ChatGPTを活用して業務のAI化を進めています。プロンプトエンジニアリングの専門家です！と、名乗れるレベルではありませんが、かなり色々使いこなしてきています。この１年、病気で失われた能力は、別な能力を発達させる、進化することで生き残っていこうと思います。
<><><>
23/12/02
[HTML] Induced pluripotent stem cells modulate the Wnt pathway in the bleomycin-induced model of idiopathic pulmonary fibrosis
P Bayati, M Taherian, M Soleimani, H Farajifard… - Stem Cell Research & …, 2023
… cells (IPS) in modulating the expression of the cardinal genes of the Wnt pathway in a mouse model of idiopathic pulmonary fibrosis (IPF). … In the current study, we established a mouse model of idiopathic pulmonary fibrosis (IPF) by intratracheal …
- 人工多能性幹細胞は、ブレオマイシン誘発性の特発性肺線維症モデルにおいて Wnt 経路を調節する
[HTML] Mendelian randomization reveals no correlations between herpesvirus infection and idiopathic pulmonary fibrosis
H Yan, C Zhu, X Jin, G Feng - Plos one, 2023
… of herpesvirus significantly increases the risk of idiopathic pulmonary fibrosis (IPF), but it is unclear whether this effect is causal. We conducted a two-sample Mendelian randomization (MR) study to evaluate the causal relationship between three …
- メンデルランダム化により、ヘルペスウイルス感染と特発性肺線維症の間に相関関係がないことが判明
[PDF] Itaconate as a key regulator of respiratory disease
C Michalaki, GJ Albers, AJ Byrne - Clinical and Experimental Immunology, 2023
… for lung diseases such as asthma, idiopathicpulmonary fibrosis (IPF), and respiratory infections. This review aims to bring together evidence which highlights a role for itaconate in chronic lung diseases (such as asthma and pulmonary fibrosis) …
- 呼吸器疾患の主要な制御因子としてのイタコン酸
Nintedanib solid lipid nanoparticles improve oral bioavailability and ameliorate pulmonary fibrosis in vitro and in vivo models
R Kaur, TB Shaikh, HP Sripadi, M Kuncha… - International Journal of …, 2023
… Nintedanib (NIN) and pirfenidone are the only approved drugs for the treatment of IdiopathicPulmonary Fibrosis (IPF). However, NIN and pirfenidone have low oral bioavailability and limited therapeutic potential, requiring higher dosages to …
Progressive pulmonary fibrosis associated autoimmune diseases: Systematic review of the literature
LJC Santana, DRG Calderón, MR Rivera, JA Yate… - Revista Colombiana de …, 2023
… Patients with progressive pulmonary fibrosishad a similar 3.7-year median survival as those with idiopathic pulmonary fibrosis. Mortality was markedly increased (hazards ratio 3.29; 95% CI 2.76–3.82). A progressive course was seen in …
- 進行性肺線維症に関連する自己免疫疾患: 文献の系統的レビュー
GOLM1 Promotes Pulmonary Fibrosis through Upregulation of NEAT1
Y Wang, D Hu, L Wan, S Yang, S Liu, Z Wang, J Li, J Li… - American Journal of …, 2023
… Pulmonary fibrosis is a group of heterogeneous diseases characterized by diffuse fibrotic changes in the lung. Idiopathicpulmonary fibrosis (IPF) and other fibrotic lung diseases have poor prognosis with few antifibrotic drugs available (1, 2) …
- GOLM1 は NEAT1 の上方制御を通じて肺線維症を促進する
[PDF] Inhibition of Galectin-1 attenuates lung fibroblast activation and proliferation in lung fibrosis
J Xue, S Li - Cellular and Molecular Biology, 2023
… The purpose of this study was to investigate the parenchymal changes in idiopathicpulmonary fibrosis (IPF) caused by massive … -1 plays a critical role in IPF. In the current study, we aimed to identify Gal-1 as a crucial fibrotic protein in IPF …
- ガレクチン-1の阻害は肺線維症における肺線維芽細胞の活性化と増殖を減弱させる
Prevalence and Spectrum of Autoimmune Diseases Among Patients with Telomere Biology Disorder
AM Kelly, LG Banaszak, K Smith-Simmer, K Shoger… - Blood, 2023
… Disease phenotypes are variable including bone marrow failure, immunodeficiency, myelodysplastic syndrome (MDS), acute myeloid leukemia (AML), idiopathic pulmonary fibrosis(IPF), liver cirrhosis, nail dystrophy, and premature …
- テロメア生物学的障害患者における自己免疫疾患の有病率と範囲
23/11/30
[HTML] Spatially distinct molecular patterns of gene expression in idiopathic pulmonary fibrosis
RZ Blumhagen, JS Kurche, CD Cool, AD Walts… - Respiratory Research, 2023
… Among the 19 IPF cell types that were observed with the IPF reference, we observed fewer ciliated cells (p = 0.007) and greater pericytes (p = 7 × 10 −5 ) between IPF and controls with histologically normal lung tissue in the normal …
- 特発性肺線維症における空間的に異なる遺伝子発現の分子パターン
MMP19 Variants in Familial and Sporadic Idiopathic Pulmonary Fibrosis
Y Fan, C Zheng, R Ma, J Wang, S Yang, Q Ye - Lung, 2023
… Gene variants have been identified in patients with familial or sporadic idiopathic pulmonaryfibrosis (IPF). These variants may partially account for the genetic risk of IPF. The aim of this study was to identify potential genes involved in both familial and …
- 家族性および散発性特発性肺線維症におけるMMP19変異体
Inhaled pulmonary surfactant biomimetic liposomes for reversing idiopathic pulmonary fibrosis through synergistic therapeutic strategy
B Wang, Y Gao, M Xue, M Wang, Z Zhang, L Zhang… - Biomaterials, 2023
… Idiopathic pulmonary fibrosis (IPF) stands as a highly heterogeneous and deadly lung disease, yet the available treatment options remain limited. Combining myofibroblast inhibition with ROS modulation in damaged AECs offers a …
- 相乗的な治療戦略を通じて特発性肺線維症を逆転させるための吸入肺サーファクタント生体模倣リポソーム
Harnessing the Translational Power of Bleomycin Model: New Insights to Guide Drug Discovery for Idiopathic Pulmonary Fibrosis
A Murgo, F Bignami, G Federico, G Villetti, M Civelli… - Frontiers in Pharmacology
… Despite the wide variety of different in vivo models for IPF, these preclinical models have shown limitations that may significantly impair … )-induced pulmonary fibrosis mouse model, introducing and validating novel readouts to evaluate the …
- ブレオマイシン モデルのトランスレーショナル パワーの活用: 特発性肺線維症の創薬を導く新たな洞察
[PDF] Assessment of causal associations among gut microbes, plasma metabolites and idiopathic pulmonary fibrosis: a bidirectional Mendelian randomization study
W Du, X wei Wu, J Wu, B yu Zhang, L sheng Chen, X Yi - 2023
… is known as idiopathic pulmonary fibrosis. A growing body of research indicates that the causes of idiopathic pulmonary fibrosis may include … However, uncertainty exists regarding the causative link between idiopathicpulmonary fibrosis, plasma …
Identifying the Link between Serum VEGF and KL-6 Concentrations: A Correlation Analysis for Idiopathic pulmonary fibrosis interstitial lung disease Progression
S Luo - Frontiers in Medicine
… IPF-ILD. Specifically, it assessed their correlation with PaO2, a measure of pulmonary gas function, to provide diagnostic and prognostic indicators. Methods: Patients with IPF-… serum marker KL-6 and the degree of fibrotic damage in IPF-ILD …
- 血清VEGFとKL-6濃度の間の関連性の特定：特発性肺線維症と間質性肺疾患の進行に関する相関分析
Inhalation Lenalidomide-Loaded Liposome for Bleomycin-Induced Pulmonary Fibrosis Improvement
Z Luo, L Ji, H Liu, Y Sun, C Zhao, X Xu, X Gu, X Ai… - AAPS PharmSciTech, 2023
… Idiopathic pulmonary fibrosis (IPF) is a progressive, fibrotic interstitial lung disease with … The effectiveness of lenalidomide (Len) liposomal lung delivery in idiopathic pulmonaryfibrosis was … Inhalation Len-Lip provided a reference for the …
- ブレオマイシン誘発性肺線維症改善のための吸入レナリドマイド充填リポソーム
[HTML] ACSS3 regulates the metabolic homeostasis of epithelial cells and alleviates pulmonary fibrosis
L Wang, H Yuan, W Li, P Yan, M Zhao, Z Li, H Zhao… - Biochimica et Biophysica …, 2024
… Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease of unknown etiology. The emerging evidence demonstrates that metabolic homeostatic imbalance caused by repetitive injuries of the alveolar epithelium is the …
- ACSS3は上皮細胞の代謝恒常性を調節し、肺線維症を軽減
[PDF] Cellular and molecular mechanisms of fibrosis and resolution in bleomycin-induced pulmonary fibrosis mouse model revealed by spatial transcriptome analysis
Q Li, Y Wang, L Ji, J He, H Liu, W Xue, H Yue, R Dong… - Heliyon
… essential process of pulmonary fibrosis and, more importantly, prove its efficiency as an IPFmodel. Studies focusing on familial pulmonaryfibrosis or genome-wide association studies have identified genetic factors related to idiopathic pulmonary …
- 空間トランスクリプトーム解析により明らかになったブレオマイシン誘発性肺線維症マウスモデルにおける線維症と回復の細胞および分子機構
[HTML] Derivation and validation of a non-invasive prediction tool to identify pulmonary hypertension in patients with IPF: evolution of the model FORD
SD Nathan, A Chandel, Y Wang, J Xu, L Shao… - The Journal of Heart and …, 2023
… The administration of inhaled prostanoids to patients with pulmonary hypertension (PH) related to idiopathic pulmonary fibrosis (IPF) and other fibrotic interstitial lung diseases improves functional outcomes. Selection of patients with …
- IPF患者の肺高血圧症を特定するための非侵襲的予測ツールの導出と検証：モデルFORDの進化
23/11/28
[HTML] Ectopic and visceral fat deposition in aging, obesity, and idiopathic pulmonary fibrosis: an interconnected role
X Cheng, S Jiang, B Pan, W Xie, J Meng - Lipids in Health and Disease, 2023
… lipid metabolism-related genes (LMRGs) associated with pulmonary fibrosis, introduces IPF assessment tools that are easily applicable in clinical practice, and offers novel intervention approaches from a new perspective to improve fat …
- 老化、肥満、特発性肺線維症における異所性および内臓脂肪の沈着：相互に関連した役割
[HTML] Immune mechanisms and novel therapies for idiopathic pulmonary fibrosis
D Gao, W Gao, W Zhu, Z Zhai - Pharmaceutical Science Advances, 2023
… Idiopathic pulmonary fibrosis (IPF), a progressive lung disease characterized by irreversible lung … pulmonary fibrosis and the emerging drugs targeting the immune system in recent years, aiming to provide insights into the mechanism and treatment …
- 特発性肺線維症の免疫機構と新規治療法
[PDF] Integrated bioinformatics analysis screened the key genes and pathways of idiopathic pulmonary fibrosis
J Wu, Y Wei, H Kang, X Yu, S Wei, T Xue, X Kong - 2023
… has been identi ed as a driver of IPF, so we further analyzed the immune environment in IPF. We use the ESTIMATE algorithm to calculate the immune-related scores in the IPF and control groups. As shown in Fig 6, stromal score, immune …
- 統合バイオインフォマティクス分析により、特発性肺線維症の主要な遺伝子と経路をスクリーニング
[PDF] Role of Telomere Length in Survival of Patients with Idiopathic Pulmonary Fibrosis and Other Interstitial Lung Diseases
S Tesolato, J Vicente-Valor, JR Jarabo, J Calatayud… - 2023
… cysts or airspace filling, sarcoidosis, orphan diseases and idiopathic ILDs (from which the most common is the idiopathic pulmonaryfibrosis [IPF]) [3,4]. IPF is a progressive-fibrosing ILD with the radiological and/or histological pattern of usual …
- 特発性肺線維症およびその他の間質性肺疾患患者の生存におけるテロメア長の役割
[HTML] Animal models of acute exacerbation of pulmonary fibrosis
X Ye, M Zhang, H Gu, M Liu, Y Zhao, Y Shi, S Wu… - Respiratory Research, 2023
… Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive scarring interstitial lung disease with an unknown cause. Some patients may experience acute exacerbations (AE), which result in severe lung damage visible on imaging or …
- 肺線維症の急性増悪の動物モデル
[HTML] The keratin-desmosome scaffold of internal epithelia in health and disease–The plot is thickening
DM Toivola, L Polari, T Schwerd, N Schlegel, P Strnad - Current Opinion in Cell …, 2024
… DSP has been identified to be expressed not only in airway bronchial epithelial cells but also in alveolar type 1 and 2 cells [21], which are thought to be the main cells affected in idiopathic pulmonary fibrosis (IPF). A non-coding DSP rs2076295 G-allele …
- 健康と病気における内部上皮のケラチン - デスモソーム足場 – プロットは厚くなっています
Pulmonary fibrosis: Emerging diagnostic and therapeutic strategies
B Selvarajah, M Platé, RC Chambers - Molecular Aspects of Medicine, 2023
… Idiopathic pulmonary fibrosis (IPF) represents the most rapidly progressive and lethal of all fibrotic diseases with a dismal median survival of 3.5 years from diagnosis. Although the approval of the antifibrotic agents, pirfenidone and …
- 肺線維症：新たな診断および治療戦略
Human pluripotent stem cell-derived alveolar organoids: Cellular heterogeneity and maturity.
JH Jung, SR Yang, WJ Kim, CK Rhee, SH Hong - Tuberculosis and Respiratory …, 2023
… Chronic respiratory diseases such as idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, and respiratory infections injure the alveoli; the damage evoked is mostly irreversible and occasionally leads to death. Achieving a …
- ヒト多能性幹細胞由来の肺胞オルガノイド: 細胞の不均一性と成熟度。
[PDF] Lung Transplantation is a Therapeutic Choice for Patients with Respiratory Insufficiency
S Franjic - 2023
… The mortality rate is higher in patients with primary pulmonary hypertension, idiopathicpulmonary fibrosis, or sarcoidosis, and lower in those with COPD or α1-antitrypsin deficiency. Mortality is higher when transplanting one lung wing than both lungs …
- 肺移植は呼吸不全患者にとっての治療上の選択です
<><><>
特発性肺線維症( idiopathic pulmonary fibrosis (IPF) )関連の学術的情報収集してシェアしています。Google Scholar SearchのUpdateを定期的に掲載しています。GoogleのAIが一定の重み付けはしているとは思いますが、玉石混交です。
当面、毎週アラートの内容をアップしていこうと思います。
###
