerging evidence demonstrates that metabolic homeostatic imbalance caused by repetitive injuries of the alveolar epithelium is the …
- ACSS3は上皮細胞の代謝恒常性を調節し、肺線維症を軽減
[PDF] Cellular and molecular mechanisms of fibrosis and resolution in bleomycin-induced pulmonary fibrosis mouse model revealed by spatial transcriptome analysis
Q Li, Y Wang, L Ji, J He, H Liu, W Xue, H Yue, R Dong… - Heliyon
… essential process of pulmonary fibrosis and, more importantly, prove its efficiency as an IPFmodel. Studies focusing on familial pulmonaryfibrosis or genome-wide association studies have identified genetic factors related to idiopathic pulmonary …
- 空間トランスクリプトーム解析により明らかになったブレオマイシン誘発性肺線維症マウスモデルにおける線維症と回復の細胞および分子機構
[HTML] Derivation and validation of a non-invasive prediction tool to identify pulmonary hypertension in patients with IPF: evolution of the model FORD
SD Nathan, A Chandel, Y Wang, J Xu, L Shao… - The Journal of Heart and …, 2023
… The administration of inhaled prostanoids to patients with pulmonary hypertension (PH) related to idiopathic pulmonary fibrosis (IPF) and other fibrotic interstitial lung diseases improves functional outcomes. Selection of patients with …
- IPF患者の肺高血圧症を特定するための非侵襲的予測ツールの導出と検証：モデルFORDの進化
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特発性肺線維症( idiopathic pulmonary fibrosis (IPF) )関連の学術的情報収集してシェアしています。Google Scholar SearchのUpdateを定期的に掲載しています。GoogleのAIが一定の重み付けはしているとは思いますが、玉石混交です。
当面、毎週アラートの内容をアップしていこうと思います。
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