ChatGPTを活用して業務のAI化を進めています。プロンプトエンジニアリングの専門家です！と、名乗れるレベルではありませんが、かなり色々使いこなしてきています。この１年、病気で失われた能力は、別な能力を発達させる、進化することで生き残っていこうと思います。
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23/09/30
[PDF] Efficacy of Pirfenidone According to Dose in Patients with Idiopathic Pulmonary Fibrosis: A Prospective, Observational, Single-Center Cohort Study
HY Lee, SY Jung, JH Jang, J Ko, DW Kim, M Her… - 2023
… Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with a poor prognosis. Pirfenidone is approved and widely used for the treatment of IPF … for the prevention of disease progression in patients with IPF. Methods: This was a …
- 特発性肺線維症患者における用量に応じたピルフェニドンの有効性:前向き観察的単一施設コホート研究
[PDF] Externalized histones fuel pulmonary fibrosis via a platelet-macrophage circuit of TGFβ1 and IL-27
DR Riehl, A Sharma, J Roewe, F Murke, C Ruppert… - Proceedings of the National …, 2023
… within the immunologic networks of pulmonary fibrosis, we studied externalized histones in … in cell-free BAL fluids of patients with idiopathic pulmonary fibrosis (IPF; n = 29) as compared to … to neutralizing antibodies for improving the severity of …
- 外在化したヒストンは、TGFβ1とIL-27の血小板マクロファージ回路を介して肺線維症を促進する
P26 Felty's syndrome as the first presentation of rheumatoid arthritis
F Salih, W Gunasekera - Rheumatology Advances in Practice, 2023
Introduction Felty's syndrome (FS) is a rare, autoimmune disease occurring in < 1% of patients with rheumatoid arthritis (RA) and comprising a triad of persistent idiopathicneutropenia, splenomegaly and RA. In some affected individuals, FS may …
- 関節リウマチの最初の症状としてのフェルティ症候群
23/09/28
The impact of nintedanib and pirfenidone on lung function and survival in patients with idiopathic pulmonary fibrosis in real-life setting
G Santos, A Fabiano, PC Mota, I Rodrigues… - Pulmonary Pharmacology & …, 2023
Background Idiopathic pulmonary fibrosis(IPF) is a chronic, fibrosing interstitial pneumonia of unknown cause that is associated with radiological and/or histological features of usual interstitial pneumonia (UIP). A mean survival of 2–5 years was …
- 実際の環境における特発性肺線維症患者の肺機能と生存に対するニンテダニブとピルフェニドンの影響
Interplay between system xc-and glutaredoxin; relevance for idiopathic pulmonary fibrosis
M Raina - 2023
… Idiopathic pulmonary fibrosis (IPF) is characterized by massive deposition of extracellular matrix in the lung interstitium leading to impaired … to the development of IPF. Out of the main profibrotic molecular mechanisms that contribute to IPF …
- システム xc- とグルタレドキシンの間の相互作用。 特発性肺線維症との関連性
[PDF] NHLRC2 AND EXTRACELLULAR MATRIX PROTEINS IN IDIOPATHIC PULMONARY FIBROSIS AND LUNG CANCER
M Kreus
Idiopathic pulmonary fibrosis (IPF) and lung cancer share poor prognosis, similar genetic and epigenetic alterations, and common risk factors such as smoking. Myofibroblasts, which are often referred to as cancer-associated fibroblasts in tumors …
- 特発性肺線維症および肺がんにおけるNHLRC2および細胞外マトリックスタンパク質
Idiopathic Interstitial Pneumonias
S Argun Barış, I Başyiğit, SD Nathan - Airway diseases, 2023
… In this report, AE-IPF was defined as acute and clinically significant deterioration in patients with IPF without any underlying cause. The … “idiopathic” was removed from the definition, and both idiopathic and triggered exacerbations were included in …
- 特発性間質性肺炎
Evaluating Tissue Heterogeneity in the Radiologically Normal-Appearing Tissue in IPF Compared to Healthy Controls
J John, AR Clark, H Kumar, KS Burrowes, AC Vandal… - Academic Radiology, 2023
… Idiopathic Pulmonary Fibrosis (IPF) is a progressive interstitial lung disease characterised by heterogeneously distributed fibrotic lesions. The inter- and intra-patient heterogeneity of the disease has meant that useful biomarkers of severity and …
- 健康な対照と比較した、IPF における放射線学的に正常に見える組織における組織の不均一性の評価
Effect of Mycetoma in Lung Transplant Patients–a Single Center Experience
S Singh, J Lum, A Majeed - Transplantation Proceedings, 2023
… In the post-transplant group, all patients who had mycetoma were diagnosed with idiopathicpulmonary fibrosis before transplant, and it is unclear if the underlying pathology of fibrosis put them at a higher risk of mycetoma formation and its …
- 肺移植患者におけるマイセトーマの影響 – 単一センターでの経験
[PDF] ICU Management of the Patient with Fibrotic Interstitial Lung Disease
A Krishnan, DR Janz, MR Lammi - CHEST Critical Care, 2023
… Clinical course and prognosis in survivors of acute exacerbations of idiopathic pulmonaryfibrosis. Respir Investig. 2021;59(4):408-413. … Acute exacerbations of idiopathic pulmonaryfibrosis and the role of corticosteroids. Breathe (Sheff). 2020;16(3):200086. …
- 線維性間質性肺疾患患者の ICU 管理
[PDF] The causality between telomere length and chronic lung diseases: A Bidirectional Mendelian Randomization Analysis
Y Zhan, Y Gu, R Yang, Z Deng, S Chen, Q Huang, J Wu… - 2023
… , including chronic obstructive pulmonary disease (COPD), idiopathic pulmonary brosis (IPF), asthma, bronchiectasis and pulmonary arterial … Plenteous researches supported the correlations between TL and other lung diseases to some extent …
- テロメア長と慢性肺疾患との因果関係: 双方向メンデルランダム化分析
[PDF] Prognostic impact of HNF4α expression in interstitial lung disease
澤住知枝
… [材料と方法] 2008 年 1 月から 2019 年 5 月までに,神奈川県立循環器呼吸器 病 センターにおいて,胸腔鏡下に生検された間質性肺疾患患者 309 例(Idiopathic pulmonary fibrosis; IPF 61 例,non-IPF173 例,unclassifiable ILD75 名)の肺生検標本を収集した.組 …
- 間質性肺疾患における HNF4α 発現の予後への影響
[PDF] Interstitial Lung Diseases and COVID19 Pneumonia
RS Mahla - 2023
… This study is commendable for its case definition and subgroup stratification within interstitial lung diseases (ILDs), where idiopathic pulmonary fibrosis (IPF), interstitial pneumonia with autoimmune features (IPAF), and connective tissue …
23/09/26
[HTML] IL18R1-Related Molecules as Biomarkers for Asthma Severity and Prognostic Markers for Idiopathic Pulmonary Fibrosis
K Lin, T Wang, Q Tang, T Chen, M Lin, J Jin, J Cao… - Journal of Proteome …, 2023
… the role of IL18R1 and related genes in asthma and idiopathic pulmonary fibrosis(IPF). Olink identified 52 differentially expressed proteins in … IL18R1-related molecules may serve as biomarkers for monitoring uncontrolled or severe asthma and as …
- 喘息重症度のバイオマーカーおよび特発性肺線維症の予後マーカーとしての IL18R1 関連分子
Cardiopulmonary Exercise Testing Differentiates Disease Progression in Monozygotic Twins With Idiopathic Pulmonary Fibrosis
OW Tomlinson, A Duckworth, RL Wollerton, CJ Scotton… - Journal of Clinical Exercise …, 2023
… routine clinical evaluation and management of IPF can yield information that cannot be … IPF. The use of serial CPET illustrated in this study aids in improving the ability to identify possible actionable non-IPF specific contributing causes of …
- 心肺運動テストは特発性肺線維症の一卵性双生児の疾患進行を区別する
A Phase I Study of TRK-250, a Novel siRNA-Based Oligonucleotide, in Patients with Idiopathic Pulmonary Fibrosis
H Doi, J Atsumi, D Baratz, Y Miyamoto - Journal of Aerosol Medicine and Pulmonary …, 2023
… to prevent the progression of pulmonaryfibrosis. Herein, a phase I study was conducted to investigate the safety and pharmacokinetics (PKs) of TRK-250 in patients with idiopathicpulmonary fibrosis (IPF). Method: In the phase I study, 34 IPF …
- 特発性肺線維症患者を対象とした新規siRNAベースのオリゴヌクレオチドTRK-250の第I相試験
Elastic Registration Algorithm Based on Three-dimensional Pulmonary MRI in Quantitative Assessment of Severity of Idiopathic Pulmonary Fibrosis.
X Yang, P Yu, W Xu, H Sun, J Duan, Y Han, L Zhu… - Journal of Thoracic Imaging, 2023
… in idiopathic pulmonary fibrosis (IPF) using elastic registration based on 3-dimensional pulmonary magnetic resonance imaging (3D-PMRI) and to assess its' correlations with the severity of IPF … Lung elasticity decreased in IPF patients and correlated …
[HTML] SRC and TKS5 mediated podosome formation in fibroblasts promotes extracellular matrix invasion and pulmonary fibrosis
I Barbayianni, P Kanellopoulou, D Fanidis, D Nastos… - Nature Communications, 2023
… , is a pathogenic hallmark of IdiopathicPulmonary Fibrosis, a lethal and incurable disease. In this report, increased expression of TKS5, a scaffold protein essential for the formation of podosomes, was detected in the lung tissue of Idiopathic Pulmonary …
- 線維芽細胞におけるSRCおよびTKS5媒介ポドソーム形成は細胞外マトリックス浸潤と肺線維症を促進する
[PDF] E-Selectin, ICAM-1, and ET-1 biomarkers address the concern of the challenging diagnosis of interstitial lung disease in patients with autoimmune diseases
S Remuzgo-Martínez, F Genre, F Genre… - 2023
… Additionally, the diagnosis complexity of AD-ILD+ increases due to the similarity of clinical, pathological, and epidemiological features with idiopathic pulmonary fibrosis (IPF) [7–9]. Of note, many studies of biomarkers for the risk of developing ILD …
- E-セレクチン、ICAM-1、ET-1 バイオマーカーは、自己免疫疾患患者の間質性肺疾患の診断が難しいという懸念に対処します
IgG78-DM1 inhibits pulmonary fibrosis by targeting and killing CD248-positive myofibroblasts in mice
J Wang, M Wei, Z Li, Y Zhou, D Han - Xi bao yu fen zi Mian yi xue za zhi= Chinese …, 2023
… , idiopathic pulmonary fibrosis group, human IgG-DM1 (hIgG-DM1) control group, and IgG78-DM1 treatment group. Then, the mouse models with pulmonary fibrosis … Sirius Red staining to evaluate the degree of pulmonaryfibrosis. Real-time …
- IgG78-DM1 はマウスの CD248 陽性筋線維芽細胞を標的にして殺すことにより肺線維症を抑制します
Lung Magnetic Resonance Imaging for Prediction of Progression in Patients With Nonidiopathic Pulmonary Fibrosis Interstitial Lung Disease: A Pilot Study.
CA Ruano, MF Moraes-Fontes, A Borba, M Grafino… - Journal of Thoracic Imaging, 2023
… Prospective observational cohort study, in which patients with non-idiopathic pulmonaryfibrosis ILD underwent MRI at baseline (1.5 T). T2-weighted images (T2-WI) were acquired by axial free-breathing respiratory-gated fat-suppressed "periodically …
- 非特発性肺線維症間質性肺疾患患者の進行予測のための肺磁気共鳴画像法:パイロット研究。
A novel BRD4 degrader, ARV-825, attenuates lung fibrosis through senolysis and antifibrotic effect
S Sato, K Koyama, H Ogawa, K Murakami, T Imakura… - Respiratory Investigation, 2023
… Recent studies suggest that cellular senescence is related to the pathogenesis of idiopathic pulmonary fibrosis. However, cellular senescence has yet to be targeted therapeutically in clinical practice. ARV825, a recently developed BRD4 degrader …
- 新規の BRD4 分解剤 ARV-825 は老化細胞溶解と抗線維化効果により肺線維症を軽減します
Angiotensin-converting enzyme 1 gene polymorphisms in patients with systemic sclerosis-associated interstitial lung disease: a single centre retrospective …
B Karanović, M Barešić, A Merkler Šorgić, B Anić - Rheumatology International, 2023
… Angiotensin-converting enzyme (ACE) 1 gene polymorphisms have been associated with vascular permeability, alveolar endothelial dysfunction and fibroblast proliferation and have been studied in pulmonary diseases such as COPD …
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特発性肺線維症( idiopathic pulmonary fibrosis (IPF) )関連の学術的情報収集してシェアしています。Google Scholar SearchのUpdateを定期的に掲載しています。GoogleのAIが一定の重み付けはしているとは思いますが、玉石混交です。
当面、毎週アラートの内容をアップしていこうと思います。
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