ChatGPTを活用して業務のAI化を進めています。プロンプトエンジニアリングの専門家です、、、と、名乗れるレベルではありませんが、使いこなしてきています。
<><><>
23/05/26
[HTML] Characteristics of idiopathic pulmonary fibrosis-associated cough. a case-control study
E Saari, M Mononen, H Hasala, A Lätti, J Kaulamo… - BMC Pulmonary Medicine, 2023
Most patients with idiopathic pulmonary fibrosis (IPF) complain of cough. IPF-associated cough is widely characterized as dry or non-productive. The aim of this study was to compare chronic cough in early stage IPF patients to cough in subjects with chronic …
- 特発性肺線維症に関連する咳の特徴。 症例対照研究
Contributions of ATP12A, a non-gastric proton pump alpha subunit, to the pathogenesis of idiopathic pulmonary fibrosis
X Li, M Abdelgied, K Uhl, O Chen, C Schultz, K Tripp… - Physiology, 2023
… Background: Idiopathic Pulmonary Fibrosis (IPF) is a pathological condition of unknown … The pathogenesis is not clear and there are currently no effective therapies for IPF. Small … may play a role in the pathogenesis of IPF. Methods …
- 特発性肺線維症の病因に対する非胃プロトンポンプαサブユニットであるATP12Aの寄与
Role of Sphingosine Kinase 1 in the Pathogenesis of Idiopathic Pulmonary Fibrosis: Identification of Novel Transcription Factors as Potential Therapeutic Targets by in …
Y Krishnan, T Sudhadevi, R Ramachandran… - Physiology, 2023
… Introduction: Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with no definitive treatment. However, a bioactive lipid mediator, … pathogenesis of IPF. S1P is synthesized from sphingosine by iso-enzymes sphingosine kinase (SPHK) 1 …
- 特発性肺線維症の病因におけるスフィンゴシンキナーゼ 1 の役割: 潜在的な治療標的としての新規転写因子の同定…
Geriatric Nutritional Risk Index is a predictor of tolerability of antifibrotic therapy and mortality risk in patients with idiopathic pulmonary fibrosis
Y Mochizuka, Y Suzuki, M Kono, H Hasegawa… - Respirology (Carlton, Vic.)
… Background and objective: Idiopathic pulmonary fibrosis (IPF) is characterized by progressive lung fibrosis of unknown aetiology. Epidemiological studies have suggested that IPF … The association of nutritional status and outcome has not …
- 高齢者の栄養リスク指数は、特発性肺線維症患者における抗線維化療法の忍容性と死亡リスクの予測因子
[PDF] An Adult Case of Idiopathic Pulmonary Hemosiderosis Associated with Pulmonary Fibrosis and Emphysematous Change
M Kono, Y Oshima, M Katsumata, R Hirama, K Takeda… - Internal Medicine, 2023
… tissue and chronic inflammation, eventually leading to pulmonary fibrosis(2). The formation of … with favorable effects on alveolar bleeding relapse and pulmonary fibrosis progression (1, 2, 5, 14… In conclusion, we encountered a case of IPH …
- 肺線維症と気腫性変化を伴う特発性肺ヘモジデラ症の成人例
Pulmonary Pathology Society Survey on Practice Approaches in the Histologic Diagnosis of Fibrotic Interstitial Lung Disease: Consensus and Opportunities
ML Smith, M Mino-Kenudson, RJ Butterfield, S Dacic… - Archives of Pathology & …, 2023
… features in clinical guidelines for idiopathic pulmonary fibrosis (IPF) in their pathologic … for idiopathic pulmonary fibrosis on pathologists. Arch Pathol Lab Med. 2021;145(6):717–727. … The histologic diagnosis of usual interstitial pneumonia of …
- 肺病理学協会による線維性間質性肺疾患の組織学的診断における実践アプローチに関する調査: コンセンサスと機会
[HTML] Pathologic Criteria for the Diagnosis of Usual Interstitial Pneumonia vs Fibrotic Hypersensitivity Pneumonitis in Transbronchial Cryobiopsies
A Churg, H Tazelaar, R Matej, MK Vasakova, B Stewart… - Modern Pathology, 2023
… (UIP), the pathologic pattern of idiopathic pulmonary fibrosis (IPF; abbreviated here when discussing the biopsies as UIP/IPF); fibrotic … in the COLDICE study, and this is a particularly acute issue for UIP/IPF and conditions such as FHP that can …
- 経気管支凍結生検における通常の間質性肺炎と線維性過敏性肺炎の診断の病理学的基準
Losartan enhances the suppressive effect of pirfenidone on the bleomycin-induced epithelial-mesenchymal transition and oxidative stress in A549 cell line
A Amirkhosravi, M Heidari, S Karami-Mohajeri… - Iranian Journal of Basic …, 2023
… Objective(s): Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease. Despite the promising anti-fibrotic effect, the toleration of pirfenidone (PFD) by the patients in full dose is low. Combination therapy is a method for enhancing the therapeutic …
- ロサルタンは、A549 細胞株におけるブレオマイシン誘導性の上皮間葉転換および酸化ストレスに対するピルフェニドンの抑制効果を増強
SLC40A1 is involved in iron accumulation in human lung fibroblasts
Q Dang, C Huang, Y Liang, S Hewawasam, L Liu - Physiology, 2023
… Iron has been shown to accumulate in alveolar macrophages and is implicated in idiopathic pulmonary fibrosis (IPF). In this study… IPF patients and mice with lung fibrosis induced by bleomycin and asbestos. Iron was partially co-localized with the …
- SLC40A1 はヒト肺線維芽細胞における鉄の蓄積に関与
Rev-erbα agonists suppresses TGFβ1-induced fibroblast-to-myofibroblast transition and pro-fibrotic phenotype in human lung fibroblasts
C Prasad, K Hahn, SK Duraisamy, MA Salathe… - … and Biophysical Research …, 2023
… Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by excessive scarring of the lungs that can lead to respiratory failure and death. Lungs of patients with IPF … Idiopathic pulmonary fibrosis(IPF) is a progressive fibrotic …
- Rev-erbα アゴニストはヒト肺線維芽細胞における TGFβ1 誘導性の線維芽細胞から筋線維芽細胞への移行と線維化促進表現型を抑制
23/05/23
A quantitative analysis of long-term follow-up computed tomography of idiopathic pulmonary fibrosis: the correlation with the progression and prognosis
Y Kunihiro, T Matsumoto, T Murakami, M Shimokawa… - Acta Radiologica, 2023
… Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial pneumonia of unknown cause, associated with a histopathologic and/or … correlate well with pulmonary fibrosis on pathological findings, and high-resolution CT (HRCT) is …
- 特発性肺線維症の長期追跡コンピュータ断層撮影の定量的分析：進行および予後との相関
A novel take on idiopathic pulmonary fibrosis disease progression: localised autoimmunity
M Mukherjee, M Kolb - European Respiratory Journal, 2023
… The arrows indicate key questions that are generated as a result of the study to further understand the demonstrated evidence of autoimmunity in idiopathicpulmonary fibrosis. TGF-β: transforming growth factor-β; TNF-α: tumour necrosis …
- 特発性肺線維症の疾患進行に対する新たな見解：局所的自己免疫
[HTML] Histologic Analysis of Idiopathic Pulmonary Fibrosis by Morphometric and Fractal Analysis
M Mancini, L Bargiacchi, C De Vitis, M D'Ascanio… - Biomedicines, 2023
… In this study, we investigated the fractal morphometry of lung tissue in patients affected by idiopathic pulmonary fibrosis (IPF) with a focus on the usual interstitial pneumonia (UIP) pattern. Our results demonstrate a significant correlation between …
- 形態計測およびフラクタル解析による特発性肺線維症の組織学的解析
[HTML] Treatment of Idiopathic Pulmonary Fibrosis by Inhaled Silybin Dry Powder Prepared via the Nanosuspension Spray Drying Technology
X Ma, K Xia, J Xie, B Yan, X Han, S Li, Y Wang, T Fu - ACS Pharmacology & …, 2023
… The results of this study suggest that silybin spray-dried powder is an attractive candidate for the treatment of IPF. … its efficacy in a bleomycin-induced IPF rat model. We performed gene transcriptomic analysis on rat lungs and further explored …
- ナノ懸濁噴霧乾燥技術によって調製されたシリビン乾燥粉末の吸入による特発性肺線維症の治療
Comparison of clinical scoring to predict mortality risk in mild-to-moderate idiopathic pulmonary fibrosis.
A Sonaglioni, A Caminati, D Elia, R Trevisan… - Minerva Medica, 2023
… Index (CCI), have been separately used to measure comorbidity burden in idiopathic pulmonary fibrosis (IPF). However, no previous study compared the prognostic value of these scores to assess mortality risk stratification in IPFpatients …
- 軽度から中等度の特発性肺線維症における死亡リスクを予測するための臨床スコアの比較。
In vitro modelling of respiratory infections in Idiopathic Pulmonary Fibrosis using patient-specific hiPSC-derived alveolar epithelial cells
ALS Valverde, L Reed, SC Ocaña, PCK Lo, A Tatler… - 2023
… in IPF patients result in an aberrant fibrotic response driven by AT2s. The study of this interaction has been hampered by the lack of adequate human IPFmodels. To better understand this genotype-phenotype relationship, we created an organoid …
Targeted alveolar injury utilizing AAV-DTR mouse model to elucidate the pathophysiology of idiopathic pulmonary fibrosis
D Soetopo, C Mayr, K Fundel-Clemens, F Ramirez… - 2023
… Idiopathic pulmonary fibrosis (IPF) is a fibrotic lung disease with an unclear etiology and a high mortality. The unknown IPF … In conclusion, our AAV-DTR mouse model shows promise in investigating IPF etiology. The longitudinal analysis …
- AAV-DTRマウスモデルを利用した標的肺胞損傷による特発性肺線維症の病態生理の解明
[HTML] Post-COVID-19 Pulmonary Fibrosis: Facts—Challenges and Futures: A Narrative Review
S Duong-Quy, T Vo-Pham-Minh, Q Tran-Xuan… - Pulmonary Therapy, 2023
… It has been hypothesized that PC19-PF patients may benefit from idiopathicpulmonary fibrosis treatment to prevent continued infection-related disorders, enhance the healing phase, and manage fibroproliferative processes …
Association between cytomegalovirus seropositivity and severity of pulmonary fibrosis
A Serezani, B Pascoalino, C Taylor, D Mitchell… - 2023
… at high rates in individuals with Idiopathic pulmonary fibrosis (IPF). Animal models of pulmonary fibrosis using virus infection support the … to understand whether prior herpesvirus infection (based on serology testing) is associated with differences in …
- サイトメガロウイルス血清陽性率と肺線維症の重症度との関連
Lung regeneration for inherited interstitial pulmonary fibrosis using a novel combinatorial AAV gene therapy
P Bardin, L Xu, Y Pei, K Nangle, A Vadivel, S Zhong… - 2023
… Surfactant protein C (SFTPC) gene mutations are amongst the most common forms of inherited disorders of surfactant metabolism as idiopathic pulmonaryfibrosis (IPF). The most frequent mutation I73T results in a SP‑C toxic dominant-negative …
- 新規の併用AAV遺伝子治療を用いた遺伝性間質性肺線維症の肺再生
23/05/20
[PDF] PTX3 regulates immune infiltration and epithelial/fibroblast repair and regeneration in idiopathic pulmonary fibrosis
A d'Amati, R Ronca, F Maccarinelli, M Turati, L Lorusso… - 2023
… the bleomycin (BLM)-induced murine model of Idiopathic PulmonaryFibrosis (IPF). We made a picture of the pulmonary microenvironment … We took advantage of transgenic PTX3 overexpressing mice (Tie2-PTX3) and Ptx3 null ones (PTX3-KO) in …
- PTX3 は、特発性肺線維症における免疫浸潤、上皮/線維芽細胞の修復と再生を調節します。
[HTML] Inositol possesses antifibrotic activity and mitigates pulmonary fibrosis
JM Li, WH Chang, L Li, DC Yang, SW Hsu, NJ Kenyon… - Respiratory Research, 2023
… is known about its effect on idiopathic pulmonary fibrosis (IPF). Recent studies have demonstrated that IPF lung fibroblasts display arginine … Given the emerging role of metabolic reprogramming in IPF pathogenesis, we aimed to reveal potential …
- イノシトールには抗線維化作用があり、肺線維症を軽減します。
Angiopoietin-like 4 is a critical regulator of fibroblasts during pulmonary fibrosis development
S Saito, M Kitabatake, N Ouji-Sageshima, T Ogawa… - American Journal of …, 2023
… An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care … Emerging cellular and molecular determinants of idiopathic pulmonaryfibrosis. Cell Mol Life …
- アンジオポエチン様 4 は肺線維症発症中の線維芽細胞の重要な制御因子です
A roadmap for developing and engineering in vitro pulmonary fibrosis models
M Dabaghi, MB Carpio, N Saraei, JM Moran-Mirabal… - 2023
… Idiopathic pulmonary fibrosis (IPF) is a severe form of progressive pulmonary fibrosis with an unknown cause and a median survival of only 3–5 years after diagnosis, affecting 10 cases per 100000 in the US, with much higher rate in the …
- in vitro 肺線維症モデルの開発およびエンジニアリングのロードマップ
Functional proteomics investigation of biomarkers and molecular pathways suggestive of onset, development, and therapeutic monitoring of different lung disorders
L Vantaggiato - 2023
… the bronchoalveolar lavage fluid (BALF) proteomic signature of lung cancer (LC) in idiopathic pulmonary fibrosis (IPF) patients. … samples from IPF, LC associated with IPF (LC-IPF) patients, and healthy controls (CTRLs) aiming to highlight …
- さまざまな肺疾患の発症、進行、治療モニタリングを示唆するバイオマーカーと分子経路の機能的プロテオミクス研究
Recent Advances in Senolysis for Age-related Diseases
S Aratani, M Nakanishi - Physiology, 2023
… disease (COPD) (134) or idiopathic 348 pulmonary fibrosis (IPF) (135). COPD is characterized by … 352 IPF is a chronic, progressive, and fibrosing interstitial pneumonia of unknown etiology … idiopathic pulmonary fibrosis. Am J Respir Crit …
- 加齢関連疾患に対する老化細胞分解の最近の進歩
Interstitial Pneumonia with Autoimmune Features: 8 Years after Nomenclature and Classification—Where are We Not and Where Are We Headed?
T Kulkarni - Current Pulmonology Reports, 2023
… Connective tissue disease-related ILDs (CTD-ILD) are the most common among ILDs with an established pathological association and portend favorable prognosis compared to idiopathic pulmonary fibrosis (IPF) and other idiopathic interstitial …
Chronic obstructive pulmonary disease and emerging ER stress-related therapeutic targets
JW Yeap, IAH Ali, B Ibrahim, ML Tan - Pulmonary Pharmacology & Therapeutics, 2023
… in idiopathic pulmonary fibrosis (IPF)-induced lung fibroblast cells to diminish profibrotic response and but contrastingly activate autophagy [87]. Currently, a Phase Ib clinical trial is taking place to evaluate the safety and tolerability of …
- 慢性閉塞性肺疾患とERストレス関連の新たな治療標的
Advanced drug-delivery approaches in managing P53-mediated lung diseases remodeling
AA Bhat, R Gilhotra, Y Singh, S Sharma… - Nanomedicine, 2023
… Recent studies revealed that this transcription factor protects against inflammatory lung disorders such as asthma, idiopathic pulmonary fibrosisand chronic obstructive pulmonary disease, which can be fatal. P53 controls several biological activities …
- P53 媒介肺疾患リモデリングの管理における高度な薬物送達アプローチ
23/05/18
An update on current and emerging drug treatments for idiopathic pulmonary fibrosis
A Trachalaki, N Sultana, AU Wells - Expert Opinion on Pharmacotherapy, 2023
… Idiopathic Pulmonary Fibrosis (IPF) is a progressive fibrotic lung disease with a poor prognosis. It affects about 3 million people worldwide [… The aetiology of IPF is complex and not fully understood but it is recognized that the initiation of disease …
- 特発性肺線維症の現在および新規の薬物治療に関する最新情報
[PDF] Isolation, Characterization, and Anti-idiopathic Pulmonary Fibrosis Activity of a Fucoidan from Costaria costata
S Wei, L Geng, H Yu, J Wang, Y Yue, Q Zhang, N Wu - 2023
… Abstract: Pulmonary fibrosis is a chronic, progressive and fatal disease of the interstitial lung. There still lack of efficient therapy to reverse the prognosis of patients currently. In this study, a fucoidan from Costaria costata was isolated and its …
- コスタリア産フコイダンの単離、特性評価、および抗特発性肺線維症活性
The endothelium in lung fibrosis: a core signaling hub in disease pathogenesis?
E Fließer, T Lins, JL Berg, M Kolb, G Kwapiszewska - American Journal of Physiology …, 2023
… pulmonary disease and idiopathic pulmonary fibrosis 590 with pulmonary hypertension. Am J Respir Crit Care Med 190: 98-111, 2014. 591 … matrix metalloproteinases and tissue metalloproteinase inhibitors in patients with idiopathic …
- 肺線維症の内皮: 病気の発症における中核的なシグナル伝達ハブ?
[PDF] Overview on the Link Between the Complement System and Auto-Immune Articular and Pulmonary Disease
P Triggianese, P Conigliaro, E De Martino, B Monosi… - Open Access Rheumatology …, 2023
… Citation57,Citation58 RA-associated UIP (RA-UIP) is difficult to differ from the idiopathic one (eg idiopathic pulmonary fibrosis [IPF]) on HRCT scans. The crucial features include the peripheral- and basal-predominant reticulation and the …
- 補体系と自己免疫性関節疾患および肺疾患との関係に関する概要
23/05/16
[HTML] Genetic association of telomere length, obesity and tobacoo smoking with idiopathic pulmonary fibrosis risk
W Wu, C Li, X Zhu, X Liu, P Li, R Wan, X Wu, S Chen - BMC Public Health, 2023
Due to the inadequacy of published evidence, association of telomere length (TL), obesity and tobacco smoking with idiopathic pulmonary fibrosis (IPF) remains unclear. The aim of the study was to explore whether these exposures genetically …
- テロメア長、肥満、喫煙と特発性肺線維症のリスクとの遺伝的関連
[HTML] Diagnostic finding on high-resolution computed tomography (HRCT) predicts a good response to pirfenidone in patients with idiopathic pulmonary fibrosis
M Ma, M Cao, Y Gao, X Qiu, H Jiang, H Cai - Medicine, 2023
… Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic interstitial pneumonia that … [1,2] IPF is associated with a histopathological pattern of usual interstitial pneumonitis (UIP). [… [2,4] Like other idiopathicinterstitial lung disorders …
- 高解像度コンピュータ断層撮影法 (HRCT) の診断所見は、特発性肺線維症患者におけるピルフェニドンに対する良好な反応を予測する
[HTML] Multiform-based Baduanjin exercise prevention and treatment for idiopathic pulmonary fibrosis: study protocol for a randomized controlled trial
Z Wu, Z Hu, S Ke, L Mo, M Qiu, G Zhu, W Zhu, L Liu - BMC Complementary Medicine …, 2023
… , and/or clubbing fingers should be evaluated for IPF [3]. Currently, the incidence of idiopathic pulmonary fibrosis is increasing globally, with an … Currently, Pirfenidone or Nintedanib monotherapy is the most effective treatment for IPF. These …
- 特発性肺線維症のマルチフォームベースの八端金運動予防と治療：ランダム化比較試験の研究プロトコール
Impact of Biomarkers Associated with CD8+ T cells in Idiopathic Pulmonary Fibrosis on LUSC Immune Infiltration and Construction of CeRNA
X Zhao, Y Hu, A Cui - 2023
… mechanisms and common therapeutic targets between IPF and LC deserve further study. … IPF and cancer, and the potential role of immune checkpoints in IPF is gradually being discovered. PD-1 is highly expressed in both IPF and LC, and …
- 特発性肺線維症における CD8+ T 細胞に関連するバイオマーカーが LUSC 免疫浸潤および CeRNA の構築に及ぼす影響
[PDF] Terapeutic Remission of Community Acquired Pneumonia Caused by Rothia Mucilaginosa in an Adult Patient with Idiopathic Pulmonar Fibrosis
SNN Christo, GAA de Jesus, BCR Jesus - American Journal of Internal Medicine, 2023
… We present the case of a 50-year-old adult patient, without neutropenia, without hematological malignancy, with progressive idiopathic pulmonaryfibrosis (IPF) of 1 … A 50 years old male, having a diagnosis of idiopathicpulmonary fibrosis a year ago …
- 特発性肺線維症の成人患者におけるロチア・ムシラギノーサによる市中肺炎の治療的寛解
[PDF] A possibility of pulmonary intravascular coagulopathy in acute exacerbation of interstitial lung diseases: a retrospective cohort study
Y Takeshita, M To, Y Kurosawa, T Kinouchi, Y Tada… - 2023
… Acute exacerbation (AE) of interstitial lung disease (ILD) is a life-threatening condition that can cause idiopathic pulmonary brosis (IPF) and non-IPF. One of the causes of the poor prognostic outcomes of AE-ILD is believed to be the coagulation …
- 間質性肺疾患の急性増悪における肺血管内凝固障害の可能性：後ろ向きコホート研究
Cuproptosis-related gene CDKN2A as a molecular target for IPF diagnosis and therapeutics
B Xu, K Yang, X Han, J Hou - Inflammation Research, 2023
… Idiopathic pulmonary fibrosis (IPF) is a progressive chronic interstitial lung disease with limited therapeutic options. Cuproptosis is a recently proposed novel form of programmed cell death, which has been strongly implicated in the …
- IPFの診断および治療の分子標的としてのキュプロトーシス関連遺伝子CDKN2A
[HTML] A Case of Pirfenidone Induced Photosensitive Drug Eruption
SH Jeong, EH Hong, EJ Park, KJ Kim, KH Kim - Annals of Dermatology, 2023
… Pirfenidone is an oral anti-fibrotic and anti-inflammatory agent approved for the treatment of idiopathic pulmonary fibrosis (IPF). It inhibits the activity of transforming growth factor β and tumor necrosis factor α, reduces fibroblast proliferation and …
- ピルフェニドンによる光感受性薬剤の噴出の一例
[PDF] Histological Evaluation of The Possible Therapeutic Effect of Pirfenidone on Bleomycin-Induced Pulmonary Fibrosis in Adult Male Albino Rats
HS Bassiouny, N Salama, ASE Habib… - Egyptian Journal of …, 2023
… Introduction and Aim of the Work: Idiopathic pulmonary fibrosis is a disease of unknown etiology that causes fibrosis in lung parenchyma with progressive irreversible nature with no appropriate therapy, so this study worked to evaluate the …
- 成体雄アルビノラットにおけるブレオマイシン誘発性肺線維症に対するピルフェニドンの考えられる治療効果の組織学的評価
Longitudinal Micro CT-driven biomarkers as a tool to evaluate lung fibrosis progression and antifibrotic efficacy in a refined Bleomycin mouse model
Z Khalajzeyqami - 2023
… Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease with no curative pharmacological treatment. Animal models play an … Herein, we have developed an optimized mouse model of pulmonary fibrosis, enabling three weeks …
- 洗練されたブレオマイシンマウスモデルにおける肺線維症の進行と抗線維化効果を評価するツールとしての縦断的マイクロ CT 駆動バイオマーカー
<><><>
特発性肺線維症( idiopathic pulmonary fibrosis (IPF) )関連の学術的情報収集してシェアしています。Google Scholar SearchのUpdateを定期的に掲載しています。GoogleのAIが一定の重み付けはしているとは思いますが、玉石混交です。
当面、毎週アラートの内容をアップしていこうと思います。
###
