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23/04/28
Cloning a profibrotic stem cell variant in idiopathic pulmonary fibrosis
S Wang, W Rao, A Hoffman, J Lin, J Li, T Lin, AA Liew… - Science Translational …, 2023
… The rapid development and fatal progression of idiopathic pulmonary fibrosis (IPF) occur by uncertain mechanisms (1). Emerging hypotheses hold that IPF arises from recurrent, subclinical lung injury that imparts changes to epithelial and stromal cells …
- 特発性肺線維症における線維化促進性幹細胞バリアントのクローニング
IL-8 Concurrently Promotes IPF MPC Senescence and PD-L1 Expression Enabling Escape from Immune Cell Surveillance
L Yang, H Xia, AJ Gilbertsen, K Smith, E Racila… - American Journal of …, 2023
… cell killing of IPF MPCs in vitro and arrests IPFMPC-mediated experimental lung fibrosis in vivo. … CXCR2, we next analyzed IPF lung tissue for IPF MPCs expressing CXCR2 cells (double … fibroblasts drives fibrosis in a humanized model …
- IL-8 は IPF MPC 老化と PD-L1 発現を同時に促進し、免疫細胞監視からの脱出を可能にします
[PDF] Safety, tolerability, pharmacokinetic/pharmacodynamic characteristics of bersiporocin, a novel prolyl-tRNA synthetase inhibitor, in healthy subjects
MY Park, S Bae, JA Heo, M Park, YK Kim, J Han… - Clinical and Translational …, 2023
… Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease of unknown etiology, characterized by excessive accumulation of the extracellular matrix (ECM) in lung tissue, which is associated with proliferation and …
- 新規プロリルtRNA合成酵素阻害剤ベルシポロシンの健常者における安全性、忍容性、薬物動態・薬力学特性
[HTML] Mesenchymal stem cells reversibly de-differentiate myofibroblasts to fibroblast-like cells by inhibiting the TGF-β-SMAD2/3 pathway
R Xu, M Wu, Y Wang, C Li, L Zeng, Y Wang, M Xiao… - Molecular Medicine, 2023
… Although MFBs were historically considered terminally differentiated cells, their potential for de-differentiation was recently recognized and implied with therapeutic value in treating fibrotic diseases, for instance, idiopathic pulmonaryfibrosis (IPF) …
- 間葉系幹細胞は、TGF-β-SMAD2/3 経路を阻害することにより、筋線維芽細胞を線維芽細胞様細胞に可逆的に脱分化させる
Increased clonal hematopoiesis involving DNA damage response genes in patients undergoing lung transplantation
LK Tague, KA Oetjen, A Mahadev, MJ Walter… - JCI Insight, 2023
… Germline variants predisposing to idiopathicpulmonary fibrosis were identified but not associated with CH. DDR CH was associated with increased cytomegalovirus viremia versus patients with no (OR, 7.23 [1.95-26.8], P = 0.018) or …
- 肺移植を受けた患者におけるDNA損傷応答遺伝子が関与するクローン性造血の増加
23/04/25
Discovery of Indoline-based Derivatives as Effective ROCK2 Inhibitors for the Potential New Treatment of Idiopathic Pulmonary Fibrosis
S Fu, Y Wen, B Peng, M Tang, M Shi, J Liu, Y Yang… - Bioorganic Chemistry, 2023
… , IPF threatens human health. Recently, increasing reports have indicated that Rho-associated coiled-coil protein kinases (ROCKs) play important roles in the development of IPFand might represent a novel target for the treatment of IPF …
- 特発性肺線維症の潜在的な新しい治療のための効果的なROCK2阻害剤としてのインドリンベースの誘導体の発見
Features of a telomere syndrome in patients with idiopathic pulmonary fibrosis
TW Hoffman - 2023
This thesis aimed to explore clinical and genetic features of a telomere syndrome in patients with idiopathic pulmonary fibrosis (IPF). IPF is thought to represent a chronic disease process, but the initial stages of disease development remain elusive. Here …
- 特発性肺線維症患者におけるテロメア症候群の特徴
Autoantibodies are associated with disease progression of idiopathic pulmonary fibrosis.
K Köther, V Besnard, H Sandig, A Carruthers… - The European Respiratory …, 2023
… correlates with increased disease severity in patients with IPF. Here we show that patients with IPF have an altered B cell phenotype and … This fibrocyte population was also observed in fibrotic foci of patients with IPF and increased in peripheral …
- 自己抗体は、特発性肺線維症の疾患進行に関連しています。
[PDF] Trends in place of death in patients with idiopathic pulmonary fibrosis: a ten-year analysis of the United States National Center for Health Statistics WONDER database
Y Hadi, AH Sohail, E Schiller, M Oberoi, S Naqvi…
… Idiopathic pulmonary fibrosis (IPF) has a poor prognosis and carries a high mortality rate. For patients with advanced IPF, death at home or in … Incidence and prevalence of idiopathicinterstitial pneumonia and idiopathic pulmonaryfibrosis in …
- 特発性肺線維症患者における死の代わりの傾向：米国国立健康統計センターのWONDERデータベースの10年間の分析
[PDF] Overall drug treatment of idiopathic pulmonary fibrosis patients from national registries–A real-world study
J Kaunisto, ER Salomaa, M Koivisto, M Myllärniemi - 2023
… of idiopathic pulmonary brosis. The objective of this study was to analyse anti brotic and overall prescription medication use of IPFpatients in … The 2010s were pivotal in terms of the diagnostics and treatment of idiopathicpulmonary brosis (IPF) …
- 国家登録からの特発性肺線維症患者の全体的な薬物治療 - 現実世界の研究
Peripheral interstitial lung abnormalities on LDCT in an asymptomatic, nonsmoking Chinese urban cohort
Z Gao, X Li, Y Li, C Zhang, Y Li, M Sun, Y Wu, S Li… - Medicine, 2023
… Idiopathic pulmonary fibrosis (IPF) is one of the representative ILDs, which is considered a disease of aging. [5] Interstitial lung … (CT) which are potentially related to ILD; they are considered as the early or mild form of IPF. [6] ILAs occur in 2 …
- 無症候性の非喫煙中国都市コホートにおけるLDCT上の末梢間質性肺異常
Connective Tissue Disease Associated Interstitial Lung
AI Lung - immunology
… Overall, patients with CTD-ILD have a more favorable outcome compared with those with idiopathic disease, 4 although patients with RA with a UIP pattern are a notable exception and can progress at rates similar to those seen in idiopathic …
- 結合組織病関連間質性肺
Interstitial Lung Disease and Anti-Neutrophil Cytoplasmic
B Matthew Steward, MA Gibbons - immunology
… Around 5% to 10% of patients labeled as having idiopathic pulmonary fibrosis (IPF) have ANCA-positivity documented at diagnosis, 7, 8 with a further 10% developing ANCA-positivity during subsequent follow-up. 9 Notably, these patients are not …
- 間質性肺疾患と抗好中球細胞質
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特発性肺線維症( idiopathic pulmonary fibrosis (IPF) )関連の学術的情報収集してシェアしています。Google Scholar SearchのUpdateを定期的に掲載しています。GoogleのAIが一定の重み付けはしているとは思いますが、玉石混交です。
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