IPF Weekly Update - AIとIPFと癒しの音楽

ChatGPTを活用して業務のAI化を進めています。プロンプトエンジニアリングの専門家です！と、名乗れるレベルではありませんが、かなり色々使いこなしてきています。この１年、病気で失われた能力は、別な能力を発達させる、進化することで生き残っていこうと思います。

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23/11/18

Mapping the genetic architecture of idiopathic pulmonary fibrosis: meta-analysis and epidemiological evidence of case-control studies

P Singh, D Guin, B Pattnaik, R Kukreti - Gene, 2023

… Idiopathic pulmonary fibrosis (IPF) is a rare and devastating fibrotic lung disorder with unknown etiology. Although it is believed that … and pathways implicated in IPF pathogenesis through a two-staged systematic literature search of genetic …

特発性肺線維症の遺伝子構造のマッピング: 症例対照研究のメタ分析と疫学的証拠

[HTML] Exploring the Role of Biomarkers Associated with Alveolar Damage and Dysfunction in Idiopathic Pulmonary Fibrosis—A Systematic Review

AS Zamfir, ML Zabara, RI Arcana, TA Cernomaz… - Journal of Personalized …, 2023

Background: Idiopathic pulmonary fibrosis(IPF) is one of the most aggressive forms of interstitial lung diseases (ILDs), marked by an … of the existing biomarkers for IPF. Results: Signs of epithelial cell damage hold promise as relevant biomarkers for IPF …

特発性肺線維症における肺胞損傷および機能不全に関連するバイオマーカーの役割の探索—系統的レビュー

Neighborhood Health and Outcomes in Idiopathic Pulmonary Fibrosis

AM DeDent, HR Collard, N Thakur - Annals of the American Thoracic Society, 2023

… Rationale: Living in a disadvantaged neighborhood has been associated with worse survival in idiopathic pulmonary fibrosis (IPF), however prior studies have only examined the impact of neighborhood health on outcomes in IPF as a …

近隣地域の健康と特発性肺線維症の転帰

[PDF] Factors associated with mortality in cases of idiopathic pulmonary fibrosis with mild to moderate functional impairment

A Şengül, BA Özyürek, F Coşkun, O Yazıcı, F Bozkuş… - Eurasian Journal of …, 2023

… BACKGROUND AND AIM: Idiopathicpulmonary fibrosis (IPF) is a chronic and progressive lung disease with a poor prognosis, … in our IPF patient cohort. METHODS: Our multicenter, retrospective cohort study reviewed the records of 169 …

軽度から中等度の機能障害を伴う特発性肺線維症の場合の死亡率に関連する要因

[HTML] Unraveling FOXO3a and USP18 Functions in Idiopathic Pulmonary Fibrosis through Single-Cell RNA Sequencing of Mouse and Human Lungs

B Wang, J Pan, Z Liu - Global Medical Genetics, 2023

… Idiopathic pulmonary fibrosis (IPF) is a progressive and often fatal lung disorder … of IPF has been observed to increase, affecting predominantly older adults, especially those between 60 and 75 years, with a higher prevalence in men than …

マウスとヒトの肺の単細胞 RNA シーケンスによる特発性肺線維症における FOXO3a と USP18 の機能の解明

Machine learning identified MDK score has prognostic value for idiopathic pulmonary fibrosis based on integrated bulk and single cell expression data

S Zhang, L Wang, H Wang, J Wu, H Cai, C Mo, J Yang - Frontiers in Genetics

… Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease that poses a … ) gene has the potential to serve as a marker of IPF, because its cellular communicating genes are … Our findings offer valuable insights into the …

統合されたバルクおよび単一細胞発現データに基づいて、機械学習により特発性肺線維症の予後価値があると特定された MDK スコア

Statin Use, Lipids, and 3-Hydroxy-3-Methyl-Glutaryl Coenzyme A Reductase Inhibition on Risk of Idiopathic Pulmonary Fibrosis

SS Zhao, P Alton, K Rogers, DM Hughes - Clinical Therapeutics

… causal link between serum lipid fractions and IPF risk. Lipids and BMI are common causes of both statin-use and IPF, and may be a source … Our findings apply to IPF risk and not prognosis; thus, the role of statins on outcomes among …

特発性肺線維症のリスクに対するスタチンの使用、脂質、および 3-ヒドロキシ-3-メチル-グルタリルコエンザイム A レダクターゼ阻害

[PDF] Interim Analysis of AIR-An Open-label, Single Arm, 36-week Phase 2a Trial of the Angiotensin II Type 2 Receptor Agonist (ATRAG), C21, in Individuals with IPF

C Ganslandt, R Batta, TM Maher, PL Molyneaux…

… Idiopathic pulmonary fibrosis (IPF) is a chronic and fatal interstitial lung disease. The incidence is estimated to be 2.8 to 19 per 100,000 … declining lung function associated with IPF and available therapies are poorly tolerated. Current therapies …

IPF患者を対象としたアンジオテンシンII 2型受容体作動薬（ATRAG）C21の非盲検単群36週間第2a相試験AIRの中間解析

23/11/16

An update on emerging drugs for the treatment of idiopathic pulmonary fibrosis: a look towards 2023 and beyond

C Sofia, A Comes, G Sgalla, L Richeldi - Expert Opinion on Emerging Drugs, 2023

… Currently approved drug treatments for idiopathic pulmonary fibrosis (IPF), pirfenidone and nintedanib, have been shown to slow lung function decline and improve clinical outcomes. Since significant advances in the understanding of …

特発性肺線維症治療用の新薬に関する最新情報: 2023 年以降に向けた展望

[PDF] Musculoskeletal Comorbidities Predict Lung Function and Mortality in Patients with Idiopathic Pulmonary Fibrosis

M Sridhar, S Bodduluri, L O'Hare, S Blumhoff… - 2023

… Idiopathic pulmonary brosis (IPF) is a progressive disease associated with high mortality. Low muscle mass, frailty and sarcopenia lead to … and exercise tolerance and survival in patients with IPF. In this study, 70 patients with IPF underwent …

筋骨格系の併存疾患は特発性肺線維症患者の肺機能と死亡率を予測する

Salvianolic acid B protects against pulmonary fibrosis by attenuating stimulating protein 1‐mediated macrophage and alveolar type 2 cell senescence

Y Li, R Chen, J Wu, X Xue, T Liu, G Peng, R Wu… - Phytotherapy Research, 2023

… Idiopathic pulmonary fibrosis (IPF), as the most common idiopathic interstitial pneumonia, is caused by … IPF, we found that SAB alleviated the progression of pulmonary fibrosisin mice and reduced the accumulation of senescence …

サルビアノール酸 B は、刺激タンパク質 1 媒介マクロファージおよび肺胞 2 型細胞の老化を軽減することにより肺線維症を防ぐ

[HTML] The Role of Small Airway Disease in Pulmonary Fibrotic Diseases

GI Barkas, Z Daniil, OS Kotsiou - Journal of Personalized Medicine, 2023

… SAD and pulmonary fibrosis, urging further … Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease that primarily affects older adults. It is characterized by the progressive worsening of dyspnea and lung function, leading to respiratory failure …

肺線維性疾患における小気道疾患の役割

Bronchial epithelial and airway smooth muscle cell interactions in health and disease

R Abohalaka

… Chronic pulmonary diseases such as asthma, COPD, and Idiopathic pulmonary fibrosis are significant causes of mortality and morbidity worldwide. Currently, there is no radical treatment for many chronic pulmonary diseases, and the treatment …

健康と病気における気管支上皮と気道平滑筋細胞の相互作用

23/11/14

Homeostatic chemokines as putative therapeutic targets in idiopathic pulmonary fibrosis

RC Russo, VFJ Quesniaux, B Ryffel - Trends in Immunology, 2023

… Idiopathic pulmonary fibrosis (IPF) is a fatal chronic interstitial lung disease (ILD) that affects lung mechanical functions and gas exchange. IPF … Identifying an effective therapy for IPFremains a clinical challenge. Chemokines are key proteins …

特発性肺線維症の推定治療標的としての恒常性ケモカイン

[HTML] Idiopathic pulmonary fibrosis: Pathophysiology, cellular signaling, diagnostic and therapeutic approaches

I Shakeel, M Afzal, A Islam, SS Sohal, MI Hassan - Medicine in Drug Discovery, 2023

… Idiopathic pulmonary fibrosis (IPF) is a life-threatening and progressive interstitial lung disease. … IPF is associated with dyspnoea and cough, eventually impairing the quality of a large … Idiopathic pulmonary fibrosis (IPF) is progressive interstitial …

特発性肺線維症：病態生理学、細胞シグナル伝達、診断および治療アプローチ

[HTML] The Role of Immune Cells in the Pathogenesis of Idiopathic Pulmonary Fibrosis

Y Xu, P Lan, T Wang - Medicina, 2023

… Idiopathic pulmonary fibrosis (IPF) is a devastating disease of unknown etiology with limited treatment options. The role of the immune system in IPF has received increasing attention. Uncontrolled immune responses drive the onset and …

特発性肺線維症の発症における免疫細胞の役割

[PDF] Idiopathic pulmonary fibrosis: Addressing the current and future therapeutic advances along with the role of Sotatercept in the management of pulmonary hypertension

DD Hadi, MDM Marsool, ADM Marsool, N Vora… - Immunity, Inflammation and …, 2023

… A recent understanding of idiopathicpulmonary fibrosis (IPF) states that IPF is a progressive disease of the lung interstitium mainly … The precise causes of histopathological changes in IPF remain unknown. IPF is associated with various …

特発性肺線維症：肺高血圧症の管理におけるソタターセプトの役割とともに、現在および将来の治療の進歩に取り組む

S8 The burden of comorbidity in idiopathic pulmonary fibrosis versus chronic obstructive pulmonary disease

R Chapman, B Ozaltin, K Direk, J Jacob - 2023

… Aim To delineate comorbidities occurring in patients prior to their diagnosis of idiopathicpulmonary fibrosis (IPF). Comorbidity prevalence … trols without COPD or IPF. The impact of comorbidities on survival was then examined in the three study …

特発性肺線維症と慢性閉塞性肺疾患における併存疾患の負担

P222 The impact of cough and dyspnoea on anxiety and depression in idiopathic pulmonary fibrosis

R Islam, Z Wu, DJF Smith, TM Maher, JA Smith… - 2023

… Introduction and Objectives As cough remains a challenging symptom of IPF and other ILDs, we aimed to provide the first systematic synthesis of … Observational and interventional studies reporting cough-related measures in IPF and other ILDs …

特発性肺線維症における不安とうつ病に対する咳と呼吸困難の影響

P192 Assessing causal relationships between type 2 diabetes and idiopathic pulmonary fibrosis

S Moss, I Stewart, C Minelli, OC Leavy, RJ Allen… - 2023

… and Objective Idiopathic pulmonary fibrosis(IPF) is a chronic interstitial lung disease characterised by progressive lung fibrosis. Recent studies support the role of infection in IPF… Here we aimed to explore the specific link between HLA genetic …

2 型糖尿病と特発性肺線維症との因果関係の評価

P189 Genetic differences between sexes in idiopathic pulmonary fibrosis: a genome-wide SNP-by-sex interaction analysis

OC Leavy, AF Goemans, A Stockwell, RJ Allen… - 2023

… With IPF being observed in more males than females, we hypothesised that there may be different biological mechanisms modifying IPF … Method We performed a genome-wide SNP-by-sex interaction meta-analysis of IPF risk using six …