ChatGPTを活用して業務のAI化を進めています。プロンプトエンジニアリングの専門家です！と、名乗れるレベルではありませんが、かなり色々使いこなしてきています。この１年、病気で失われた能力は、別な能力を発達させる、進化することで生き残っていこうと思います。
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24/09/07
Targeting the PI3K/mTOR pathway in idiopathic pulmonary fibrosis: Advances and therapeutic potential
Z Wang, Y Guo, K Li, Y Huo, S Wang, S Dong, M Ma - Bioorganic & Medicinal …, 2024
… Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal lung disease characterized by irreversible tissue scarring, leading to severe respiratory dysfunction. Despite current treatments with the drugs Pirfenidone and Nintedanib …
- 特発性肺線維症におけるPI3K/mTOR経路の標的化：進歩と治療の可能性
[PDF] Trajectory of bodyweight and skeletal muscle mass in patients treated with nintedanib for idiopathic pulmonary fibrosis
H Tomioka, T Fujikawa - Clinical Nutrition Open Science
… currently a therapeutic option for 27 idiopathic pulmonary fibrosis (IPF). Weight loss is a common complication of 28 IPF and a side effect of … Thus far, few clinical studies have 30 investigated the relationship between skeletal muscle mass and …
- 特発性肺線維症に対するニンテダニブ治療を受けた患者の体重と骨格筋量の推移
[PDF] Hypersensitivity Pneumonitis: An Interesting Case of Acute Shortness of Breath in a Young Patient
M Rafique, F Arslan, J Khan, S Zaki, A Hussain - Cureus, 2024
… The clinical presentation and radiological and histological findings can overlap with other pulmonary conditions such as idiopathicpulmonary fibrosis. Therefore, it is essential to consider focused assessment for the patient if a diagnosis of HP is …
- 過敏性肺炎：若い患者に起こった急性呼吸困難の興味深い症例
24/09/06
Reevaluating diagnosis in interstitial lung disease with a second multidisciplinary discussion
Y Iijima, H Furusawa, T Yamana, S Shibata, T Shirai… - Respiratory Investigation, 2024
… Of these, 10 patients were initially diagnosed with unclassifiable ILD, and 3 received a low confidence diagnosis of either idiopathicpulmonary fibrosis or idiopathic nonspecific interstitial pneumonia. The most common diagnostic revision …
- 2回目の多職種協議による間質性肺疾患の診断の再評価
24/09/05
Xuanfei Baidu Decoction ameliorates bleomycin-elicited idiopathic pulmonary fibrosis in mice by regulating the lung-gut crosstalk via IFNγ/STAT1/STAT3 axis
M Jia, Y Liu, J Liu, J Meng, J Cao, L Miao, H Zhang… - Phytomedicine, 2024
… Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial pneumonia, the available … microbiota composition with in-site inflammation in IPF development is not yet established. … Idiopathic pulmonary fibrosis(IPF) is a chronic lung …
- 玄飛百度煎じ薬は、IFNγ/STAT1/STAT3軸を介して肺腸間相互作用を調節することにより、マウスのブレオマイシン誘発性特発性肺線維症を改善する
Targeting AnxA2-EGFR signaling: hydroxychloroquine as a therapeutic strategy for bleomycin-induced pulmonary fibrosis
VC Sangamesh, DB Alagundagi, PK Jayaswamy… - … -Schmiedeberg's Archives of …, 2024
… Idiopathic pulmonary fibrosis (IPF) is a disease that causes progressive failure of lung function, and its molecular mechanism remains … slow down the progression of IPF. To better understand the role of the AnxA2-EGFR signaling pathway in …
- AnxA2-EGFRシグナル伝達を標的とする：ブレオマイシン誘発性肺線維症の治療戦略としてのヒドロキシクロロキン
[HTML] Spray drying of a zinc complexing agent for inhalation therapy of pulmonary fibrosis
J Stella, MAME Abdelaal, MAM Kamal, K Shehu… - European Journal of …, 2024
… idiopathic pulmonary fibrosis. Phytic acid, a natural chelator of zinc, which is essential for the activation of metalloproteinase enzymes involved in pulmonary fibrosis, … effective formulation to investigate a new onset for treating pulmonary …
- 肺線維症の吸入療法のための亜鉛錯化剤の噴霧乾燥
[PDF] Respiratory Investigation
K Fujita, A Okada, H Ohkubo, A Nakano, K Ito, Y Mori…
… with 1-year outcomes in IPF. Methods: We evaluated sarcopenia and nutritional status in 64 outpatients with IPF. We assessed the time-toevent … Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic pulmonary disease with high …
- 呼吸器検査
Pathological features of connective tissue disease-associated interstitial lung disease in transbronchial cryobiopsies
A Churg, V Poletti, C Ravaglia, R Matej, MK Vasakova… - Histopathology
… usual interstitial pneumonia (UIP) of idiopathic pulmonary fibrosis (IPF), fibrotic hypersensitivity pneumonitis (… IPF or FHP. Results: A non-specific interstitial pneumonia (NSIP) pattern alone was seen in 36 of 120 (30%) CTD-ILD, three of 83 (3.6%) …
- 経気管支凍結生検における結合組織疾患関連間質性肺疾患の病理学的特徴
[PDF] Evaluating Prescription Patterns, Quality of Life, Therapeutic Adherence, and Pharmaco-Economic Impact in Interstitial Lung Disease Patients: A Study from a Tertiary …
N Kumar
… Results: The study of 84 participants highlights a diverse demographic with a prevalence of hypersensitivity pneumonia and a significant association between smoking and idiopathic pulmonary fibrosis. Methylxanthines and oral corticosteroids …
24/09/04
[HTML] A Triple Mystery of Insidious Organ Failure: Are the Lung, Kidney and Brain All Damaged by the Ageing Pulse?
J Stone, SR Robinson, J Mitrofanis, DM Johnstone - Biomedicines, 2024
… This review explores the hypothesis that dementia in several forms, chronic kidney disease and idiopathic pulmonary fibrosishave a common cause in pulse-induced capillary haemorrhage. All three conditions are age-related and characterised by …
- 潜在的臓器不全の3つの謎：肺、腎臓、脳はすべて加齢による脈拍によって損傷を受けているのか？
24/09/03
[HTML] Secondhand smoke in childhood and adulthood linked to increased risk of rheumatoid arthritis
T Haelle
… At that time, it was already a known genetic risk factor for idiopathic pulmonary fibrosis in the general population. The new data confirm the … At that time, it was already a known genetic risk factor for idiopathic pulmonary fibrosis in the general …
- 小児期および成人期の受動喫煙は関節リウマチのリスク増加につながる
24/09/02
[HTML] Impact of the coronavirus disease 2019 pandemic on hospital admissions for idiopathic pulmonary fibrosis: a nationwide population-based study
IS Cho, J Lim, MS Chang, JH Lee - BMC Pulmonary Medicine, 2024
… Acute exacerbation of idiopathic pulmonaryfibrosis (IPF) is a severe complication with a poor prognosis and high mortality rate. Acute exacerbation of IPF is classified as “triggered acute exacerbation” or “idiopathic acute exacerbation” according to the …
Succinylation-mediated mitochondrial energy metabolism as a potential mechanism for Idiopathic Pulmonary Fibrosis
W Sun, Y Zhao, W Hou, L Yang, K Chen, L Gao
… the first global profiling of Ksucc in fibrotic lung tissues from IPF patients (Data are available via ProteomeXchange with identifier PXD054685)… between control and IPF groups by Using PRM. This study provides insight into Ksucc profile alterations …
[HTML] Safety of Nintedanib in a Patient with Chronic Pulmonary Fibrosis and Kidney Disease
M Maggisano, L Mondini, M Chernovsky… - Pharmaceuticals, 2024
… We describe a case of use of nintedanib in a patient affected by idiopathic pulmonaryfibrosis (IPF) who started, from 2022, nintedanib 150 mg twice a day with careful monitoring of liver and kidney function. Due to the onset of stage 3/4 chronic …
- 慢性肺線維症および腎臓病患者におけるニンテダニブの安全性
The Fibroblast Activation Protein alpha as a biomarker of pulmonary fibrosis
P Lavis, A Garabet, A Kupper Cardozo, B Bondue - Frontiers in Medicine
… Idiopathic pulmonary fibrosis (IPF) is a rare, chronic and progressive interstitial lung disease with an average survival of about 3 years. The evolution of IPF is … Besides IPF, other interstitial lung diseases can lead to pulmonary fibrosis, and up to …
- 肺線維症のバイオマーカーとしての線維芽細胞活性化タンパク質α
Macrophage-fibroblast crosstalk drives Arg1-dependent lung fibrosis via ornithine loading
P Yadav, JG Ortega, W Tamaki, C Chien, KC Chang… - bioRxiv: the preprint server …, 2024
… Imaging of idiopathic pulmonary fibrosis(IPF) lung samples confirmed expression of ARG1 in myeloid cells, and arginase inhibition suppressed collagen expression in cultured precision-cut IPF lung slices. Taken together, we define a circuit between …
- マクロファージと線維芽細胞の相互作用がオルニチン負荷を介してArg1依存性肺線維症を引き起こす
Hypersensitivity pneumonitis to phthalic anhydride: Case description and review of the literature
V van Kampen, A Theile, A Tannapfel, C Eisenhawer… - Allergologie select, 2024
… A clinical case of HP is presented in a cable production worker with exposure to plasticizers who was initially diagnosed with idiopathicpulmonary fibrosis. The presence of specific IgG antibodies (sIgG) to phthalic anhydride in the patient's …
- 無水フタル酸に対する過敏性肺炎：症例報告と文献レビュー
[HTML] Inhalable drug-loaded silk fibroin carriers for pulmonary drug delivery
I D'Onofrio, G De Giorgio, R Sajapin, D Vurro, A Liboà… - RSC Advances, 2024
… of idiopathic pulmonary fibrosis. The aim is to optimize a standard method for the synthesis of SF-based nanocarriers with controlled size and shape, where a fine control of their geometrical properties is aimed at efficiently controlling the …
- 肺への薬物送達のための吸入可能な薬剤充填シルクフィブロインキャリア
24/09/01
Celastrol-Ligustrazine compound proven to be a novel drug candidate for idiopathic pulmonary fibrosis by intervening in the TGF-β1 mediated pathways-an …
L Gao, Y Bai, C Liang, T Han, Y Liu, J Zhou, J Guo… - Molecular Diversity, 2024
… Idiopathic Pulmonary Fibrosis (IPF) is a disease characterized by pulmonary interstitial … collagen deposition, thereby preventing the progression of IPF. In vitro, CL-001 concurrently … IPF effects both in vitro and in vivo, suggesting its potential …
Deep Learning–based Segmentation of Computed Tomography Scans Predicts Disease Progression and Mortality in Idiopathic Pulmonary Fibrosis.
M Thillai, JM Oldham, A Ruggiero, F Kanavati… - American Journal of …, 2024
… Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal condition for which … in the clinic to monitor patients with idiopathic pulmonary fibrosis (IPF): pros and cons. Expert … Modelling forced vital capacity in idiopathic pulmonary …
- ディープラーニングに基づくコンピュータ断層撮影スキャンのセグメンテーションにより、特発性肺線維症の病気の進行と死亡率を予測します。
Exploration of oxidative stress-related hub genes in idiopathic pulmonary fibrosis by integrating bioinformatics analysis
J Huang, L Su, D Wu, M Yuan - 2024
… Idiopathic pulmonary fibrosis (IPF) characterized by a poor prognosis is a chronic and fatal interstitial lung disease. Oxidative stress has great impacts on the initiation and development of IPF. … Idiopathic pulmonaryfibrosis (IPF), a common fatal lung …
- バイオインフォマティクス解析を統合した特発性肺線維症における酸化ストレス関連ハブ遺伝子の探索
Role of telomere dysfunction and immune infiltration in idiopathic pulmonary fibrosis: new insights from bioinformatics analysis
C Fu, X Tian, S Wu, X Chu, Y Cheng, W Yang - Frontiers in Genetics
… Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease characterized by unexplained irreversible pulmonary fibrosis… Using GTEx eQTL data, our SMR analysis identified two genes with potential causal associations …
- 特発性肺線維症におけるテロメア機能不全と免疫浸潤の役割：バイオインフォマティクス解析からの新たな知見
Lipid Nanoparticles for Pulmonary Fibrosis: A Comprehensive Review
TK Dhara, S Khawas, N Sharma - Pulmonary Pharmacology & Therapeutics, 2024
… Idiopathic pulmonary fibrosis (IPF) is a fatal progressive and irreversible ailment … of idiopathic pulmonary fibrosis, along with their drawbacks. The review focuses on different types of lipid-based nanoparticles that have been tested in the treatment of …
- 肺線維症に対する脂質ナノ粒子：包括的レビュー
[PDF] 胸膜肺実質線維弾性症及び特発性肺線維症患者における身体機能の比較検討
馬上修一， 杉野圭史， 須藤美和， 八木田裕治… - 日本呼吸ケア …, 2024
… 不明のものを特発性間質性肺炎(idiopathicinterstitial pneumonias; IIPs)と総称され,現在 は病理組 織パターンに基づき 9 つに分類され,IIPs の中に胸膜肺 実質線維弾性症(pleuroparenchymal fibroelastosis; PPFE) や特発性肺線維症(idiopathic pulmonary fibrosis; IPF) が含まれ …
[HTML] Use of artificial intelligence algorithms to analyse systemic sclerosis-interstitial lung disease imaging features
J Zhao, Y Long, S Li, X Li, Y Zhang, J Hu, L Han, L Ren - Rheumatology International, 2024
… It is important to note that the pathogenesis, treatment, and prognosis of CTD-ILD differ significantly from idiopathic pulmonary fibrosis(IPF), which has the highest incidence rate among ILDs. Unlike IPF, which is characterised by malignant …
24/08/31
Emerging pharmacological options in the treatment of idiopathic pulmonary fibrosis (IPF)
K Aribindi, GY Liu, TE Albertson - Expert Review of Clinical Pharmacology, 2024
… progressive forms of fibrosis of the lung is idiopathic pulmonary fibrosis (IPF). It is a rare disease of … IPF is considered idiopathic and can only be diagnosed when other causes of fibrosing … IPF age-adjusted mortality rates in the United States …
- 特発性肺線維症（IPF）の治療における新たな薬理学的選択肢
The pharmacological and toxicological study of a novel cyclin-dependent kinase 8 inhibitor attenuating pulmonary fibrosis symptoms
CR YANG, TY HE, KC HSU - 日本毒性学会学術年会 第 51 回日本毒性学会学術年会, 2024
… Idiopathic pulmonary fibrosis (IPF) is a chronic, fatal, fibrogenic interstitial lung disease, with a median survival time of 2-3 years. To date, no drug can cure IPF… Thus, the study aims to explore whether the CDK8 inhibitor can attenuate the fibrotic …
- 肺線維症の症状を軽減する新規サイクリン依存性キナーゼ8阻害剤の薬理学的および毒性学的研究
Unraveling the regulatory cell death pathways in pulmonary fibrosis
J Sun, Y Zeng - 2024
… Idiopathic pulmonary fibrosis (IPF) is one of the interstitial lung diseases (ILDs) with poor prognosis. Multiple regulated cell death (RCD) pathways are involved in regulating the progression of pulmonary fibrosis at … Idiopathic pulmonary fibrosis (IPF) …
- 肺線維症における細胞死の制御経路の解明
[HTML] Chlorquinaldol Alleviates Lung Fibrosis in Mice by Inhibiting Fibroblast Activation through Targeting Methionine Synthase Reductase
X Yang, G Lin, Y Chen, X Lei, Y Ou, Y Yan, R Wu… - ACS Central Science, 2024
… Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with limited treatment options. Thus, it is essential to investigate … methionine synthase reductase (MTRR) in lung tissues from idiopathicpulmonary fibrosis (IPF) patients …
Telomere biology disorders: from dyskeratosis congenita and beyond
K Roka, E Solomou, A Kattamis, E Stiakaki - Postgraduate Medical Journal, 2024
… In this context, apart from dyskeratosis congenita, disorders formerly considered idiopathic (ie pulmonary fibrosis, liver cirrhosis) frequently correlate with underlying defective telomere maintenance mechanisms. Moreover, these patients are prone to …
- テロメア生物学的疾患：先天性角化異常症からその先へ
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特発性肺線維症( idiopathic pulmonary fibrosis (IPF) )関連の学術的情報収集してシェアしています。Google Scholar SearchのUpdateを定期的に掲載しています。GoogleのAIが一定の重み付けはしているとは思いますが、玉石混交です。
当面、毎週アラートの内容をアップしていこうと思います。
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