IPF Weekly Update - AIとIPFと癒しの音楽

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23/02/03

[HTML] Central lung gene expression associates with myofibroblast features in idiopathic pulmonary fibrosis

Y Huang, R Guzy, SF Ma, CA Bonham, J Jou… - BMJ Open Respiratory …, 2023

… Idiopathic pulmonary fibrosis (IPF) is the most severe form of interstitial lung

disease and a common indication for lung transplantation.1 … Note that

myofibroblasts markers ACTA1 and ACTA2 were present in the pulmonary fibrosis …

中枢性肺遺伝子発現は、特発性肺線維症における筋線維芽細胞の特徴と関連

[HTML] Cellular and Molecular Mechanisms in Idiopathic Pulmonary Fibrosis

Y Zhang, J Wang - Advances in Respiratory Medicine, 2023

… idiopathic pulmonary fibrosis. We comprehensively summarized the major

inducers and signaling pathways of idiopathic pulmonary fibrosis. … Idiopathic

pulmonary fibrosis (IPF) is a progressively interstitial lung disease with unknown …

特発性肺線維症における細胞および分子メカニズム

[HTML] The Efficacy of Pulmonary Rehabilitation in Patients with Idiopathic Pulmonary Fibrosis

HE Choi, TH Kim, JH Jang, HJ Jang, J Yi, SY Jung… - Life, 2023

… saturation, and health-related quality of life among patients with idiopathic

pulmonary fibrosis (IPF). Methods: A total of 25 patients with IPF (13 in the PR group

and 12 in the non… Further studies in larger samples are needed to evaluate the …

特発性肺線維症患者における肺リハビリテーションの有効性

Is Pulmonary Fibrosis a Precancerous Disease?

M Hosseini, M Salvatore - European Journal of Radiology

… Idiopathic pulmonary fibrosis (IPF) is the most common type of interstitial lung

disease (ILD) characterized by a histopathological pattern of usual … Idiopathic

pulmonary fibrosis (IPF) is the most common type of interstitial lung disease (ILD) …

肺線維症は前がん疾患か？

[HTML] Therapeutic effects of TMF and catechol in pulmonary fibrosis: in vitro and in vivo analysis

JH Choi, Y Kim, M Cho - Applied Biological Chemistry, 2023

… Idiopathic pulmonary fibrosis is a fatal lung disorder characterized by abnormal

deposition of extracellular matrix (ECM), which is secreted … The results showed

that the co-administration of TMF/CAT ameliorated pulmonary fibrosis by decreasing …

肺線維症におけるTMFとカテコールの治療効果：in vitroおよびin vivo分析

MPS Gotarredona, SN Herrero, LG Izquierdo… - Radiología (English Edition), 2022

… that result in various pathological changes and pulmonary fibrosis. A causal

relation has … idiopathic pulmonary fibrosis (IPF); however, the role and impact of

smoking in the development of this differentiated clinical entity, which has also been …

喫煙関連間質性肺疾患

Druggable site near the upper vestibule determines the high affinity and P2X3 selectivity of Sivopixant, a clinical candidate for refractory chronic cough

D Wang, M Zhang, M Li, X Yang, C Li, P Cao, M Zhu… - 2023

… side effects of new RCC clinical candidates from the perspective of receptor-ligand

recognition, which may provide information critical for the development of new drugs

targeting P2X3 for indications such as RCC, idiopathic pulmonary fibrosis (IPF), and …

難治性慢性咳嗽の臨床候補である Sivopixant の高い親和性と P2X3 選択性は、前庭上部近くのドラッグ可能部位によって決定される

[HTML] Outcome following nivolumab treatment in patients with advanced non-small cell lung cancer and comorbid interstitial lung disease in a real-world setting

JB Assié, C Chouaïd, H Nunes, D Reynaud, AF Gaudin… - Therapeutic Advances in …, 2023

… We recently reported a small case series of six patients with mild to moderate

idiopathic pulmonary fibrosis (IPF) treated with nivolumab after at least one line of

platinum-based chemotherapy. The disease control rate was 50%: one patient …

進行性非小細胞肺がんと併存する間質性肺疾患患者におけるニボルマブ治療後の転帰

Interstitial disease associated with connective tissue disease and vasculitis

SH Muñiz, MJO Serrano, JAJ Heffernan, C Valenzuela… - Radiología (English Edition), 2022

… However, in addition to the previously mentioned signs, some features may

suggest connective tissue disease, especially when they appear in an atypical

context for idiopathic pulmonary fibrosis (IPF), such as their presentation in women …

結合組織病および血管炎に関連する間質性疾患

AKI and Renal Recovery After Lung Transplantation: The Experience in Mexico

LMR Topete, P Rodriguez, SS Sanchez-Salazar… - Journal of the American …, 2022

… Idiopathic pulmonary fibrosis the most common diagnosis (58.3%) follow by

COVID-19 (16.6%), 15 receive bi-pulmonary transplant. Survival rate is 66%. 37.5%

developed AKI with the need of KRT all CKRT as initial therapy. …

肺移植後のAKIと腎回復：メキシコでの経験

[PDF] Genomic Fingerprint Associated with Familial Idiopathic Pulmonary Fibrosis: A Review

D Ding, R Gao, Q Xue, R Luan, J Yang - International Journal of Medical Sciences, 2023

… found in f-IPF, this review systematically summarizes the latest progress in the

gene spectrum of the f-IPF population and the underlying mechanisms of f-IPF. The

genetic … This review aims to improve the understanding of the IPF pathogenesis …

家族性特発性肺線維症に関連するゲノムフィンガープリント：レビュー

[PDF] Comparative Analysis of Gene Expression in Fibroblastic Foci in Patients with Idiopathic Pulmonary Fibrosis and Pulmonary Sarcoidosis

L Neubert, JC Kamp, H Stark, JB Hinrichs, C Boekhoff…

… (UIP)/idiopathic pulmonary fibrosis (IPF) and one cardinal feature thought to

represent a key mechanism of pathogenesis. Hence, FF have a high impact on UIP/IPF …

profiles of FF in IPF and sarcoidosis to elucidate similarities and differences as well …

特発性肺線維症患者と肺サルコイドーシス患者における線維芽細胞病巣における遺伝子発現の比較解析

[HTML] Current Perspective on the Role of the Circadian Clock and Extracellular Matrix in Chronic Lung Diseases

K Hahn, IK Sundar - International Journal of Environmental Research and …, 2023

… lung diseases such as asthma, chronic obstructive pulmonary disease (COPD),

and idiopathic pulmonary fibrosis (IPF). Here, we update the current perspective on

the circadian clock role in TGFβ1 signaling and extracellular matrix production …

慢性肺疾患における概日時計と細胞外マトリックスの役割に関する現在の展望

Medical Imaging and Nuclear Molecular Imaging Probes for Pulmonary Fibrosis Diagnosis

HS Ahn, YJ Lee - Journal of Radiopharmaceuticals and Molecular …, 2022

… Idiopathic pulmonary fibrosis (IPF) is a progressive disease caused by some risk

factors, including smoking, viral … pulmonary fibrosis have suffered from breathing

and cough and the average survival rate is only 3 years after diagnosis. Therefore, it …

肺線維症診断のための医用画像および核分子画像プローブ

Detection of impaired gas exchange using the 1-minute sit-to-stand test in patients with interstitial lung disease

K Oishi, M Asami-Noyama, T Yamamoto, K Matsumori… - Respiratory Investigation, 2023

… A recent report showed that patients with idiopathic pulmonary fibrosis (IPF)

commonly experience significant delays in receiving an accurate diagnosis, with the

mean delay from symptom onset to diagnosis being two years [2]. Pulmonary …

間質性肺疾患患者における 1 分間の立位テストを使用したガス交換障害の検出

[HTML] Fibrosis

M Pernia Marin, M Salvatore - Journal of Translational Medicine, 2023

… Fibrosis is the common denominator in a variety of chronic diseases including

idiopathic pulmonary fibrosis, liver cirrhosis, and ulcerative colitis, among others.

These fibrotic diseases affect a vast number of people across the world significantly …

線維症

[HTML] Association of a FAM13A variant with interstitial lung disease in Japanese rheumatoid arthritis

T Higuchi, S Oka, H Furukawa, K Shimada, S Tsunoda… - RMD Open, 2023

… Here, we examined whether a different idiopathic pulmonary fibrosis susceptibility

SNV … This SNV has the strongest association with susceptibility to idiopathic

pulmonary fibrosis.4–8 … In addition to MUC5B, an association of FAM13A with …

日本人関節リウマチにおけるFAM13Aバリアントと間質性肺疾患との関連

[HTML] Clinical spectrum of Chinese hospitalized lung cancer patients with concomitant interstitial lung disease: before and after the new era of LC treatment

R Chen, C Shao, X Liu, H Huang, B Pan, K Xu, R Zhu… - Clinical and Experimental …, 2023

… (CTD)-ILD, drug-induced ILD, radiation pneumonitis, idiopathic interstitial

pneumonia (IIP), etc. [11]. ILDs, especially idiopathic pulmonary fibrosis (IPF), are

associated with an increased risk of LC. IPF conveys a fivefold increased risk of LC …

間質性肺疾患を併発した中国の入院肺癌患者の臨床スペクトル：LC治療の新時代の前後

Idiopathic Pulmonary Fibrosis: State of the Art for 2023.

AJ Podolanczuk, CC Thomson, M Remy-Jardin… - The European Respiratory …, 2023

… Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease

characterized by worsening respiratory symptoms and physiologic … of IPF, more

widespread use of computed tomography scans, and other potential factors have …

特発性肺線維症: 2023 年の最新技術。

H Huang, Z Wang, T Liu - 2023

… the development and progression of idiopathic pulmonary brosis (IPF). The aim of

this study was to explore ERS-related biomarkers in IPF using a bioinformatics

approach and to further investigate their relationship with immune cells. Three IPF …

機械学習に基づく特発性肺線維症における小胞体ストレス関連バイオマーカーの同定

[HTML] Use of Next-Generation Sequencing to Support the Diagnosis of Familial Interstitial Pneumonia

AR Gigante, EM Tinoco, A Fonseca, I Marques… - Genes, 2023

… The most prevalent phenotype was idiopathic pulmonary fibrosis. Pulmonologists

should be … as premature aging disorders such as pulmonary fibrosis, premature

hair graying, bone … gene increases the risk of idiopathic pulmonary fibrosis, either …

家族性間質性肺炎の診断をサポートするための次世代シーケンスの使用

Limited interstitial abnormalities on CT associated with hiatus hernia: a pathogenetic pathway versus an epiphenomenon linked to biologic senescence

PM George, AU Wells - European Respiratory Journal, 2023

… hiatus hernia in patients with pulmonary fibrosis classified as “idiopathic”, “immune

mediated” … idiopathic interstitial pulmonary fibrosis, in which 41 of 48 patients (85%)

had a hiatus hernia. Fast forward 40 years, and the association between hiatus …

裂孔ヘルニアに関連する CT 上の限られた間質性異常：病原性経路と生物学的老化に関連する付帯現象

Radiolabeled GPVI-Fc for PET imaging of multiple extracellular matrix fibers: A new look into pulmonary fibrosis progression.

S Isser, A Maurer, G Reischl, M Schaller… - Journal of Nuclear Medicine, 2023

Invariably fatal and with a particularly fast progression, pulmonary fibrosis (PF) is

currently devoid of curative treatment option. Routine clinical diagnosis relies on

breathing tests and visualizing the changes in lung structure by computed …

複数の細胞外マトリックス繊維の PET イメージングのための放射標識された GVI-Fc: 肺線維症の進行に関する新たな考察。

[HTML] Design, synthesis, and biological evaluation of indolin-2-one derivatives as novel cyclin-dependent protein kinase 8 (CDK8) inhibitors

JY Hsu, KC Hsu, C Sun, CH Chou, TE Lin, TY Sung… - Biomedicine & …, 2023

… Long-term chronic inflammation of the lungs can lead to idiopathic pulmonary

fibrosis (IPF). Abnormal alveolar epithelial regeneration leads to the release of

various fibrotic growth factors and the activation of inflammatory cells. CDK8 …

新規サイクリン依存性プロテインキナーゼ 8 (CDK8) 阻害剤としてのインドリン-2-オン誘導体の設計、合成、および生物学的評価

[PDF] Understanding Interstitial Lung Diseases Associated with Connective Tissue Disease (CTD-ILD): Genetics, Cellular Pathophysiology, and Biologic Drivers

G Cerro Chiang, T Parimon - International Journal of Molecular Sciences, 2023

… idiopathic interstitial pneumonias which include idiopathic pulmonary fibrosis (IPF)

and nonspecific interstitial pneumonias (NSIP) [4,5]. Among all these, IPF is … Here,

we describe multiple cell types in idiopathic and non-idiopathic forms of lung fibrosis …

結合組織病（CTD-ILD）に関連する間質性肺疾患の理解：遺伝学、細胞病態生理学、および生物学的要因