ChatGPTなどを活用して業務のAI化を進めています。プロンプトエンジニアリングの専門家です！と、名乗れるレベルではありませんが、かなり色々使いこなしてきています。病気で失われた能力は、別な能力を発達させる、進化することで生き残っていこうと思います。
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25/01/18
[HTML] Gender Differences Are a Leading Factor in 5-Year Survival of Patients with Idiopathic Pulmonary Fibrosis over Antifibrotic Therapy Reduction
P Tondo, G Scioscia, CC De Pace, F Murgolo, F Maci… - Life, 2025
… One of the primary findings from our investigation is that idiopathic pulmonaryfibrosis predominantly affects men; in a sample of 164 … Mexico, which reported a higher incidence of IPF in men than in women. According to this study, IPF affects …
- 性差は、抗線維化療法の減少よりも特発性肺線維症患者の5年生存率を左右する主な要因である
[HTML] Insight into the efficacy and safety of pirfenidone: The treatment of idiopathic pulmonary fibrosis
LY Xu, Y Yu, LS Cen - World Journal of Clinical Cases, 2025
… for idiopathic pulmonary fibrosis (IPF). Lei et al have shown that timely initiation of pirfenidone treatment in individuals diagnosed with IPF can effectively reduce the occurrence of adverse reactions. Moreover, choosing an appropriate …
- ピルフェニドンの有効性と安全性に関する考察：特発性肺線維症の治療
[PDF] Human Pulmonary Fibroblasts (HPF, Idiopathic Pulmonary Fibrosis)
P SHEET
… which might directly or indirectly lead to angiogenesis, idiopathic fibrosis or even cancer [3]. Idiopathic pulmonary fibrosis (IPF) is a rare, progressive illness of the … IPF is believed to be the result of an aberrant wound healing process involving …
- ヒト肺線維芽細胞（HPF、特発性肺線維症）
25/01/17
Complexes that Mitigate or Mediate Fibrosis: Structural and biophysical characterisation of the ERAD checkpoint and the gal-3-fibrosome
CJ Hitchman - 2025
… They have direct relevance to alleviating secretory protein misfolding diseases such as alpha-1 antitrypsin deficiency, and progressive fibrotic lung diseases such as idiopathicpulmonary fibrosis (IPF). … idiopathicpulmonary fibrosis (IPF)…
- 線維症を緩和または媒介する複合体：ERADチェックポイントとGal-3フィブロソームの構造的および生物物理学的特徴
[PDF] EVALUATION OF INTERSTITIAL LUNG DISEASES USING HIGH-RESOLUTION COMPUTED TOMOGRAPHY
MU Khalid, S Ismail, A Arshad, S Javed, B Batool… - The Research of Medical …, 2025
… The imaging enabled subtype differentiation, with idiopathic pulmonary fibrosis (IPF) being the most frequently identified condition. HRCT outperformed chest radiographs in detecting subtle abnormalities, reducing the reliance on invasive …
- 高解像度コンピュータ断層撮影法を用いた間質性肺疾患の評価
[HTML] Relation between pulmonary function changes and diaphragmatic ultrasound in patients with idiopathic pulmonary fibrosis
AA Ibrahim, AMM Abd-Eldayem, HEMA Hamid - The Egyptian Journal of Bronchology, 2025
… Idiopathic pulmonary fibrosis is a condition characterized by declining function and increasing fibrosis without recognized cause [1]. The … Functional parameters are affected in idiopathic pulmonary fibrosis and they are useful in evaluating …
- 特発性肺線維症患者における肺機能変化と横隔膜超音波検査の関係
Evidence mapping of clinical research on traditional Chinese medicine in treatment of idiopathic pulmonary fibrosis
LL Xu, DY Zang, SG Yang, NX Yu, XQ Yu - Zhongguo Zhong yao za zhi= Zhongguo …, 2024
… of idiopathic pulmonary fibrosis(IPF) with traditional Chinese medicine(TCM) and employed evidence mapping to summarize the overall research status and deficiencies of TCM in treating IPF. … attention to acute exacerbation and …
Regulatory T Cell Phenotype Related to Cytokine Expression Patterns in Post-COVID-19 Pulmonary Fibrosis and Idiopathic Pulmonary Fibrosis
S Gangi, L Bergantini, I Paggi, M Spalletti, P Cameli… - Immunity, inflammation and …, 2025
… (PCLF) shares common immunological abnormalities with idiopathic pulmonaryfibrosis (IPF), characterized by an unbalanced cytokine profile … with specific cytokine expression patterns, in peripheral blood (PB) from patients affected by …
- COVID-19 後の肺線維症および特発性肺線維症におけるサイトカイン発現パターンに関連する制御性 T 細胞表現型
Contribution of cuproptosis and immune-related genes to idiopathic pulmonary fibrosis disease
J Liang, J Wang, C Jin, JIA LI, Q Li, L Zhang, S Zheng… - Frontiers in Immunology
… Background: Idiopathic pulmonary fibrosis(IPF) … IPF. Meanwhile, this paper also uses multiple bioinformatics analyses to find immune-related biomarkers associated with the diagnosis of IPF, whi ch can provide more comprehensive …
- 特発性肺線維症における結節炎および免疫関連遺伝子の関与
[HTML] PLAC8 attenuates pulmonary fibrosis and inhibits apoptosis of alveolar epithelial cells via facilitating autophagy
W Sun, B Zhao, Z He, L Chang, W Song, Y Chen - Communications Biology, 2025
… The most prevalent type of idiopathicinterstitial pneumonia is idiopathic pulmonaryfibrosis (IPF), a chronic, progressive, and irreversible lung disease characterized by progressive lung scarring in the interstitium of the lungs 1 …
Effect of Fuzheng Tongluo Granules on macrophage pyroptosis in rat model with pulmonary fibrosis based on NLRP3/caspase-1/GSDMD pathway
F Chen, NF Duan, X Zhang, W Zhang - Zhongguo Zhong yao za zhi= Zhongguo …, 2024
… effect of Fuzheng Tongluo Granules on idiopathic pulmonary fibrosis(IPF) and its mechanism. … Rat model of IPF was induced by a single non-invasive tracheal intubation drip of bleomycin(… can effectively reduce pulmonaryfibrosis and …
- NLRP3/カスパーゼ-1/GSDMD経路に基づく肺線維症ラットモデルにおけるマクロファージピロプトーシスに対する富正銅鑼顆粒の効果
[PDF] AI-Driven Toolset for IPF and Aging Research Associates Lung Fibrosis with Accelerated Aging
F Galkin, S Chen, A Aliper, A Zhavoronkov, F Ren - bioRxiv, 2025
… Idiopathic pulmonary fibrosis (IPF) is a condition predominantly affecting the elderly and leading to a decline in lung function. Our study … out to identify the genes contributing to the progression of both IPF and aging by using ipf-P3GPT. ipf-P3GPT …
- IPF と老化研究のための AI 駆動型ツールセットが肺線維症と加速老化を関連付ける
CircZMYM2 Alleviates TGF-β1-Induced Proliferation, Migration and Activation of Fibroblasts via Targeting miR-199b-5p/KLF13 Axis
Y Han, J Zhao, X Liao, R Wang, L Dong - Applied Biochemistry and Biotechnology, 2025
… Idiopathic pulmonary fibrosis (IPF), featured by progressive lung scarring and consequently aberrant fibroblast accumulation, is a chronic, progressive, and fibrotic pneumonia with increasing incidence and prevalence and poor prognosis [1, 2]. The …
- CircZMYM2はmiR-199b-5p/KLF13軸を標的としてTGF-β1誘導性線維芽細胞の増殖、移動、活性化を軽減する
25/02/15
Challenges of symptom management in interstitial lung disease: dyspnea, cough and fatigue
A Pascoe, AE Holland, N Smallwood - Expert Review of Respiratory Medicine, 2025
… Idiopathic pulmonary fibrosis (IPF) is the most common subvariant. IPF is marked by considerable symptom burden of dyspnea, cough and … Idiopathic pulmonary fibrosis (IPF) is the most common sub-variant characterized by the histological …
- 間質性肺疾患の症状管理の課題：呼吸困難、咳、倦怠感
[PDF] Basic concepts in preserving holistic well-being in interstitial lung diseases
LA Saketkoo, ON Obi, J Varga, JL Poole, C Varju… - 2024
… syndromes and connective tissue diseases, including systemic sclerosis, idiopathicinflammatory myopathies/myositis (IIM), Sjogren syn… ILDs also occur in relation to fewer inflammatory processes, such as idiopathicpulmonary fibrosis (IPF) …
- 間質性肺疾患における総合的な健康を維持するための基本概念
[PDF] The potential therapeutic role of ginsenosides on fibrosis-associated diseases: A review on molecular mechanisms and call for further research
WEI Mengguang, Z Yue, SUN Xiaomeng, QI Lianwen… - Chinese Journal of Natural …, 2024
… as liver fibrosis, myocardial fibrosis, renal fibrosis and pulmonary fibrosis. Ginsenosides have been … treating fibrosis, including nintedanib and pirfenidone for idiopathicpulmonary fibrosis, resmetirom … Unfortunately, nintedanib, an …
25/01/13
Impact of pulmonary rehabilitation on survival in people with Interstitial lung disease
LM Dowman, B Vainshelboim, AE Holland - CHEST, 2025
… Survival is worse in those with idiopathicpulmonary fibrosis (IPF), the most common and severe type of ILD, with median time of 3-5 years. Survival rates are slightly better, although less clearly defined in other ILDs[3,4,5]. Antifibrotic …
- 間質性肺疾患患者の生存に対する呼吸リハビリテーションの影響
to disease activity and the fibrotic radiographic phenotype
H Zhang, D Jiang¹, L Zhu¹, G Zhou¹, B Xie¹, Y Cui… - Regulatory T cells in …, 2025
… 1 cells in the peripheral blood and/or bronchoalveolar lavage fluid (BALF) of 62 sarcoidosis patients, 66 idiopathic pulmonaryfibrosis (IPF) … 1 cells to total Tregs in the peripheral blood of both active and fibrotic sarcoidosis patients, compared with …
- 疾患活動性と線維性放射線学的表現型
25/01/12
Idiopathic Pulmonary Fibrosis in Type 2 Diabetes Mellitus
A Yuwono, M Adisuhanto, A Cahyadi, M Budiman… - Current Respiratory …, 2025
… ) to significantly elevate the risk of IPF, but it found no significant association between T2DM and IPF. Larger clinical cohorts are required to … This review article aimed to enlighten healthcare professionals regarding the co-existence of T2DM …
- 2型糖尿病における特発性肺線維症
[HTML] Nomogram model using serum Club cell secretory protein 16 to predict prognosis and acute exacerbation in patients with idiopathic pulmonary fibrosis
Y Tian, X Zhou, M Tian, L Ren, R Zou, H Jiang, M Xie… - European Journal of …, 2025
… Idiopathic pulmonary fibrosis (IPF) … Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal fibrotic interstitial lung disease with unknown etiology and few treatment options, and the median survival time after diagnosis is 3–5 years [1] …
- 特発性肺線維症患者の予後と急性増悪を予測するための血清クラブ細胞分泌タンパク質16を用いたノモグラムモデル
Idiopathic Interstitial Pneumonias
EN Perez-Rodas, J Sellares, F Hernandez-Gonzalez - … Disease Diagnosis: Systemic …, 2025
… Within the group of chronic fibrosing interstitial pneumonias, idiopathic pulmonary fibrosis(IPF) is characterized by the presence of usual interstitial pneumonia (UIP) in the histological examination of lung parenchyma. The UIP pattern should not be …
- 特発性間質性肺炎
[HTML] Novel functional eQTL-SNPs associated with susceptibility to occupational pulmonary fibrosis: A multi-stage study
R Zhao, X Tao, W Zhang, S Li, S Zhou, A Ning, Z Li… - … and Environmental Safety, 2025
… single-nucleotide polymorphisms (SNPs) that can both affect the susceptibility to idiopathicpulmonary fibrosis (IPF) and silicosis. … We first integrated the genome-wide association studies (GWASs) of IPF and silicosis to obtain the shared SNPs …
- 職業性肺線維症の感受性に関連する新しい機能的 eQTL-SNP: 多段階研究
Inhalable siRNA Targeting IL-11 Nanoparticles Significantly Inhibit Bleomycin-Induced Pulmonary Fibrosis
S Dong, H Fang, J Zhu, Z Wu, Y Liu, J Zhu, B Ma… - ACS nano, 2025
… Idiopathic pulmonary fibrosis (IPF) is a debilitating interstitial lung disease characterized by chronic and progressive nature, which often leads to a poor prognosis. (1) Several factors such as infection, environmental exposures, drug side …
- IL-11ナノ粒子を標的とした吸入可能なsiRNAがブレオマイシン誘発性肺線維症を大幅に抑制
Induction of age-related ocular disorders in a mouse model of pulmonary fibrosis
C Wang, X Li, Q Tang, J Wu, JG Chen - Experimental Eye Research, 2025
… Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease linked to aging. This study investigates potential connections between IPF and age-related eye problems using a bleomycin-induced IPF … injury in mice, followed by IPF with …
- 肺線維症のマウスモデルにおける加齢に伴う眼疾患の誘発
[HTML] Use of and Steering to Pharmacies Owned by Insurers and Pharmacy Benefit Managers in Medicare
P Kakani, S Navangul, CL Luo, KN Tormohlen… - JAMA Health Forum, 2025
… : 18.5%; antipsychotics: 29.5%; cancer: 32.5%; disease-modifying antirheumatic drugs: 41.1%; multiple sclerosis: 64.8%; pulmonary arterial hypertension and idiopathic pulmonaryfibrosis: 89.7%). Nonspecialty classes were less …
- メディケアにおける保険会社および薬局給付管理者が所有する薬局の利用と誘導
[HTML] Comparing multi-texture fibrosis analysis versus binary opacity-based abnormality detection for quantitative assessment of idiopathic pulmonary fibrosis
S Nowak, D Creuzberg, M Theis, C Pizarro, A Isaak… - Scientific Reports, 2025
… Idiopathic pulmonary fibrosis (IPF) is a rare and dangerous disease with high mortality 1 . IPF is characterized by irreversible fibrotic … to delayed diagnosis of IPF 4 . The greater extent of fibrotic tissue changes at the time of delayed diagnosis …
- 特発性肺線維症の定量的評価のためのマルチテクスチャ線維症解析とバイナリ不透明度ベースの異常検出の比較
[PDF] Circulating prostasin is an independent marker of mortality risk in patients with idiopathic pulmonary fibrosis
JL Todd, C Page, P Wu, JA Belperio, TM Maher… - ERJ Open Research, 2025
… Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease (ILD) associated with decline in lung function and high mortality [1]. IPF … The pathobiology of IPFis believed to involve aberrant responses in airway and …
- 循環プロスタシンは特発性肺線維症患者の死亡リスクの独立したマーカーである
[PDF] The histone demethylase KDM6B links obstructive sleep apnea to idiopathic pulmonary fibrosis
S Han, J Huang, C Yang, J Feng, Y Wang - The FASEB Journal, 2025
… Idiopathic pulmonary fibrosis (IPF) represents the most prevalent form of idiopathicinterstitial pneumonia, characterized by a chronic and progressive fibrotic lung disorder. IPF … ), is the main histopathological hallmark of IPF. UIP causes …
- ヒストン脱メチル化酵素KDM6Bは閉塞性睡眠時無呼吸症と特発性肺線維症を結びつける
[PDF] Inhibition of AXL ameliorates pulmonary fibrosis via attenuation of M2 macrophage polarization
DH Kim, K Im, IJ Baek, YJ Choi, H Lee, DS Kim… - European Respiratory …, 2025
… Fifteen patients diagnosed with idiopathicpulmonary fibrosis at Asan Medical Center (Seoul, Republic of Korea) were included in this study. Patients with definite connective tissue disease or a history of exposure to possible causes of interstitial …
- AXL阻害はM2マクロファージ分極の減衰を介して肺線維症を改善する
[PDF] Modified 1-min sit-to-stand test for evaluating exercise capacity in pulmonary fibrosis
I Berger, S Mortada, C Gachie, H Beaussier, E Sacco… - ERJ Open Research, 2025
… 6MWT is routinely used in the management of all types of PF, although most studies on its value have been conducted in patients with idiopathicpulmonary fibrosis (IPF) [5]. This test can be used to assess patient's prognosis, with an …
- 肺線維症における運動能力を評価するための改良1分間座位・立位テスト
[HTML] Orderly Regulation of Macrophages and Fibroblasts by Axl in Bleomycin‐Induced Pulmonary Fibrosis in Mice
X Zhao, Y Li, S Yang, Y Chen, K Wu, J Geng, P Liu… - Journal of Cellular and …, 2025
… Lung tissue and plasma samples were collected from idiopathic pulmonary fibrosis(IPF) patients and healthy controls to assess the Axl levels. We found that Axl inhibited the M1 polarisation of macrophages; inhibition of Axl during acute phase …
- マウスのブレオマイシン誘発性肺線維症における Axl によるマクロファージと線維芽細胞の秩序ある制御
Genome-wide CRISPR/Cas9 screening identifies key profibrotic regulators of TGF-β1-induced epithelial-mesenchymal transformation and pulmonary fibrosis
C Tan, J Wang, X Ye, K Kasimu, Y Li, F Luo, H Yi… - Frontiers in Molecular Biosciences
… The idiopathic pulmonary fibrosis (IPF) is a progressive and lethal interstitial lung disease with high morbidity and mortality. IPF is characterized … To date, few anti-fibrotic therapeutics are available to reverse the progression of pulmonary fibrosis, and it is …
- ゲノムワイドな CRISPR/Cas9 スクリーニングにより、TGF-β1 誘導性上皮間葉系転換および肺線維症の主要な線維化促進因子が特定されました。
[HTML] Genetic analysis shows causal link of GERD, other comorbidities to IPF
TL Kamps
… Relationships between 22 unique comorbidities and idiopathic pulmonaryfibrosis (IPF) were assessed by a bidirectional Mendelian randomization (MR) approach in a retrospective study. Three of the comorbidities that were examined appeared …
- 遺伝子解析により、GERDやその他の合併症とIPFとの因果関係が判明
[PDF] MID of shuttle walk tests in patients with ILD following pulmonary rehabilitation
J Zatloukal, L Houchen-Wolloff, S Ward, F Khan… - ERJ Open Research, 2025
… on the ILD subtype but is typically around 3-5 years after diagnosis in untreated idiopathicpulmonary fibrosis (IPF), the archetypal fibrotic ILD [1]. … Three-month FVC change: a trial endpoint for idiopathic pulmonary fibrosisbased on individual …
[HTML] Consider lifetime costs of condition Consider lifetime costs of condition
MA Moon
… This study glaringly displays potential problems with using ICD codes for research purposes and calls into question results from a handful of studies that yielded epidemiological estimates for idiopathic pulmonary fibrosis. We are …
- 状態の生涯コストを考慮する 状態の生涯コストを考慮する
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特発性肺線維症( idiopathic pulmonary fibrosis (IPF) )関連の学術的情報収集してシェアしています。Google Scholar SearchのUpdateを定期的に掲載しています。GoogleのAIが一定の重み付けはしているとは思いますが、玉石混交です。
当面、毎週アラートの内容をアップしていこうと思います。
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