ChatGPTなどを活用して業務のAI化を進めています。プロンプトエンジニアリングの専門家です！と、名乗れるレベルではありませんが、かなり色々使いこなしてきています。病気で失われた能力は、別な能力を発達させる、進化することで生き残っていこうと思います。
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24/10/19
The impact of COVID-19 infection on idiopathic pulmonary fibrosis mortality: a systematic review and meta-analysis
D Cavasin, U Zanini, L Montelisciani, MG Valsecchi… - … Monaldi per le malattie del torace
… COVID-19 on patients with idiopathicpulmonary fibrosis (IPF). A systematic search … IPF patients with COVID-19. The certainty of evidence was low or very low due to publication bias and heterogeneity. This study underscores the elevated risk …
- COVID-19感染が特発性肺線維症の死亡率に与える影響：系統的レビューとメタアナリシス
[HTML] Exploring the Role of Hemogram-Derived Ratios and Liver Fibrosis Scores in Pulmonary Fibrosis
V Ciornolutchii, VM Ruta, AM Man, NS Motoc, SL Popa… - Medicina, 2024
… The current study aims to evaluate the association between pulmonary fibrosis, both idiopathic and secondary, diagnosed using pulmonary CT, and hepatic steatosis and fibrosis assessed through non-invasive scores and biomarkers. We …
- 肺線維症における血球数比率と肝線維症スコアの役割の調査
Unique transcriptomic profile of peripheral blood monocytes in rheumatoid arthritis-associated interstitial lung disease
JA Poole, A Schwab, GM Thiele, BR England… - Rheumatology, 2024
… Circulating monocytes in RA-ILD patients demonstrate unique gene expression profiles with innate immune gene features more aligned with IPF as opposed to RA in the absence of clinical lung disease with fibrosis gene expression that was distinct …
- 関節リウマチ関連間質性肺疾患における末梢血単球のユニークなトランスクリプトームプロファイル
Macrophage Dysfunction in Respiratory Disease
S Hassibi, LE Donnelly - Results and problems in cell differentiation, 2024
… The common diseases are chronic obstructive pulmonary disease (COPD) and asthma but others that contribute to this statistic include cystic fibrosis and idiopathic pulmonaryfibrosis (IPF). Macrophages are aberrant in all these diseases with a …
- 呼吸器疾患におけるマクロファージ機能不全
Macrophages in Lung Repair and Fibrosis
YAP Jannini-Sá, B Creyns, CM Hogaboam, WC Parks… - Results and problems in cell …, 2024
… Idiopathic Pulmonary Fibrosis, which is the most common fibrosing lung disease, has been … Accumulating evidence suggests that macrophages have a pivotal regulatory role in pulmonary fibrosis… underlying the initiation and progression of …
- 肺の修復と線維化におけるマクロファージ
24/10/18
[HTML] Biomarkers for Early Diagnosis of Idiopathic Pulmonary Fibrosis: A Systematic Review
K Zhai, D Zang, S Yang, Y Zhang, S Niu, X Yu - Journal of Medical and Biological …, 2024
… Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease characterized by high mortality and substantial disease burden… This review aims to systematically overview the role of biomarkers in the early diagnosis of idiopathic …
- 特発性肺線維症の早期診断のためのバイオマーカー：系統的レビュー
[HTML] Identification of PANoptosis-related genes for idiopathic pulmonary fibrosis by machine learning and molecular subtype analysis
L Wu, Y Liu, Y Zhang, R Xu, K Bi, J Li, J Wang, Y Liu… - Scientific Reports, 2024
… Idiopathic pulmonary fibrosis (IPF) is a severe interstitial lung disease characterized by a grim prognosis, in which various forms of cell … in IPF, and to develop reliable diagnostic models based on PANoptosis-related mechanisms. The …
- 機械学習と分子サブタイプ解析による特発性肺線維症のPANoptosis関連遺伝子の同定
[HTML] Real-World Experience in the Clinical Use of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis in Taiwan: A Post-Marketing Surveillance Study
PH Kuo, CY Tu, CH Chen, KC Kao, JY Hsu, MC Lin… - Biomedicines, 2024
Background: Idiopathic pulmonary fibrosis(IPF) is a serious, progressive lung disease for which treatments are scarce. Pirfenidone has been approved for the treatment of IPF in Taiwan since 2016. This study aimed to gain a better insight into …
- 台湾における特発性肺線維症患者に対するピルフェニドンの臨床使用に関する実地経験：市販後調査研究
Persistence of Antifibrotic Therapy in Patients with Idiopathic Pulmonary Fibrosis: A Pulmonary Fibrosis Foundation Patient Registry Study
T Kulkarni, K Flaherty, S Gupta, YH Tu, AH Case - Annals of the American Thoracic …, 2024
… Efficacy and safety of nintedanib in idiopathicpulmonary fibrosis. N Engl J Med. 2014;370(… Safety and survival data in patients with idiopathic pulmonary fibrosis treated with nintedanib: pooled … of clinical trials in idiopathic pulmonary fibrosis …
- 特発性肺線維症患者における抗線維化療法の継続：肺線維症財団患者登録研究
Identifying Mechanism of RSV for the Treatment of COVID-19 and Idiopathic Pulmonary Fibrosis via Suppressing Inflammation Response Through IL-17 Signaling …
J Wang, J Shi, N Jia, Q Sun - Current medicinal chemistry
… Background: Both coronavirus disease 2019 (COVID-19) and idiopathic pulmonary fibrosis(IPF) could cause severe pulmonary injury … pulmonary fibrosis. Objective: The purpose of this research was to investigate the unclear mechanism of …
- IL-17シグナル経路を介した炎症反応の抑制によるCOVID-19および特発性肺線維症の治療におけるRSウイルスのメカニズムをin silico研究の観点から特定
Hermansky-Pudlak Syndrome: An unusual pattern of pulmonary fibrosis
M Donnan, S Ellis, I Glaspole - Respiratory medicine case reports, 2024
… HPS-PF typically occurs earlier in life than idiopathic pulmonary fibrosis (IPF) and there is limited evidence to support the use of antifibrotic therapy. Given the rarity and potential clinical outcomes of the disease, further research is required. This may …
- ヘルマンスキー・パドラック症候群：肺線維症の異常なパターン
[HTML] Pulmonary Fibrosis: Diagnosis and Treatment
ACR Convergence, J Board
… Idiopathic pulmonary fibrosis (IPF) is the most common ILD, with a chronic, progressive course requiring significant healthcare resources. New breakthrough treatments are now available that can potentially delay the progression of the …
- 肺線維症：診断と治療
Meta-Analysis of interobserver agreement in assessment of interstitial lung disease using high-resolution CT
L Delaney, S Alabed, A Maiter, M Salehi, M Goodlad… - Radiology, 2024
… Latinoamericana del Tórax (ATS/ERS/JRS/ALAT) guidelines for idiopathicpulmonary fibrosis (IPF). Meta-analysis was performed using a random-effects model to obtain pooled κ or intraclass correlation coefficient (ICC) values as …
- 高解像度CTを用いた間質性肺疾患の評価における観察者間の合意に関するメタ分析
[HTML] The providing multidisciplinary ILD diagnoses (PROMISE) study–study design of the national registry of Japan facilitating interactive online multidisciplinary …
Y Kondoh, T Furukawa, H Hozumi, T Suda, R Egashira… - BMC Pulmonary Medicine, 2024
… intelligence model to differentiate idiopathicpulmonary fibrosis (IPF) from other chronic … Among ILDs, idiopathic pulmonary fibrosis(IPF) is a chronic, progressively worsening fibrotic lung … diagnosis of IPF has become more …
- 多分野にわたるILD診断の提供（PROMISE）研究 - 日本の全国レジストリの研究デザインは、対話型のオンライン多分野にわたる診断の議論を促進する
Inhalation exposure to chemicals, microbiota dysbiosis and adverse effects on humans
W Utembe, AW Kamng'ona - Science of The Total Environment, 2024
… LM dysbiosis has been associated with multiple respiratory pathologies such as asthma, lung cancer, idiopathic pulmonary fibrosis(IPF), chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). Chemically-induced LM …
- 化学物質の吸入暴露、微生物叢の異常、および人体への悪影響
24/10/14
Drug discovery and development in idiopathic pulmonary fibrosis: the changing landscape
S Cruwys, P Hein, B Humphries, D Black - Drug Discovery Today, 2024
… Idiopathic pulmonary fibrosis (IPF) continues to be a disease with high unmet medical need. In 2020, we reviewed the state of drug discovery efforts for novel IPF … Although this review focuses on IPF, many of the concepts and challenges …
- 特発性肺線維症における新薬の発見と開発：変化する状況
Efficacy and Safety of Admilparant, an LPA1 Antagonist in Pulmonary Fibrosis: A Phase 2 Randomized Clinical Trial
TJ Corte, J Behr, V Cottin, MK Glassberg, M Kreuter… - American Journal of …, 2024
… of predicted forced vital capacity (ppFVC) compared with placebo in parallel idiopathicpulmonary fibrosis (IPF, n=276) and progressive pulmonary fibrosis (PPF, n=123) cohorts. Compared with placebo, 60mg admilparant reduced the rate of …
- 肺線維症における LPA1 拮抗薬アドミルパラントの有効性と安全性: 第 2 相ランダム化臨床試験
Review on the Health Impact of Trace Elements Bound in Inhalable Particles
TI Uza, SO Udo, B Eka, LE Ukam - International Journal of Research and Scientific …, 2024
The health impacts of trace elements bound in inhalable particles is attracting global concern as a result of the toxicological and carcinogenic properties some elements carry. This paper is a review of the effects of trace elements on human health. It is …
- 吸入粒子に結合した微量元素の健康影響に関するレビュー
The anti-fibrotic effect of Lactose-Modified Hyaluronic Acid molecules on primary pulmonary fibroblasts
AC Donato, N Freato, L Bertocchi, A Di Stefano, P Brun - Italian Journal of Anatomy …, 2024
… evaluate in vitro the ability of НА-based molecules functionalized with D-glucose and D-galactose (Hylach®), able to bind Gal-3, to reduce inflammation and fibrosis on human primary pulmonary fibroblasts obtained from normal and idiopathic …
- 乳糖修飾ヒアルロン酸分子の一次肺線維芽細胞に対する抗線維化効果
[HTML] Nintedanib preserves lung growth and prevents pulmonary hypertension in a hyperoxia-induced lung injury model
KL Ding, C Smith, G Seedorf, SH Abman - Pediatric Research, 2024
… lung diseases, particularly idiopathicpulmonary fibrosis (IPF). IPF is also characterized by fibrosis and excessive extracellular matrix and collagen deposition via unregulated proliferation of myofibroblasts. Like BPD, the pathogenesis of IPF …
- ニンテダニブは高酸素誘発性肺障害モデルにおいて肺の成長を維持し、肺高血圧を予防する
24/10/13
Idiopathic Pulmonary Fibrosis Caused by Damaged Mitochondria and Imbalanced Protein Homeostasis in Alveolar Epithelial Type II Cell
Z Dong, X Wang, P Wang, M Bai, T Wang, Y Chu, Y Qin - Advanced biology
… Alveolar epithelial Type II (ATII) cells are closely associated with early events of Idiopathic pulmonary fibrosis (IPF). Proteostasis dysfunction, … pathophysiological initiating event for idiopathic pulmonaryfibrosis. Keywords: ATII cell; IPF; …
- 肺胞上皮細胞II型におけるミトコンドリアの損傷とタンパク質恒常性の不均衡によって引き起こされる特発性肺線維症
[HTML] Study of malnutrition in patients with idiopathic pulmonary fibrosis
AA Dayem, ER Knany, D Ruby - The Egyptian Journal of Chest Diseases and …, 2024
… Although the interest in IdiopathicPulmonary Fibrosis (IPF) has increased in recent years due to the appearance of new therapies … Thus, our study assessed the malnutrition prevalence in patients with IPF and the best indicators for the …
- 特発性肺線維症患者の栄養失調に関する研究
Effect of duration of ECMO application on prolonged mechanical ventilation after lung transplantation in patients with idiopathic pulmonary fibrosis
J Tian, K Jin, S Wang, J Zhang, L Cui, H Xu - 2024
… duration of mechanical ventilation in idiopathic pulmonary fibrosis (IPF) patients undergoing lung … Methods This study included 170 patients with IPF who underwent lung transplantation … Results The gender and ECMO application time …
- 特発性肺線維症患者における肺移植後の長期機械的人工呼吸に対する ECMO 適用期間の影響
Enhanced oxidative stress aggravates BLM-induced pulmonary fibrosis by promoting cellular senescence through enhancing NLRP3 activation
J Feng, H Liu, K Jiang, X Gong, R Huang, C Zhou… - Life Sciences, 2024
… Idiopathic pulmonary fibrosis (IPF) is a disease associated with aging, where increased oxidative stress accelerates the progression of pulmonary fibrosis (PF). The specific mechanisms through which oxidative stress intensifies PF are still not …
- 酸化ストレスの増強は、NLRP3活性化の増強を通じて細胞老化を促進し、BLM誘発性肺線維症を悪化させる。
Interstitial Lung Abnormality: Narrative Review of the Approach to Diagnosis and Management
Z Kattih, B Bade, H Hatabu, K Brown, J Parambil… - CHEST, 2024
… [12, 13] They are considered a potential precursors to idiopathic pulmonary fibrosis(IPF) or other progressive fibrotic ILD depending on … [3, 7, 24-27] This promoter polymorphism is known to be associated with IPF, familial pulmonary …
- 間質性肺疾患：診断と治療へのアプローチに関する叙述的レビュー
[HTML] Antifibrotic effect of disulfiram on bleomycin-induced lung fibrosis in mice and its impact on macrophage infiltration
Y Okabe, E Toda, H Urushiyama, Y Terashima… - Scientific Reports, 2024
… Furthermore, we assessed S100A4 expression in human lung tissue from patients with idiopathic pulmonary fibrosis/usual interstitial pneumonia (IPF/UIP) and control subjects without fibrotic lung disease using multiplex immunofluorescence …
- マウスにおけるブレオマイシン誘発肺線維症に対するジスルフィラムの抗線維化効果とマクロファージ浸潤への影響
Home Monitoring in Interstitial Lung Disease
MA Althobiani - 2024
… Forced vital capacity (FVC) is used as an endpoint in clinical trials for novel idiopathicpulmonary fibrosis (IPF) therapies. However, it is often measured every three months, resulting in lengthy monitoring periods to identify meaningful …
- 間質性肺疾患の在宅モニタリング
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特発性肺線維症( idiopathic pulmonary fibrosis (IPF) )関連の学術的情報収集してシェアしています。Google Scholar SearchのUpdateを定期的に掲載しています。GoogleのAIが一定の重み付けはしているとは思いますが、玉石混交です。
当面、毎週アラートの内容をアップしていこうと思います。
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