IPF Weekly Update - AIとIPFと癒しの音楽

ChatGPTを活用して業務のAI化を進めています。プロンプトエンジニアリングの専門家です！と、名乗れるレベルではありませんが、かなり色々使いこなしてきています。この１年、病気で失われた能力は、別な能力を発達させる、進化することで生き残っていこうと思います。

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23/07/29

Measure of lung dielectric proprieties in patients with idiopathic pulmonary fibrosis: Correlation with clinical, radiological and pulmonary functional parameters

F Patrucco, C Albera, M Bellan, M Zava, F Gavelli… - Respiratory Medicine, 2023

… reliability of ReDS™ measure in IdiopathicPulmonary Fibrosis (IPF) patients and in healthy … Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pneumonia and at histopathologic examination presents features of usual …

特発性肺線維症患者における肺の誘電特性の測定：臨床的、放射線学的、および肺機能パラメータとの相関

Managing Chronic Cough Associated with Idiopathic Pulmonary Fibrosis—Will Nalbuphine Fill an Unmet Need?

RS Irwin, JM Madison - NEJM Evidence, 2023

… , with placebo in a cohort of patients with definite or probable idiopathic pulmonaryfibrosis (IPF). In this small, short-term trial of 38 … Are the data from this opioid agonist–antagonist trial promising enough to justify future trials in patients …

特発性肺線維症に伴う慢性咳の管理 - ナルブフィンは満たされていないニーズを満たすことができるか？

[PDF] Establishment and Application of the BRP Prognosis Model for Idiopathic Pulmonary Fibrosis

X Cheng, Z Feng, B Pan, Q Liu, Y Han, L Zou, P Rong… - 2023

… Idiopathic pulmonary brosis (IPF) is the most common idiopathic interstitial lung disease, with … Idiopathic pulmonary brosis (IPF) is a progressive and destructive fatal lung disease. There are over ve million IPF patients worldwide, and both the …

特発性肺線維症のBRP予後モデルの確立と応用

[HTML] Mesenchymal Stem Cells Inhibit Epithelial-to-Mesenchymal Transition by Modulating the IRE1α Branch of the Endoplasmic Reticulum Stress Response

R Luo, Y Wei, P Chen, J Zhang, L Wang, W Wang… - Stem Cells International, 2023

… Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial lung disease, … Epithelial-mesenchymal transition (EMT) plays a key role in IPF pathogenesis. Endoplasmic … Idiopathic pulmonary fibrosis(IPF) is the most …

間葉系幹細胞は、小胞体ストレス応答のIRE1α分岐を調節することによって上皮から間葉への移行を阻害する

D Franco-Palacios, L Allenspach, L Stagner, K Bryce… - OBM Transplantation, 2023

… For pulmonary fibrosis with exacerbation or rapid progression after COVID-19, our approach was in line with those under lung transplant evaluation for idiopathic pulmonary fibrosis(IPF), following the International Society for Heart and Lung …

新型コロナウイルス感染症関連肺疾患に対する肺移植：プログラムされた中型肺移植の結果に関する追跡調査

[PDF] The interplay of physical and cognitive function in rehabilitation of interstitial lung disease patients: a narrative review

M Hanada, T Tanaka, R Kozu, Y Ishimatsu… - 2023

… Although 60% to 70% of idiopathicpulmonary fibrosis (IPF) patients die as a consequence of an exacerbation, other causes of death … Distinct profile and prognostic impact of body composition changes in idiopathicpulmonary fibrosis and …

間質性肺疾患患者のリハビリテーションにおける身体機能と認知機能の相互作用：ナラティブレビュー

Pirfenidone in fibrotic hypersensitivity pneumonitis: is it ready for prime time?

D Assayag, N Chaudhuri - Thorax, 2023

… Its differentiation from idiopathic interstitial pneumonias can be problematic, but is important … in the diagnoses of HP compared with idiopathic pulmonary fibrosis (IPF).2 A consensus-… the use of antifibrotics in conditions other than IPF, including fHP …

線維性過敏性肺炎におけるピルフェニドン：ゴールデンタイムの準備はできているか？

23/07/27

Loss of ANT1 Increases Fibrosis and Epithelial Cell Senescence in Idiopathic Pulmonary Fibrosis

J Sui, JC Boatz, J Shi, Q Hu, X Li, Y Zhang… - American Journal of …, 2023

… We found SLC25A4 (ANT1) and SLC25A5 (ANT2) expression is reduced in the lungs of IPFpatients and particularly within alveolar type II … -induced mouse models of pulmonary fibrosis. In summary, loss of ANT1 contributes IPF …

ANT1の喪失により、特発性肺線維症の線維化と上皮細胞の老化が増加する

[PDF] Genetic variations in idiopathic pulmonary fibrosis and patient response to pirfenidone

A Kubbara, WH Amundson, A Herman, AM Lee… - Heliyon, 2023

… Gastro-oesophageal reflux and gastric aspiration in idiopathic pulmonary fibrosispatients. … The genetic basis of idiopathicpulmonary fibrosis. Eur Respir J 2015;45:1717–1727. doi:… TGF-β1 T869C polymorphism may affect susceptibility to idiopathic pulmonary …

特発性肺線維症の遺伝的変異とピルフェニドンに対する患者の反応

[HTML] Properties of Pleural Mesothelial Cells in Idiopathic Pulmonary Fibrosis and Cryptogenic Organizing Pneumonia

G Loloci, YM Kim, WI Choi, HJ Jang, SJ Park, KY Kwon - Journal of Korean Medical …, 2023

… Profibrotic properties of pleural mesothelial cells may play an important role in the fibrosis activity in idiopathic pulmonary fibrosis (IPF). The purpose of this study was to compare the expression of pleural mesothelial cell markers in IPF and cryptogenic …

特発性肺線維症および原因不明の器質性肺炎における胸膜中皮細胞の特性

Spatial Decoding of Immune Cell Contribution to Fibroblastic Foci in Idiopathic Pulmonary Fibrosis

DC Yang, SW Hsu, JM Li, J Oldham, CH Chen - American Journal of Respiratory and …, 2023

Methods and Results To investigate the role of immune cells in mediating fibrosis, we utilized biopsy samples obtained from IPF patients. We use a combination of histological staining and multiplex immunofluorescence to identify fibrotic lesions in …

特発性肺線維症における線維芽細胞巣への免疫細胞の寄与の空間解読

The aged extracellular matrix and the pro-fibrotic role of senescence-associated secretory phenotype (SASP)

YA Mebratu, S Soni, L Lorena Rosas, M Rojas… - American Journal of …, 2023

… Idiopathic pulmonary fibrosis (IPF) is an irreversible and fatal lung disease that is 32 primarily found in the elderly population, and several studies have demonstrated that 33 aging is the major risk factor for IPF… Idiopathicpulmonary fibrosis (IPF) is …

老化した細胞外マトリックスと老化関連分泌表現型（SASP）の線維化促進の役割

[PDF] Interstitial Lung Disease: Definitions and Classifications

DK Rai, VB Gupta

… In 2002, idiopathic pulmonary fibrosis (IPF) was defined as a type of chronic fibrosing interstitial pneumonia of unknown cause which is limited to the lungs. The diagnostic criteria varied depending on whether surgical lung biopsy was …

間質性肺疾患：定義と分類

[PDF] GPCRs and fibroblast heterogeneity in fibroblast‐associated diseases

NV Dwivedi, S Datta, K El‐Kersh, RT Sadikot, AK Ganti… - The FASEB Journal, 2023

… 3.1 | Idiopathic pulmonary fibrosisIdiopathic pulmonary fibrosis (IPF) is an advanced and chronic lung disease marked by uncontrolled fibrogenesis leading … Worsening pulmonary fibrosis eventually leads to respiratory distress and death …

線維芽細胞関連疾患におけるGPCRと線維芽細胞の不均一性

[HTML] Increased expiratory flows identify early interstitial lung disease

SM Alyami, O Moran-Mendoza - Annals of Thoracic Medicine, 2023

… Our study aimed to assess if high expiratory flows are the earliest PFT abnormality in patients with idiopathic pulmonary fibrosis (IPF) and … interstitial pneumonia and the most common idiopathic interstitial pneumonia.[ 3 ] Most ILDs …

呼気流量の増加により初期の間質性肺疾患が同定される

[HTML] Progressive fibrotic interstitial lung disease

CAC Pereira, S Cordero, AC Resende - 2023

… Differentiating IPF from non-IPF is particularly important because the prognosis of IPF is worse than that of other … IPF is the most common idiopathic fibrotic ILD, fibrosis in non-IPF ILDs is frequently preceded by or linked with inflammation. A …

進行性線維性間質性肺疾患

[PDF] Cubane and Cyclooctatetraene Pirfenidones–Synthesis and Biological evaluation

Y Liu, BJ Wen Liang, N Modhiran, GP Savage… - Asian Journal of Organic …, 2023

… Abstract: Pirfenidone, an oral anti-fibrotic and anti-inflammatory medication used for the treatment of idiopathic pulmonary fibrosis(IPF), has been proposed to treat postCOVID pneumonia pulmonary fibrosis (PF). However, pirfenidone displays side …

キュバンおよびシクロオクタテトラエンピルフェニドン - 合成および生物学的評価

23/07/25

[HTML] Nintedanib-Induced Gastric Antral Vascular Ectasia in Patients With Idiopathic Pulmonary Fibrosis

T Takahashi, Y Sato, T Kashihara, Y Miyata, Y Fujino… - ACG Case Reports Journal, 2023

… for the treatment of idiopathic pulmonaryfibrosis (IPF), which is a … of IPF is unknown, we cannot completely rule out the possibility that IPF is directly or indirectly involved in GAVE development. However, to the best of our knowledge …

特発性肺線維症患者におけるニンテダニブ誘発性胃前庭血管拡張症

Pulmonary Fibrosis and COVID-19

D Kramer, R Hilton, J Roman - The American Journal of the Medical Sciences, 2023

… Those with idiopathic pulmonary fibrosisfared particularly poorly with a HR of death of 1.74. Within these ILD patients, many additional features compounded risk for death, including male sex, baseline lung capacity, and etiology of ILD. Males with …

肺線維症と新型コロナウイルス感染症（COVID-19）

[PDF] Anti-inflammatory and Antifibrotic Potential of Longidaza in the Bleomycin-induced Pulmonary Fibrosis

A Pakhomova, O Pershina, P Bochkov, N Ermakova… - 2023

… Abstract: Idiopathic pulmonary fibrosis(IPF) is one of the most common forms of interstitial lung disease characterized by progressive parenchymal fibrosis and respiratory failure. In a model of bleomycin-induced pulmonary fibrosis, the …

ブレオマイシン誘発肺線維症におけるロンギダザの抗炎症および抗線維化の可能性

Reply: Confounding in Mendelian randomisation studies

CJ Reynolds, C Minelli - European Respiratory Journal, 2023

… -oesophageal reflux disease (GORD) on idiopathic pulmonary fibrosis (IPF) [1], as this gives … This is exactly why we chose to investigate whether GORD has a causal effect on IPF using … is present from birth and therefore not modified by …

返信：メンデルランダム化研究における交絡

[PDF] Expression profiles of nintedanib-targeting molecules in progressive fibrotic interstitial lung diseases (non-IPF-PF) and IPF

L Zhang, P Wang, Y Mo, Y Zhang, X Tong, X Zhang… - 2023

… Idiopathic pulmonary brosis (IPF) and other types of progressive brotic interstitial lung diseases (nonIPF-PF), such as chronic … aim to summarize the expression pro le of nintedanib in both IPF and nonIPF-PF, and validate the drug’s potential for …

進行性線維性間質性肺疾患（非IPF-PF）およびIPFにおけるニンテダニブ標的分子の発現プロファイル

[PDF] Current mechanisms in the pathogenesis of lung fibrosis

MMN Engin, Ö Özdemir - Trends in Immunotherapy, 2023

… Idiopathic Pulmonary Fibrosis (IPF) is the most mortal lung disease with overall 2–3 year … SASP contributes to cell proliferation, differentiation and idiopathic pulmonaryfibrosis … stress incompatible reactions, increasing sensitivity to injury …

肺線維症の発症における現在のメカニズム

[HTML] ANTI-VAXXERS AND THE COVID CRISIS: THE SORRY STORY OF THE PERNICIOUS INFLUENCE OF A PSEUDO-SCIENCE

M Ruse

… At once, a much more knowledgeable pulmonologist diagnosed my problem – idiopathic pulmonary fibrosis (IPF). She dashed off somewhere leaving me to read the posters on the wall, one of which breezily told me that people diagnosed with IPF …

反ワクチン主義者と新型コロナウイルス危機：疑似科学の有害な影響に関する悲しい話