ChatGPTを活用して業務のAI化を進めています。プロンプトエンジニアリングの専門家です！と、名乗れるレベルではありませんが、かなり色々使いこなしてきています。この１年、病気で失われた能力は、別な能力を発達させる、進化することで生き残っていこうと思います。
<><><>
<>
24/06/29
[HTML] Therapeutic potential of human stem cell-derived extracellular vesicles in idiopathic pulmonary fibrosis
KS Lee, SH Yeom, MK Kim, CH Woo, YC Choi, JS Choi… - Extracellular Vesicle, 2024
… Idiopathic pulmonary fibrosis (IPF) is a lethal and chronic lung disease that occurs due to persistent epithelial cell injury and abnormal extracellular matrix (ECM) deposition. Extracellular vesicles (EVs) have been proposed as a potential …
- 特発性肺線維症におけるヒト幹細胞由来細胞外小胞の治療可能性
[HTML] Integrated ML-Based Strategy Identifies Drug Repurposing for Idiopathic Pulmonary Fibrosis
F Ahmed, A Samantasinghar, MA Bae, KH Choi - ACS Omega, 2024
… Idiopathic pulmonary fibrosis (IPF) affects an estimated global population of around 3 million individuals. IPF is a medical condition with an … specifically for the treatment of IPF and this has created a demand for the rapid development of drugs …
- 統合MLベースの戦略により特発性肺線維症の薬剤転用を特定
[HTML] Single-cell transcriptomics reveals CD8+ T cell structure and developmental trajectories in idiopathic pulmonary fibrosis
X Wei, C Jin, D Li, Y Wang, S Zheng, Q Feng, W Kong… - Molecular Immunology, 2024
… with idiopathic pulmonary fibrosis. However, the contribution of different immune cell subpopulations to the pathogenesis of pulmonary fibrosis … We used single-cell RNA sequencing data to investigate the transcriptional profiles of immune cells in …
- 単一細胞トランスクリプトミクスにより特発性肺線維症における CD8+ T 細胞の構造と発達経路が明らかに
[HTML] A Commentary on the Role of Pulmonary Function Parameters in Idiopathic Pulmonary Fibrosis Follow‐Up
G Degirmenci, C Satici - The Clinical Respiratory Journal, 2024
… Idiopathic pulmonary fibrosis (IPF) is a progressive disease and has a high mortality rates [ 1 ]. While the overall prognosis of IPF is poor, … for subsequent studies, including genetic analyses and investigation of IPF clinical phenotypes …
- 特発性肺線維症のフォローアップにおける肺機能パラメータの役割に関する解説
Idiopathic pulmonary fibrosis with a typical usual interstitial pneumonia pattern on chest high-resolution computed tomography
A Vancheri, C Ravaglia, S Piciucchi, C Sorino, V Poletti - Rare and Interstitial Lung …, 2025
… , suggesting an idiopathic pulmonaryfibrosis (IPF). Pulmonary … of IPF was made and the patient started antifibrotic therapy and a periodic follow-up to monitor disease progression. The chapter deals with the challenging diagnostic workout and …
- 胸部高解像度コンピュータ断層撮影で典型的な通常型間質性肺炎のパターンを示す特発性肺線維症
Cause or consequence in idiopathic pulmonary fibrosis: using genetic data to back the right horse
LV Wain - Thorax, 2024
… Idiopathic pulmonary fibrosis The task is clear: we need better treatments for pulmonaryfibrosis (PF). The two antifibrotic therapies licensed for idiopathic pulmonary fibrosis(IPF) have shown efficacy in other forms of PF but do not meet the …
- 特発性肺線維症の原因か結果か：遺伝子データを使って正しい馬を応援する
Idiopathic pulmonary fibrosis in a smoker with indeterminate usual interstitial pneumonia pattern on high-resolution computed tomography
F Alfano, C Tirelli, C Sorino, S Centanni, M Mondoni - Rare and Interstitial Lung …, 2025
… Both suggest that he may have idiopathicpulmonary fibrosis (IPF). … He is clinically suspected of having idiopathic pulmonaryfibrosis (IPF). However, HRCT chest findings are indeterminate for UIP, and BAL findings don’t suggest any other …
- 高解像度コンピュータ断層撮影で不確定な通常型間質性肺炎パターンを示す喫煙者の特発性肺線維症
Single-Cell Reveals Novel Immune Perturbations in Fibrotic Hypersensitivity Pneumonitis
AY Zhao, A Unterman, NS Abu Hussein, P Sharma… - American Journal of …, 2024
… In fibrotic HP (FHP), the disease persists, and manifests similarly to other fibrotic lung diseases such as idiopathic pulmonary fibrosis (IPF). Prior research suggests that FHP lungs exhibit increased activated T cells and that peripheral blood …
- 単一細胞が線維性過敏性肺炎における新たな免疫異常を明らかに
Micro-CT-assisted identification of the optimal time-window for antifibrotic treatment in a bleomycin mouse model of long-lasting pulmonary fibrosis
M Buccardi, A Grandi, E Ferrini, D Buseghin, G Villetti… - Scientific reports, 2024
… Idiopathic Pulmonary Fibrosis (IPF) is a debilitating and fatal lung disease characterized by … therapies, whose discovery strongly relies on IPF animal models. Despite some limitations, … This study represents a significant advancement in …
- 長期肺線維症のブレオマイシンマウスモデルにおける抗線維化治療の最適な時間枠のマイクロCT支援による特定
Pulmonary fibrosis and solitary pulmonary nodule in hidden rheumatoid arthritis
R Messina, N Cannizzaro, R Marchese, C Sorino… - Rare and Interstitial Lung …, 2025
… The multidisciplinary team concluded for a diagnosis of idiopathic pulmonary fibrosis(IPF), and the patient started antifibrosant treatment. … UIP pattern on chest HRCT, in the correct epidemiological, clinical, and functional context, usually leads …
- 隠れた関節リウマチにおける肺線維症と孤立性肺結節
24/06/28
Molecular Endotypes of Idiopathic Pulmonary Fibrosis: A Latent Class Analysis of Two Multicenter Observational Cohorts
MV Maddali, AR Moore, P Sinha, CA Newton, JS Kim… - American journal of respiratory …
… a precision medicine approach to IPF. Objective: To identify and validate biologically driven molecular endotypes of IPF. Methods: Latent … Conclusions: In this multicohort study, we identified two novel molecular endotypes of IPF with …
- 特発性肺線維症の分子エンドタイプ：2つの多施設観察コホートの潜在クラス分析
[HTML] Dynamic reporters for probing real-time activation of human fibroblasts from single cells to populations
SE Cassel, BM Huntington, W Chen, P Lei… - APL Bioengineering, 2024
… Specifically, we created a toolset of human lung fibroblast reporter cell lines from different origins (male, female; healthy, idiopathicpulmonary fibrosis) and used three different versions of the reporter with the fluorescent protein modified to exhibit …
- 単一細胞から集団までヒト線維芽細胞のリアルタイム活性化を調査するための動的レポーター
[HTML] Sinomenine ameliorates bleomycin-induced pulmonary fibrosis by inhibiting the differentiation of fibroblast into myofibroblast
Z Nie, J Wu, J Xie, W Yin - Heliyon
… Idiopathic pulmonary fibrosis (IPF) represents a severe interstitial lung disease characterized by limited therapeutic interventions. Recent … of pulmonary fibrosisremains inadequately explored. In the present study, we established a bleomycin (BLM)-induced …
- シノメニンは線維芽細胞から筋線維芽細胞への分化を阻害することでブレオマイシン誘発性肺線維症を改善する。
24/06/27
18β-Glycyrrhetinic Acid Ameliorates Bleomycin-induced Idiopathic Pulmonary Fibrosis via Inhibiting TGF-β1/JAK2/STAT3 Signaling Axis
Y Bai, L Gao, T Han, C Liang, J Zhou, Y Liu, J Guo… - The Journal of Steroid …, 2024
… 18β-GA improves lung function in BLM-induced IPF mice To evaluate the potency of 18β-GA in treating idiopathic pulmonaryfibrosis (IPF), we established a mouse model of IPF by intratracheally instilling bleomycin (BLM, 5 mg/kg) in C57BL/6 mice …
- 18β-グリチルレチン酸はTGF-β1/JAK2/STAT3シグナル伝達軸を阻害することでブレオマイシン誘発性特発性肺線維症を軽減する
Challenges in the management of idiopathic pulmonary fibrosis from a low-and middle-income country
M Chundrigar, AA Khan, S Ansari, MO Awan… - Journal of the Pakistan …, 2024
… Idiopathic pulmonary fibrosis (IPF) is the most common progressive form of interstitial lung disease (ILD) that leads to gradual deterioration … challenges encountered in managing IPF from Pakistan’s largest tertiary care centre. A total of …
- 低・中所得国における特発性肺線維症の管理における課題
[HTML] IPF Pipeline: What is the Current and Future Status on Idiopathic Pulmonary Fibrosis Drug Development
DP Oliver, MF Hossain - J Pharm Compd Ther, 2024
… Effect of recombinant human pentraxin 2 vs placebo on change in forced vital capacity in patients with idiopathic pulmonary fibrosis: a randomized clinical trial. Jama 2018;319(22):2299-2307. … Results of a phase 2 study of GLPG1205 for …
- IPFパイプライン：特発性肺線維症治療薬開発の現状と将来
[HTML] Occupational exposure to respirable crystalline silica and incident idiopathic interstitial pneumonias and pulmonary sarcoidosis: a national prospective follow-up study
IB Iversen, JM Vestergaard, J Ohlander, S Peters… - Occupational and …, 2024
… mainly for the idiopathic interstitial pneumonias. Idiopathic pulmonary fibrosis(IPF) is the most common of the idiopathicinterstitial pneumonias and has been the focus of many previous risk factor studies… Therefore, we did a subanalysis of IPF …
[PDF] Genomic Profiling for Predictive Treatment Strategies in Fibrotic Interstitial Lung Disease
F Perrotta, S Sanduzzi Zamparelli, V D'Agnano… - Biomedicines, 2024
… current studies in IPF and other forms of pulmonary fibrosis, including systemic … Idiopathic pulmonary fibrosis (IPF) is the most studied and common form of idiopathicinterstitial pneumonia (IIP) and serves as the archetype of progressive, self-sustaining …
- 線維性間質性肺疾患の予測治療戦略のためのゲノムプロファイリング
[HTML] The impact of antifibrotic use on long-term clinical outcomes in the pulmonary fibrosis foundation registry
CT Lee, W Hao, CA Burg, J Best, GE Kolenic, ME Strek - Respiratory Research, 2024
… Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal pulmonary condition with high morbidity and median survival of 3–5 years [1]. Crucially, the antifibrotic agents pirfenidone and nintedanib were approved by the Food and Drug …
Enhanced Detection of Early Pulmonary Fibrosis Disease Using 68Ga-FAPI-LM3 PET
J Chen, D Luo, Y Dai, Y Zhou, Y Pang, H Wu, L Sun… - Molecular Pharmaceutics, 2024
… detection of pulmonary fibrosis, leveraging its potential for early disease identification. A bleomycin-induced early pulmonary fibrosismodel was … FAP and SSTR2 expression levels were quantitatively assessed in human idiopathic …
- 68Ga-FAPI-LM3 PET を用いた早期肺線維症の検出の強化
Exploring the role of silica exposure in the aetiology of interstitial lung disorders
D Fishwick, G Calvert, D Yates - Occupational and Environmental Medicine, 2024
… The IIPs likely included idiopathicpulmonary fibrosis (IPF), non-specific interstitial pneumonia (NSIP), the newly emerging genetic … sarcoidosis, none were observed when IPF alone was assessed. This lack of a significant association with IPF is …
- 間質性肺疾患の病因におけるシリカ曝露の役割の調査
[HTML] Outcomes of lung transplantation for pleuroparenchymal fibroelastosis: a French multicentric retrospective study
H Clermidy, O Mercier, G Brioude, P Mordant, G Fadel… - The Journal of Heart and …, 2024
… and consequently the same criteria as in idiopathic pulmonary fibrosis (IPF) are used. However, … In Shiiya’s study, 15 survival was not statistically different between the PPFE and IPF groups, … of PPFE patients, 34.1% deaths in 132 …
- 胸膜実質線維弾性症に対する肺移植の結果：フランスの多施設後ろ向き研究
Prevalence of distress and changes over time among patients with progressive fibrosing interstitial lung disease
山田朋子， ヤマダトモコ
… 1 年間のフォローアップ期間において IPF の患者では労作時呼吸困難の悪化を認めた が,IPF以外の患者では咳症状の… IPF 以外の患者で癌の合併が有意に多かった.登録 患者の うち,半年間で 10 名,その後半年間で 13 名が脱落した.反復測定分散分析の結果,IPF …
- 進行性線維性間質性肺疾患患者における苦痛の有病率と経時的変化
<>
<><><>
特発性肺線維症( idiopathic pulmonary fibrosis (IPF) )関連の学術的情報収集してシェアしています。Google Scholar SearchのUpdateを定期的に掲載しています。GoogleのAIが一定の重み付けはしているとは思いますが、玉石混交です。
当面、毎週アラートの内容をアップしていこうと思います。
###
