視点—特発性肺線維症のために：予備的観察

[HTML] The Eyes Have It—for Idiopathic Pulmonary Fibrosis: a Preliminary Observation

RA Pleasants, AD Bedoya, JM Boggan, K Welty-Wolf… - Pulmonary Therapy, 2022

… persons, including idiopathic pulmonary fibrosis (IPF). On the basis of prior

clinical observation of an association between light eye color and IPF, we explored

this association further in a database containing medical records of a population …

Abstract
Introduction: The disease origins of idiopathic pulmonary fibrosis (IPF), which occurs at higher rates in certain races/ethnicities, are not understood. The highest rates occur in white persons of European descent, particularly those with light skin, who are also susceptible to lysosomal organelle dysfunction of the skin leading to fibroproliferative disease . We had observed clinically that the vast majority of patients with IPF had light-colored eyes, suggesting a phenotypic characteristic.

Methods: We pursued this observation through a research database from the USA Veterans Administration, a population that has a high occurrence of IPF due to predominance of elderly male smokers. Using this medical records database, which included facial photos, we compared the frequency of light (blue, green, hazel) and dark (light brown, brown) eyes among white patients diagnosed with IPF compared with a control group of lung granuloma only (no other radiologic evidence of interstitial lung disease).

Results: Light eye color was significantly more prevalent in patients with IPF than in the control group with lung granuloma [114/147 (77.6%) versus 129/263 (49.0%], p < 0.001), indicating that light-colored eyes are a phenotype associated with IPF .

Conclusion: We provide evidence that light eye color is predominant among white persons with IPF.
視点—特発性肺線維症のために：予備的観察
概要
はじめに: 特定の人種/民族でより高い割合で発生する特発性肺線維症 (IPF) の疾患の起源は理解されていません。発生率が最も高いのは、ヨーロッパ系の白人、特に肌の色が薄い人で、皮膚のリソソームオルガネラ機能不全に陥りやすく、線維増殖性疾患につながる . 私たちは、IPF患者の大多数が明るい色の目をしていることを臨床的に観察しており、表現型の特徴を示唆しています.

方法: 米国退役軍人管理局 (高齢の男性喫煙者が優勢であるために IPF の発生率が高い集団) からの研究データベースを通じて、この観察を追跡しました。顔写真を含むこの医療記録データベースを使用して、肺肉芽腫のみの対照群と比較して、IPFと診断された白人患者の明るい（青、緑、ヘーゼル）および暗い（明るい茶色、茶色）目の頻度を比較しました（無間質性肺疾患の他の放射線学的証拠）。

結果: IPF 患者では、肺肉芽腫の対照群よりも明るい目の色が有意に多く見られた [114/147 (77.6%) vs 129/263 (49.0%)、p < 0.001)。 IPF に関連する表現型。

結論: 私たちは、IPF を持つ白人の間で明るい目の色が優勢であるという証拠を提供します。