ChatGPTを活用して業務のAI化を進めています。プロンプトエンジニアリングの専門家です！と、名乗れるレベルではありませんが、かなり色々使いこなしてきています。この１年、病気で失われた能力は、別な能力を発達させる、進化することで生き残っていこうと思います。
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24/04/20
[HTML] Sirtuins and Cellular Senescence in Patients with Idiopathic Pulmonary Fibrosis and Systemic Autoimmune Disorders
V D'Agnano, DF Mariniello, R Pagliaro, MS Far… - Drugs, 2024
… In this review, we have focused on the role of sirtuins in the pathogenesis of idiopathic and secondary pulmonary fibrosis and their … Idiopathic pulmonary fibrosis (IPF) is the most prevalent idiopathic interstitial lung disease and is more …
- 特発性肺線維症および全身性自己免疫疾患患者におけるサーチュインと細胞老化
[HTML] Prognostic implication of 1-year decline in diffusing capacity in newly diagnosed idiopathic pulmonary fibrosis
H Lee, SY Kim, YS Park, SM Choi, JH Lee, J Park - Scientific Reports, 2024
… Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial lung disease of unknown etiology, with a poor prognosis 1 . Although IPF … Assessment of IPF severity typically involves pulmonary function tests (PFTs) and chest imaging studies …
- 新たに診断された特発性肺線維症における拡散能力の1年間の低下の予後への影響
Diagnostic Approach to Interstitial Lung Diseases Associated with Connective Tissue Diseases
AC Zamora, LJ Wesselius, MB Gotway, HD Tazelaar… - Seminars in Respiratory and …, 2024
… Before categorizing the ILD as idiopathicpulmonary fibrosis (IPF), it is essential to consider and exclude identifiable causes or associations, such as inhalation exposures, drug toxicity, and SARDs.[2] Even though ILDs could be the initial …
- 膠原病に伴う間質性肺疾患の診断アプローチ
Clinical utility, reproducibility, and radiologist acceptance of ILD-RADS
RM El-fawakry, F Zaiton, AM Alsowey, RA Frere… - European Journal of Radiology
… Patients were classified into idiopathicpulmonary fibrosis (IPF) (n = 14) and non-IPFILD (n = 97) groups based on clinical diagnoses determined by multidisciplinary discussion. Association between ILD-RADS categories and clinical diagnoses was …
- ILD-RADS の臨床的有用性、再現性、放射線科医の受け入れ
24/04/19
Commentary: Genetic Association of Circulating Adipokines with Risk of Idiopathic Pulmonary Fibrosis: A Two‑Sample Mendelian Randomization Study
Y Zhang, Q Wen, L Li - Lung, 2024
… Idiopathic pulmonary fibrosis (IPF) is the most common subtype of interstitial lung disease, characterized by chronic progressive pulmonaryfibrosis… Numerous studies have suggested an association between adipokines and IPF. However, due …
- 解説: 循環アディポカインと特発性肺線維症のリスクとの遺伝的関連: 2 サンプルのメンデルランダム化研究
[HTML] The causal relationship between genetically predicted blood metabolites and idiopathic pulmonary fibrosis: A bidirectional two-sample Mendelian randomization study
T Pan, L Bai, D Zhu, Y Wei, Q Zhao, F Feng, Z Wang… - PLOS ONE, 2024
… Numerous metabolomic studies have confirmed the pivotal role of metabolic abnormalities in the development of idiopathic pulmonary fibrosis(IPF). Nevertheless, there is a lack of evidence on the causal relationship between circulating …
- 遺伝的に予測された血液代謝物と特発性肺線維症との因果関係: 双方向 2 サンプルのメンデルランダム化研究
Inhibition of TGF-β1/Smad3 signaling by compound 5aa: A potential treatment for idiopathic pulmonary fibrosis
B An, Y Fang, L Wang, W Nie, M Wang, H Nie, C Wu… - Bioorganic Chemistry, 2024
The incidence of idiopathic pulmonary fibrosis(IPF) has been steadily increasing each year, posing significant challenges in its treatment. In this study, we conducted the design and synthesis of 23 new inhibitors that specifically target the TGF-β1/Smad3 …
- 化合物 5aa による TGF-β1/Smad3 シグナル伝達の阻害: 特発性肺線維症の潜在的な治療法
Transcriptome-Wide Association Study of Idiopathic Pulmonary Fibrosis Survival Identifies PTPN9 and SNRPB2
…, I Noth, A Manichaikul, IPF Survival GWAS Consortium - American Journal of …, 2024
… Idiopathic pulmonary fibrosis (IPF) often leads to chronic respiratory failure and early death. With only two drugs known to slow IPF progression, further understanding of factors contributing to its pathogenesis and progression is needed …
- 特発性肺線維症の生存に関するトランスクリプトームワイド関連研究で PTPN9 と SNRPB2 が特定される
The Regulation of Fatty Acid Synthase by Exosomal miR-143-5p and miR-342-5p in Idiopathic Pulmonary Fibrosis.
H Hayek, O Rehbini, B Kosmider, T Brandt, W Chatila… - American Journal of …, 2024
… Abstract Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive disease caused by an … Our results suggest that IPF-derived exosomes containing miR-143-5p and miR-342-5p … This study highlights the importance of exosomes in IPF …
Aging of alveolar type 2 cells induced by Lonp1 deficiency exacerbates pulmonary fibrosis
W Zhu, C Tan, J Zhang - Biomolecules & biomedicine
… Idiopathic pulmonary fibrosis (IPF) is a progressive and chronic disease that significantly impacts patient quality of life, and its incidence is … and its subsequent effect on IPF development. We generated a bleomycin-induced pulmonaryfibrosis …
- Lonp1欠損により誘発される肺胞2型細胞の老化は肺線維症を悪化させる
[PDF] Quantitative CT in IPF: Is It Time to Act?
L Calandriello - American Journal of Respiratory and Critical Care …, 2024
… Quantification of lung abnormalities on high resolution CT (HRCT) images in patients with idiopathic pulmonary fibrosis (IPF) has been a … First, the deep learning models proposed were tested on the PROFILE dataset, a large prospective …
- IPF における定量的 CT: 行動を起こす時期ですか?
The Oral–Lung Microbiome Axis in Connective Tissue Disease-Related Interstitial Lung Disease
KS Bongers, A Massett, DN O'Dwyer - Seminars in Respiratory and Critical Care …, 2024
… [15] Idiopathic pulmonary fibrosis (IPF) is a poorly understood form of ILD without a clear etiological association.[15] Key studies in … The respiratory microbiome in chronic hypersensitivity pneumonitis is distinct from that of idiopathicpulmonary …
- 結合組織病関連間質性肺疾患における口腔と肺のマイクロバイオーム軸
24/04/18
[PDF] Gastroesophageal reflux disease and idiopathic pulmonary fibrosis risk: A mendelian randomization study
M Lin, J Wang, J Wei, Y Yao, C Tang, W Jin, W Yuan… - European Journal of …, 2024
… Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with unknown etiology and treatment options for it were limited. Whether Gastroesophageal reflux disease (GERD) could affect the occurrence of IPF …
- 胃食道逆流症と特発性肺線維症のリスク：メンデルランダム化研究
[HTML] HE4-based nomogram for predicting overall survival in patients with idiopathic pulmonary fibrosis: construction and validation
M Tian, X Zhu, L Ren, X Zhou, L GU, K Meng, Y Tian… - European Journal of …, 2024
… Idiopathic pulmonary fibrosis (IPF) is a chronic progressive and life-threatening interstitial lung … of IPF is depressing since an expected mean survival for patients upon diagnosis being 2–5 years only [3, 4]. There are no effective drugs to halt or …
- 特発性肺線維症患者の全生存期間を予測するための HE4 ベースのノモグラム: 構築と検証
[PDF] A nonsense mutation PARN (c. 382C> T) in a patient with idiopathic pulmonary fibrosis
CY Wang, L Liu, H Peng, H Luo - QJM: An International Journal of Medicine, 2024
… Idiopathic Pulmonary fibrosis is a progressive pulmonary disorder with a high mortality rate. PARN is a telomere-related pathogenic gene associated with Idiopathic pulmonary fibrosis (IPF). Here, A novel PARN variant (NM_002582.3: p …
- 特発性肺線維症患者におけるナンセンス変異PARN (c. 382C> T)
Involvement of necroptotic cell death in macrophages in progression of bleomycin and LPS-induced acute exacerbation of idiopathic pulmonary fibrosis
A Koike, K Hayashi, K Fujimori - European journal of pharmacology
… Acute exacerbation (AE) of IPF is characterized by progressive lung fibrosis with the irreversible lung function decline and inflammation, … mechanisms in AE of IPF are still not fully understood. In this study, we investigated the mechanism underlying …
- ブレオマイシンおよびLPS誘発性の特発性肺線維症の急性増悪の進行におけるマクロファージの壊死性細胞死の関与
[HTML] Combination of losartan with pirfenidone: a protective anti-fibrotic against pulmonary fibrosis induced by bleomycin in rats
A Amirkhosravi, M Mirtajaddini Goki, MR Heidari… - Scientific Reports, 2024
… Pirfenidone (PFD), one acceptable medication for treating idiopathic pulmonary fibrosis (IPF), is not well tolerated by patients at full doses. Hence, employing of some approaches such as combination therapy may be applicable for increasing …
- ロサルタンとピルフェニドンの組み合わせ：ラットのブレオマイシンによって誘発される肺線維症に対する保護的抗線維化薬
[HTML] Curcumin regulates pulmonary extracellular matrix remodeling and mitochondrial function to attenuate pulmonary fibrosis by regulating the miR-29a-3p/DNMT3A axis
MH Cheng, HF Kuo, CY Chang, JC Chang, IF Liu… - Biomedicine & …, 2024
… to the progression of idiopathic pulmonaryfibrosis (IPF). Curcumin (CCM) in inhibits the progression of pulmonary fibrosis by regulating the … Pulmonary fibrosis was determined using micro-computed tomography and transmission electron …
[PDF] Bibliometric analysis of the pirfenidone and nintedanib in interstitial lung diseases
J Liu, F Wang, Y Hong, F Luo - Heliyon, 2024
… Decade before, pifenidone and 14 nintedanib were approved for idiopathic pulmonary fibrosis, but no more drugs are yet available. To 15 … Idiopathic 51 pulmonary fibrosis (IPF) is the most common type of fibrosing ILD. In 2016, Raghu et …
- 間質性肺疾患におけるピルフェニドンとニンテダニブの書誌学的分析
[HTML] Feasibility and acceptability of remotely monitoring spirometry and pulse oximetry as part of interstitial lung disease clinical care: a single arm observational study
S Barth, C Edwards, G Saini, Y Haider, NP Williams… - Respiratory Research, 2024
… Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic ILD [1]. Usual clinical monitoring of patients with IPF is outlined in … Antifibrotic therapy such as nintedanib or pirfenidone has been shown to slow the physiological decline …
- 間質性肺疾患の臨床ケアの一環としてスパイロメトリーとパルスオキシメトリーを遠隔モニタリングする実現可能性と受容性：単群観察研究
Automatic breathing phase identification based on the second derivative of the recorded lung sounds
R Pal, A Barney - Biomedical Signal Processing and Control, 2024
… : (a) a longitudinal dataset recorded from 19 subjects with a diagnosis of idiopathic pulmonaryfibrosis (IPF), (b) a cross-sectional dataset … recordings from 41 subjects with wheeze (9 with chronic obstructive pulmonary fibrosis and 32 with …
- 記録された肺音の二次導関数に基づく自動呼吸位相識別
Pulmonary Manifestations of Sjögren's Disease
L Byrne, C McCarthy, A Fabre, N Gupta - Seminars in Respiratory and Critical Care …, 2024
… idiopathic pulmonary fibrosis (IPF), pirfenidone and nintedanib, has not been well established in patients with SjD-ILD. Treatment with pirfenidone was associated with an almost 50% relative reduction in the rate of decline in FVC compared with …
- シェーグレン病の肺症状
24/04/16
Protective Effects of Tunisian Orange Co‐Product Extract and Oleuropein‐Hesperidin Combination on Bleomycin‐Induced Pulmonary Fibrosis in Rats
M BEN ABDALLAH, S Bahri, N Afef, M Mona, H Linda… - Chemistry & Biodiversity
… Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial pneumonia that leads to acute lung … (HO) on an experimental model of pulmonary fibrosis induced by bleomycin (BLM) in Wistar … In conclusion, OCE and HO exhibit antifibrotic effects …
- ラットにおけるブレオマイシン誘発性肺線維症に対するチュニジアオレンジ副産物抽出物とオレウロペイン・ヘスペリジンの組み合わせの保護効果
24/04/14
[HTML] A prognostic model of idiopathic pulmonary fibrosis constructed based on macrophage and mitochondria-related genes
Y Bao, S Yang, H Zhao, Y Wang, K Li, X Liu, W Zhang… - BMC Pulmonary Medicine, 2024
… Studies have shown that mitochondrial function and macrophages may play a role in the development of idiopathic pulmonary fibrosis(IPF… of IPF pathogenesis and to find genes associated with IPF pathogenesis we performed differential …
- マクロファージおよびミトコンドリア関連遺伝子に基づいて構築された特発性肺線維症の予後モデル
[PDF] Evaluation of Respiratory Muscle Dysfunction in Patients with Idiopathic Pulmonary Fibrosis: A Prospective Observational Study with Magnetic Resonance Imaging
X Yang, H Wang, A Liu, Y Ni, J Wang, Y Han, B Xie… - 2024
… Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive disorder with an estimated median survival time of 3-5 years after diagnosis[1]. Patient with IPF is characterized by restrictive ventilatory dysfunction, progressively deteriorated …
- 特発性肺線維症患者における呼吸筋機能不全の評価:磁気共鳴画像法による前向き観察研究
Geneticin ameliorates pulmonary fibrosis by attenuating the TGF-β/Smad via modulating AMPK/SIRT1 signaling
SK Tirunavalli, SB Andugulapati - Life Sciences, 2024
… Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive condition with unknown aetiology that causes the lung parenchyma to scar incessantly, lowering the quality of life and hastening death. In this investigation, we studied the anti-fibrotic …
- ジェネティシンは、AMPK/SIRT1 シグナル伝達の調節を介して TGF-β/Smad を弱めることにより肺線維症を改善します。
Protective Effects of Tunisian Orange Co-Product Extract and Oleuropein-Hesperidin Combination on Bleomycin-Induced Pulmonary Fibrosis in Rats
MB Abdallah, S Bahri, N Afef, M Mona, H Linda… - Chemistry & biodiversity
… Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial pneumonia with acute lung damage … (HO) on an experimental model of pulmonary fibrosis induced by bleomycin (BLM). Wistar rats … In conclusion, OCE and HO exhibit antifibrotic …
- ラットにおけるブレオマイシン誘発性肺線維症に対するチュニジアオレンジ副産物抽出物とオレウロペイン-ヘスペリジンの組み合わせの保護効果
Prognostic significance of natural killer cell depletion in predicting progressive fibrosing interstitial lung disease in idiopathic inflammatory myopathies
C Shao, NX Xia, Y Zhen, X Zhang, N Yan, Q Guo - Frontiers in Immunology
… Abstract Objectives: Interstitial lung disease (ILD) is one of the common extramuscular involvement in idiopathic inflammatory myopathies (… Univariate and multivariate Cox analyses were performed to identify the variables significantly …
- 特発性炎症性ミオパチーにおける進行性線維化間質性肺疾患の予測におけるナチュラルキラー細胞枯渇の予後的重要性
24/04/13
Co-Delivery of Astaxanthin and si TGF-β 1 via Ionizable Liposome Nanoparticles for Improved Idiopathic Pulmonary Fibrosis Therapy
X Cao, C Yu, S Cheng, Y Wang, Z Zhang, J Huang - ACS Applied Materials & …, 2024
… of fibroblasts are significant for improving the therapeutic effect of idiopathic pulmonaryfibrosis (IPF). To this aim, ionizable liposome … IPF therapy. ASNPs showed high loading and intracellular delivery efficiency for AST and siTGF-β1. After …
- 特発性肺線維症治療の改善のためのイオン化リポソームナノ粒子を介したアスタキサンチンとsi TGF-β 1の同時送達
Survival and PFT Changes Post Transplant in Patients with Idiopathic Pulmonary Fibrosis
A Ramirez, A Kashem, H Kehara, R Yanagida… - The Journal of Heart and …, 2024
… Idiopathic pulmonary fibrosis (IPF) remains the primary reason for lung transplant. This study investigated how lung allocation score and age of recipient affect patient survivability in patients diagnosed with IPF … to result 416 patients diagnosed with …
- 特発性肺線維症患者における移植後の生存率とPFTの変化
Activation of Fibroblast LRP1 by AT2-Secreted MDK Affects OTUB1/SLC7A11 Ubiquitination to Inhibit Fibroblast Ferroptosis in Idiopathic Pulmonary Fibrosis
H Wenjie, W Zitao, G Fei, W Dong, C Jingyu - The Journal of Heart and Lung …, 2024
… Purpose: Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial fibrosing pneumonia of unknown cause, leading to a poor prognosis. It … by reanalyzing the ScRNA data from the GEO database of normal and IPF patients. Using the cell chart …
- AT2分泌MDKによる線維芽細胞LRP1の活性化はOTUB1/SLC7A11のユビキチン化に影響を及ぼし、特発性肺線維症における線維芽細胞のフェロトーシスを阻害する
Concurrent validity between field tests and cardiopulmonary exercise testing in patients with idiopathic pulmonary fibrosis
HLA Pereira, EV Mancuzo, GA Ribeiro-Samora… - Physiotherapy Theory and …, 2024
… cardiopulmonary exercise testing is the gold standard for assessing functional capacity in patients with idiopathic pulmonary fibrosis (IPF). … Idiopathic pulmonary fibrosis (IPF) is a progressive chronic respiratory disease characterized by a typical …
- 特発性肺線維症患者におけるフィールドテストと心肺運動テストの同時有効性
[HTML] [64Cu] Cu-PEG-FUD peptide for noninvasive and sensitive detection of murine pulmonary fibrosis
HJ Lee, K Bernau, TJ Harr, ZT Rosenkrans, GA Kessler… - Science Advances, 2024
… Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease resulting in irreversible scarring within the lungs. … Idiopathic pulmonaryfibrosis (IPF) is a chronic and progressive lung disease that results in irreversible scarring within the …
- マウス肺線維症の非侵襲的かつ高感度な検出のための [64Cu] Cu-PEG-FUD ペプチド
NKG2D-A Potential Target for Alloreactive CD8 T Cells
K Moghbeli, M Lipp, A Craig, J Sembrat, M Bueno… - The Journal of Heart and …, 2024
… =3), non-diseased lungs (N=3), and from patients with idiopathic pulmonary fibrosis (N=3). Flow cytometry was performed on control and transplant … Results: T cells from explanted CLAD lungs, when compared to control and IPF lungs …
- NKG2D-A アロ反応性 CD8 T 細胞の潜在的な標的
Significance of preoperative exercise oxygen desaturation in lung cancer with interstitial lung disease
T Ueda, K Takamochi, M Fukui, T Ichikawa, A Hattori… - European Journal of Cardio …, 2024
… Idiopathic pulmonary fibrosis, the most common and severe form of ILD, is characterized by progressive fibrosis of the lung parenchyma (5,6) and is associated with a higher incidence of lung cancer (7,8). However, the limited treatment options …
- 間質性肺疾患を伴う肺がんにおける術前の運動酸素飽和度低下の重要性
Dynamic Contrast-Enhanced MRI in Lung Transplantation Recipients with and without CLAD
MH Pierre-Louis, A Susnjar, M Allison, YI Zhou… - The Journal of Heart and …, 2024
… Our group has utilized dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in patients with idiopathic pulmonary fibrosis and other lung diseases, to detect changes reflective of the microvasculature and the extravascular extracellular space …
West Nile Virus Rhombencephalitis Mimicking Hypertrophic Olivary Degeneration (P10-13.003)
A Rubin, A Giebink, E Gettings - Neurology, 2024
… An 84-year-old male with history of idiopathicpulmonary fibrosis presented with an abrupt decline in mental status requiring intubation, in the setting of weeks of progressive dysphagia, ataxia, and lower extremity weakness. He followed some …
- 肥厚性オリーブ変性症を模倣する西ナイルウイルス菱脳炎 (P10-13.003)
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特発性肺線維症( idiopathic pulmonary fibrosis (IPF) )関連の学術的情報収集してシェアしています。Google Scholar SearchのUpdateを定期的に掲載しています。GoogleのAIが一定の重み付けはしているとは思いますが、玉石混交です。
当面、毎週アラートの内容をアップしていこうと思います。
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