ChatGPTを活用して業務のAI化を進めています。プロンプトエンジニアリングの専門家です！と、名乗れるレベルではありませんが、かなり色々使いこなしてきています。この１年、病気で失われた能力は、別な能力を発達させる、進化することで生き残っていこうと思います。
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23/09/09
Pulmonary Surface Irregularity Score as a New Quantitative CT Marker for Idiopathic Pulmonary Fibrosis—a Pilot Study
AMA Elkassem, R Mresh, A Farag, S Rothenberg… - Journal of Digital Imaging, 2023
… -free survival in the IPF cohort. A subsearch of the full cohort was conducted for keywords including “IPF” and “idiopathic pulmonaryfibrosis”, … Patients without a confirmed diagnosis of IPF in the EMR (N = 6) were excluded. At our institution …
Biomechanical properties of epithelial mesenchymal transition in idiopathic pulmonary fibrosis
M Li, M Sun, Y Jia, H Ren, H Liu - Sheng wu yi xue Gong Cheng xue za zhi= Journal …, 2023
… IPF-EMT in recent years, and provide a systematic review on the effects of alterations in the mechanical microenvironment in pulmonaryfibrosis … and the biomechanical signaling in EMT, in order to provide new references for the research …
- 特発性肺線維症における上皮間葉移行の生体力学的性質
GB0139 (formerly TD139): A potential therapeutic for IPF?
RE WAB
… Idiopathic pulmonary fibrosis (IPF) is a lung disorder characterized by … IPF is TD-139. Here, we delve deeper into the mechanism by which this drug functions and its current status within clinical trials, aiming to simplify concepts and provide hope for …
- GB0139（以前のTD139）：IPFの潜在的な治療法？
[HTML] The emerging roles of SUMOylation in pulmonary diseases
X Zheng, L Wang, Z Zhang, H Tang - Molecular Medicine, 2023
… Idiopathic pulmonary fibrosis (IPF) Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease that is commonly attributed to repeated local micro-injuries to the aging alveolar epithelium. These micro-injuries result in …
- 肺疾患におけるSUMO化の新たな役割
[PDF] An Update on the Diagnosis and Treatment of Interstitial Lung Dis-eases
S Montesi
… Antifibrotic medications, which were initially licenced for IPF, have shown promising outcomes in clinical … idiopathic pulmonaryfibrosis, no medications are approved for the treatment of ILDs (IPF). Immunomodulatory drugs are currently the …
- 間質性肺疾患の診断と治療に関する最新情報
[PDF] CTHRC1: An Emerging Biomarker in Lung Fibrosis
Z Mukhatayev, A Adilbayeva, J Kunz - 2023
… In this review, we will highlight recent studies suggesting that CTHRC1 can serve as a diagnostic and prognostic biomarker for fibrosis in idiopathic pulmonary fibrosis, rheumatoid arthritis-interstitial lung disease, systemic sclerosis, and post-COVID …
- CTHRC1：肺線維症における新しいバイオマーカー
Type 1 invariant natural killer T cells in chronic inflammation and tissue fibrosis
V Kumar, M Hertz, A Agro, A Byrne - Frontiers in Immunology
… Emerging evidence suggests that iNKT-associated mechanisms contribute to type 1, type 2 and type 3 immune pathways mediating tissue fibrosis, including idiopathic pulmonaryfibrosis (IPF). Thus, targeting a pathway upstream of these immune …
- 慢性炎症および組織線維症におけるタイプ1不変ナチュラルキラーT細胞
[PDF] Particulate matter promotes the epithelial to mesenchymal transition in human lung epithelial cells via the ROS pathway
J Zhang, X Xu, Y Liang, X Wu, Z Qian, L Zhang, T Wang - Am J Transl Res, 2023
… idiopathic pulmonary fibrosis (IPF). Several investigations have suggested that the epithelial-to-mesenchymal transition (EMT) may contribute to the complex pathobiology of environmental exposure-mediated pulmonary fibrosis …
- 粒子状物質は、ROS経路を介してヒト肺上皮細胞の上皮から間葉への移行を促進する
Combination of Bronchoalveolar Lavage and CT Differentiates Progressive and Non-Progressive Fibrotic Lung Diseases
JL Barnett, TM Maher, JK Quint, A Adamson, Z Wu… - American Journal of …, 2023
… In patients with idiopathic pulmonaryfibrosis (IPF) and other fibrotic lung diseases, the extent … disease, but none are validated for clinical use and the majority focus on IPF (8-10). … Unlike in patients with IPF, BAL lymphocyte proportion can be …
- 気管支肺胞洗浄とCTの組み合わせにより、進行性肺線維性肺疾患と非進行性線維性肺疾患を区別する
[PDF] Drug–drug interaction prediction of ziritaxestat using a physiologically based enzyme and transporter pharmacokinetic network interaction model
J Perrier, V Gualano, E Helmer, F Namour, V Lukacova… - Clinical and Translational …, 2023
… Ziritaxestat, is a small-molecule, selective autotaxin inhibitor, that was, until recently, under development for the treatment of idiopathicpulmonary fibrosis (IPF) and systemic sclerosis. However, following the outcomes of the Isabela Phase 3 …
- 生理学的に基づく酵素およびトランスポーター薬物動態ネットワーク相互作用モデルを使用したジリタキセスタットの薬物間相互作用予測
23/09/07
[HTML] Genome-wide DNA methylation analysis of Astragalus and Danshen on the intervention of myofibroblast activation in idiopathic pulmonary fibrosis
Q Liu, X Liu, G Wang, F Wu, Y Hou, H Liu - BMC Pulmonary Medicine, 2023
… Idiopathic pulmonary fibrosis (IPF), a chronic progressive interstitial lung disease of unknown etiology, is … for IPF in Western medicine is relatively limited. In contrast, traditional Chinese medicine and compound prescriptions show advantages in the …
- 特発性肺線維症における筋線維芽細胞活性化の介入に関するレンゲとダンシェンのゲノムワイドDNAメチル化解析
Effects of Pulmonary Rehabilitation in Patients with Idiopathic Pulmonary Fibrosis: Integrative Review
ABS Araújo, EV da Silva, MAS Farias, WF Ximenes… - Brazilian Journal of Clinical …, 2024
… Idiopathic Pulmonary Fibrosis (IPF) is a chronic lung condition characterized by progressive … To assess the effectiveness of PR in IPF patients, an integrative review study was conducted, … the need for further research to refine PR protocols …
- 特発性肺線維症患者における呼吸リハビリテーションの効果：統合的レビュー
[HTML] Exosomal miR-17-5p from human embryonic stem cells prevents pulmonary fibrosis by targeting thrombospondin-2
Q Liu, Y Bi, S Song, K Zhu, X Qiao, H Wang, G Ji - Stem Cell Research & Therapy, 2023
… Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and irreversible lung disease characterized by pulmonary fibrosisand lung … We established a bleomycin (BLM)-induced pulmonary fibrosis mice model and administered human …
- ヒト胚性幹細胞由来のエキソソームmiR-17-5pはトロンボスポンジン2を標的とすることで肺線維症を予防する
Causal relationship between lung diseases and risk of esophageal cancer: insights from Mendelian randomization
J Zhou, P Fang, Z Liang, X Li, S Luan, X Xiao, Y Gu… - Journal of Cancer Research …, 2023
… Single-nucleotide polymorphisms (SNPs) related to lung diseases such as asthma, chronic obstructive pulmonary disease (COPD), lung cancer, and idiopathic pulmonary fibrosis(IPF), along with outcomes data on esophageal cancer, were …
- 肺疾患と食道がんのリスクとの因果関係：メンデルランダム化からの洞察
MARCH8 downregulation modulates profibrotic responses including myofibroblast differentiation
X Guo, O Adeyanju, AM Olajuyin, V Mandlem, C Sunil… - American Journal of …, 2023
… Interstitial lung diseases can result in poor patient outcomes, especially in idiopathic 68 pulmonary fibrosis (IPF), a severe interstitial lung … tissues from histologically normal donor and IPF patients showing increased collagen deposition …
- MARCH8のダウンレギュレーションは、筋線維芽細胞の分化を含む線維化促進反応を調節する
Fibrotic Pulmonary Sarcoidosis
H Nunes, PY Brillet, JF Bernaudin, T Gille, D Valeyre… - Clinics in Chest Medicine, 2023
… The natural history of pulmonary fibrosis in light of sarcoid granulomas is still poorly understood. Based on histopathology studies and on … Interestingly, using microdissection of fibroblastic foci on lung explants from patients with idiopathic …
- 線維性肺サルコイドーシス
Monitoring of Sarcoidosis
V Kouranos, AU Wells - Clinics in Chest Medicine, 2023
… Forced vital capacity as a primary end point in idiopathic pulmonary fibrosis treatment trials: making a silk purse from a sow's ear. … Forced vital capacity as a primary end point in idiopathic pulmonary fibrosis treatment trials: making a silk …
- サルコイドーシスのモニタリング
23/09/05
[HTML] Assessing the Burden and Prognostic Value of Cough in Idiopathic Pulmonary Fibrosis
J Johnston, P Rivera-Ortega - Annals of the American Thoracic Society, 2023
… Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease that mainly affects older adults and males (1). Approximately 6,000 new cases of IPF are … The causal relationship between gastro-oesophageal reflux …
- 特発性肺線維症における咳の負担と予後価値の評価
[PDF] Persistent hypoxia promotes myofibroblast differentiation via GPR‐81 and differential regulation of LDH isoenzymes in normal and idiopathic pulmonary fibrosis …
RS Nho, C Rice, J Prasad, H Bone, L Farkas, M Rojas… - Physiological Reports, 2023
… Lactate levels are increased in lungs from patients with idiopathic pulmonary fibrosis(IPF), a … IPF lung fibroblasts to persistent hypoxia and found that increased lactate generation by IPF … significant impact on this marker of differentiation in IPF …
- 持続的な低酸素状態は、ＧＰＲ - ８１を介した筋線維芽細胞の分化を促進し、正常および特発性肺線維症の線維芽細胞におけるＬＤＨアイソザイムの異なる制御を促進する。
Reduced CT-derived erector spinae muscle area: a poor prognostic factor for short-and long-term outcomes in idiopathic pulmonary fibrosis patients
A Çinkooğlu, S Bayraktaroğlu, F Ufuk, ÖS Unat, T Köse… - Clinical Radiology, 2023
… clinical parameters in IPF patients and were also predictors of short and long-term survival. … parameters in IPF patients and were also predictors of short- and long-term survival. … muscle mass is related to a worse prognosis in idiopathic pulmonary …
Pulmonary Nocardiosis following COVID-19 in a patient with idiopathic pulmonary fibrosis and lung transplantation: a case report
L Cao, Y Sun, F Chen - Frontiers in Medicine
… The patient had previously undergone left lung transplantation due to idiopathicpulmonary fibrosis four years ago. He was initially hospitalized and treated for COVID-19 but was readmitted due to worsening symptoms. Subsequently …
[HTML] Autocrine TGF-β-positive feedback in profibrotic AT2-lineage cells plays a crucial role in non-inflammatory lung fibrogenesis
Y Enomoto, H Katsura, T Fujimura, A Ogata, S Baba… - Nature Communications, 2023
… of idiopathic pulmonary fibrosis (IPF) has … Idiopathic pulmonary fibrosis (IPF) is the most common type of interstitial lung disease (ILD) and is a chronic progressive disease with a poor prognosis of less than 5 years after diagnosis 1,2,3 . Molecular …
- 線維化促進性AT2系統細胞における自己分泌TGF-β陽性フィードバックは、非炎症性肺線維形成において重要な役割を果たす
[PDF] Evolving Concepts and Controversies in Interstitial Lung diseases: Update in 2023
P Wawryko, SY Eunhee - Medical Research Archives, 2023
… 1960’s as distinct pathologic pattern of fibrosis in idiopathic pulmonary fibrosis (IPF), the prototype of progressive fibrosing interstitial lung … light on various types of familial pulmonaryfibrosis as well as familial IPF. The concept of progressive …
- 間質性肺疾患における進化する概念と論争：2023年の最新情報
Inhibition of LPA-LPAR1 and VEGF-VEGFR2 Signaling in IPF Treatment
YL Luo, Y Li, W Zhou, SY Wang, YQ Liu - Drug Design, Development and Therapy, 2023
… IPF is the most common Idiopathic interstitial pneumonia (IPF), and its incidence rate and prevalence are increasing. The average life … The pathogenesis of idiopathic pulmonaryfibrosis (IPF) is characterized by an initial acute inflammatory …
- IPF治療におけるLPA-LPAR1およびVEGF-VEGFR2シグナル伝達の阻害
[HTML] Pulmonary inflammation and fibroblast immunoregulation: from bench to bedside
MA Ghonim, DF Boyd, T Flerlage, PG Thomas - The Journal of Clinical Investigation, 2023
… phenotype comparable to those identified in idiopathic pulmonary fibrosis (IPF), and exposure to SARS-CoV-2… Lung macrophages from patients with COVID-19 and those identified in IPF shared … of lung fibroblasts to infection susceptibility in …
- 肺の炎症と線維芽細胞の免疫調節：ベンチからベッドサイドまで
Case Report of Needle Disruption of the Retroperitoneal Lymph Nodes for Refractory Chylothorax After Double Lung Transplantation
H Kagawa, J Stringham, C Selzman, M Goodwin… - Transplantation …, 2023
… We report a case of a 55-year-old man with idiopathic pulmonary fibrosis. He underwent a double lung transplantation with venoarterial extracorporeal membrane support. The surgery was uncomplicated; however, his postoperative course was …
- 難治性乳び胸の両肺移植後の後腹膜リンパ節針破壊の症例報告
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特発性肺線維症( idiopathic pulmonary fibrosis (IPF) )関連の学術的情報収集してシェアしています。Google Scholar SearchのUpdateを定期的に掲載しています。GoogleのAIが一定の重み付けはしているとは思いますが、玉石混交です。
当面、毎週アラートの内容をアップしていこうと思います。
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