IPF Weekly Update
ChatGPTなどを活用して業務のAI化を進めています。プロンプトエンジニアリングの専門家です！と、名乗れるレベルではありませんが、かなり色々使いこなしてきています。病気で失われた能力は、別な能力を発達させる、進化することで生き残っていこうと思います。
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24/11/21
[HTML] Prognostic value of the 6-minute walk test derived attributes in patients with Idiopathic Pulmonary Fibrosis
AEM Bloem, HM Dolk, AE Wind, JJ van der Vis… - Respiratory Medicine
… Idiopathic pulmonary fibrosis (IPF) is a fatal progressive fibrosing lung disease. A decreased 6-minute walk distance (6MWD) and exercise… predictors of mortality in patients with IPF. However, the use of antifibrotic drugs showed a survival benefit in …
- 特発性肺線維症患者における6分間歩行テストから得られた特性の予後価値
[PDF] The respiratory microbiome in patients with post-COVID-19 residual lung abnormalities resembles that of healthy individuals and is distinct from IPF
DJF Smith, NMY Teng, EK Denneny, P Mehta… - ERJ Open Research, 2024
… It has been speculated that these residual parenchymal changes may reflect pathological processes similar to mechanisms underlying interstitial lung diseases (ILD) such as idiopathicpulmonary fibrosis (IPF) and fibrotic hypersensitivity pneumonitis (fHP) …
- COVID-19感染後に肺に異常が残存する患者の呼吸器系微生物叢は健康な人のものと類似しており、IPFとは異なる。
Allium sativum nanovesicles exhibit anti-inflammatory and antifibrotic activity in a bleomycin-induced lung fibrosis model
JC Santos-Álvarez, JM Velázquez-Enríquez… - Molecular Biology Reports, 2024
… Idiopathic pulmonary fibrosis (IPF) is a chronic and highly fatal disease characterized by excessive accumulation of extracellular matrix (ECM), foci of myofibroblasts, and a usual pattern of interstitial pneumonia. As suggested by …
- ネギナノベシクルはブレオマイシン誘発肺線維症モデルにおいて抗炎症および抗線維化活性を示す
[HTML] MOSES: a methylation-based gene association approach for unveiling environmentally regulated genes linked to a trait or disease
S Kim, Y Qin, HJ Park, RIC Bohn, M Yue, Z Xu, E Forno… - Clinical Epigenetics, 2024
… of persons with idiopathic pulmonaryfibrosis and control subjects. … idiopathicpulmonary fibrosis (IPF) To evaluate the performance of MOSES-DNAm 10 M in a disease other than asthma, we applied the model to lung samples from persons with …
- MOSES: メチル化に基づく遺伝子関連アプローチにより、形質や疾患に関連する環境調節遺伝子を明らかにする
[HTML] Protocol and research program of the European registry and biobank for interstitial lung diseases (eurILDreg)
E Krauss, S Tello, J Naumann, S Wobisch, C Ruppert… - BMC Pulmonary Medicine, 2024
… pulmonary fibrosis (PPF) phenotype and, ultimately, a fatal course, similar to the Idiopathic … and progression are limited and are mostly confined to IPF, one of the more frequent and … For instance, in prior investigations on Idiopathic Pulmonary …
Role of Antioxidant Therapy in Respiratory Disease Management
B Bhattacharya, N Devi, Sanshita, A Sharma, V Puri… - … : Nature's Defense Against …, 2025
… Idiopathic Pulmonary Fibrosis (IPF) Idiopathic pulmonary fibrosis (IPF) also known as cryptogenic fibrosing alveolitis is a persistent, incurable, rare and progressive disease with different and unknown etiologic backgrounds and diverse …
- 呼吸器疾患管理における抗酸化療法の役割
Challenges and opportunities of the artificial intelligence in respiratory medicine
S Vlada - MedEspera 2024, 2024
… of conditions like acute respiratory distress syndrome (ARDS), idiopathic pulmonaryfibrosis, COPD and other obstructive lung diseases. AI-… conditions like acute respiratory distress syndrome (ARDS), idiopathicpulmonary fibrosis, COPD …
- 呼吸器医学における人工知能の課題と機会
CITRULLINATED AND MALONDIALDEHYDE-ACETALDEHYDE MODIFIED FIBRINOGEN ACTIVATES MACROPHAGES AND PROMOTES PROFIBROTIC …
N Aripova, MJ Duryee, W Zhou, BR England… - American Journal of …, 2024
… characteristics with idiopathic pulmonaryfibrosis (IPF). In 112 addition to shared epidemiological risk factors(15, 16), RA-ILD manifests most commonly in a 113 usual interstitial pneumonia (UIP) universal to IPF. The UIP pattern is characterized …
24/11/20
[PDF] KL‑6, ET‑1 and S100A9 levels in patients with idiopathic pulmonary fibrosis and obstructive sleep apnea
I Bouloukaki, S Michelakis, E Tsitoura, E Vasarmidi… - … and Therapeutic Medicine, 2025
… ) and idiopathic pulmonary fibrosis (IPF) frequently coexist. Elevated levels of Krebs von den Lungen‑6 (KL‑6), endothelin‑1 (ET‑1) and S100 calcium‑binding protein A9 (S100A9) have been observed in patients with IPF, … Idiopathic …
- 特発性肺線維症および閉塞性睡眠時無呼吸症患者におけるKL-6、ET-1、S100A9レベル
Unravelling the role of sFRP2 in the pathogenesis of Idiopathic Pulmonary Fibrosis
I Tomos, M Shira, D Fanidis, P Kanellopoulou, V Aidinis - 2024
… in Idiopathic Pulmonary Fibrosis. Through a machine learning pipeline using Fibromine, a multi-omics database, soluble Frizzled related protein 2 (sFRP2) was strongly suggested to have a role in IPF … The aim of the study is to investigate the …
- 特発性肺線維症の発症における sFRP2 の役割を解明
Investigation of the gut microbiata profiles of patients with idiopathic pulmonary fibrosis
K Göktürk, S Macin, B Tülek - 2024
… Idiopathic pulmonary fibrosis (IPF) pathogenesis is still unclear. The aim of this study was to characterize the gut microbiota in … IPF. Further, it is to evaluate the effect of antifibrotic drugs on gut dysbiosis. Twelve patients with IPF using antifibrotic …
- 特発性肺線維症患者の腸内細菌叢プロファイルの調査
LTBP2: A Potential Fibroblasts-Anchoring Target in Idiopathic Pulmonary Fibrosis Regulated by TCF4
L Qiu, G Zhang, X Zhang, Z Xu, S Chen, P Li, C Lu, H Li… - 2024
… Purpose: Idiopathic pulmonary fibrosis(IPF) is a chronic lung disease with unknown cause, characterized by excessive accumulation of … molecular mechanism of LTBP2 in IPF. Methods: GSE122960 single-cell RNA sequencing …
- LTBP2: TCF4 によって制御される特発性肺線維症における線維芽細胞固定標的の可能性
Association between initial treatment response and prognosis in acute exacerbations of idiopathic pulmonary fibrosis treated with steroid pulse therapy
T Sasada, C Shirakawa, K Nagata, R Tachikawa… - 2024
… is recommended for acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF). While previous studies on AE-IPF have focused on steroid … Results: The final analysis included 100 AE-IPF patients treated with steroid pulse therapy. The 28-day …
- ステロイドパルス療法による特発性肺線維症の急性増悪における初期治療反応と予後の関連性
Axatilimab: First Approval
SJ Keam - Drugs, 2024
… other indications, including idiopathicpulmonary fibrosis (IPF) [6]. Axatilimab blocks CSF-1R and reduces levels of circulating proinflammatory and profibrotic monocytes and monocyte-derived macrophages and inhibits the activity of …
- アキサチリマブ：初の承認
Mechanistic Insights into the Treatment of Pulmonary Fibrosis with Bioactive Components from Traditional Chinese Medicine via Matrix Stiffness-Mediated EMT
K Li, H Liu, M Li, M Sun, X Peng, Y Wu, Y Tian, X Liu… - Phytomedicine, 2024
… Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with limited therapeutic options. Our previous research has … Taken together, the findings of this study indicate that ECC-JHF II exerts a therapeutic effect on …
In vitro evaluation of senolytics targeting BCL2 family members to selectively deplete senescent primary human alveolar and small airway-derived epithelial cells
D Schäfer, L Beck, I Christ, V Schröder, E Peter… - 2024
… Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and ultimately fatal lung disease. Aging is a significant risk factor for patients with IPF, making the understanding of aging mechanisms in the lung crucial for addressing the causes of …
- BCL2ファミリーメンバーを標的とした老化細胞除去薬のin vitro評価により、老化したヒト一次肺胞および小気道由来上皮細胞を選択的に除去する
Interstitial lung diseases with concomitant lung cancer: a data mining approach
S Lettieri, F Mariani, L Del Frate, S Mancinelli, D Piloni… - 2024
… idiopathic pulmonary fibrosis (IPF) represents a condition rapidly progressive to respiratory failure and patients’s death. Notably, the incidence of lung cancer (LC) in patients already affected by IPF … patients featuring LC and co-existing IPF. The …
- 肺癌を併発する間質性肺疾患：データマイニングアプローチ
[PDF] Stage-Dependent Fibrotic Gene Profiling of WISP1-Mediated Fibrogenesis in Human Fibroblast
K Singh, M Witek, J Brahmabhatt, K Thirunavukkarasu… - 2024
… Abstract: Idiopathic pulmonary fibrosis(IPF) is the most common interstitial lung disease with unknown etiology, characterized by chronic … from both healthy individuals and IPF patients. Our data demonstrate that WISP1 is upregulated in IPF-lung …
- ヒト線維芽細胞におけるWISP1を介した線維形成の段階依存的線維化遺伝子プロファイリング
24/11/19
Observational Longitudinal Study of Pulmonary Hypertension in West Highland White Terriers Affected With Canine Idiopathic Pulmonary Fibrosis
E Roels, A Fastrès, E Rizzoli, C Clercx, AC Merveille - Journal of Veterinary Internal …, 2024
Canine idiopathic pulmonary fibrosis (CIPF) is a progressive parenchymal lung disease affecting aging West Highland white terriers (WHWTs). Pulmonary hypertension (PH) is a known co-morbidity in WHWTs affected with CIPF …
- 犬特発性肺線維症に罹患したウエストハイランドホワイトテリアの肺高血圧症に関する観察縦断研究
24/11/18
[HTML] The possible role of hypoxia-induced exosomes on the fibroblast metabolism in idiopathic pulmonary fibrosis
N Alvarado-Vasquez, C Rangel-Escareño… - Biomedicine & …, 2024
… Idiopathic pulmonary fibrosis (IPF) has a high incidence and prevalence among patients over 65 years old. While its exact etiology remains unknown, several risk factors have recently been identified. Hypoxia is associated with IPF due … hypoxic …
- 特発性肺線維症における線維芽細胞の代謝に対する低酸素誘発性エクソソームの可能性のある役割
Identification of potential mechanisms of Schisandrin B in the treatment of idiopathic pulmonary fibrosis by integrating network pharmacology and experimental …
T Pan, J Wu, X Qiu, D Zhu, J Wang, T Li, Z Wang… - … -Schmiedeberg's Archives of …, 2024
… Idiopathic pulmonary fibrosis (IPF) is a worsening fibrotic condition characterized by a short … A mouse model of bleomycin-induced pulmonary fibrosis was established, and the modeled … the development of bleomycin-induced pulmonary …
Altered expression of CSF1R in airway macrophages during idiopathic pulmonary fibrosis
C Michalaki, TM Maher, CM Lloyd, PL Molyneaux… - 2024
… BAL) of patients with IPF and predicted survival. However, how the expression of CSF1R is altered during IPF, and how CSF1R influences … of CSF1R in the airways during IPF, we first analysed peripheral blood and bronchoalveolar lavage (BAL) …
- 特発性肺線維症における気道マクロファージの CSF1R 発現の変化
[PDF] Development of Idiopathic Pulmonary Fibrosis and its Pathogenic Inhibition by Drugs: An Overview
AK Mandal
… and / or epithelial damage including idiopathic interstitial pneumonias, and also called IPF [1,2]. As the incidences of IPF are being enhanced … Usual interstitial pneumonia (UIP), the histological counterpart of IPF, is provisionally heterogenous …
- 特発性肺線維症の発症と薬剤によるその発症抑制：概要
[HTML] Exploring the Potential Relationship between Gut Microbiome Metabolites and Idiopathic Pulmonary Fibrosis via Network Pharmacology Study
Z Li, Z Zhu, J Wang, M Zhang, Y Gan, Y Yan, L Wang - Fibrosis, 2024
… does not include information on microbiomes associated with lung fibrotic diseases such as idiopathic pulmonary fibrosis (IPF). The targets of metabolites were derived from previous research [26]. IPF targets were determined using …
Discovery of Selective PDE1 Inhibitors with Anti-pulmonary Fibrosis Effects by Targeting the Metal Pocket
MY Jiang, C Zhang, QH Huang, LL Feng, YY Yang… - Journal of Medicinal …, 2024
… Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with no ideal drugs. Our previous … Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease characterized by … are approximately 3 million IPF patients worldwide, and …
- 金属ポケットを標的とした抗肺線維症効果を持つ選択的PDE1阻害剤の発見
The CX3CL1 Chemokine in Bronchoalvelar Lavage Fluid and its Cellular Sources in Diffuse Parenchymal Lung Diseases
E Tedlova, M Suchankova, J Urban, V Leksa… - 2024
… CX3CL1-CX3CR1 axis in the process of pulmonary fibrosis. In this study, we evaluated the … lavage fluid in sarcoidosis, idiopathicpulmonary fibrosis (IPF), and hypersensitivity pneumonitis (… Results: We found the highest concentration of …
- 気管支肺胞洗浄液中の CX3CL1 ケモカインとびまん性実質性肺疾患におけるその細胞源
Cough Reflex Hypersensitivity as a Key Treatable Trait
WJ Song, DV Manian, Y Kim, M Zhang, AH Morice - The Journal of Allergy and …, 2024
… Morphine for 493 treatment of cough in idiopathic pulmonary fibrosis (PACIFY COUGH): a prospective, 494 multicentre, randomised, double-blind, placebo-controlled, two-way crossover trial. The 495 Lancet Respiratory Medicine 2024; 12:273-80. 60. …
- 咳反射過敏症は治療可能な重要な特性である
THE EFFECT OF TROSİNE KİNASE İNHİBİTOR NİNTEDANİB ON POST-TRAUMATİC PROLİFERATİVE VİTRORETİNOPATHY
S Müftüoğlu
… Nintedanib (BIBF1120) is the first tyrosine kinase inhibitor approved by FDA for treatment of Idiopathic Pulmonary Fibrosis. It is small molecule tyrosine kinase inhibitor that targets PDGF receptor-α and -β, FGF receptor-1–3, VEGF receptor-1–3 …
- 外傷後増殖性硝子体網膜症に対するトロシンキナーゼ阻害剤ニンテダニブの効果
Identification of novel protein drug targets for respiratory diseases by integrating human plasma proteome with GWAS
X Ma, W Ni, Z Gao - 2024
… analyses, including five proteins (NRXN3, NRXN3B, MAPK3, COMMD1, and PRSS27) in relation to chronic obstructive pulmonary disease, three proteins (TEF, CASP8, and IL7R) associated with asthma, and the FUT3_FUT5 linked to idiopathic …
- ヒト血漿プロテオームとGWASの統合による呼吸器疾患に対する新規タンパク質薬物標的の同定
24/11/17
[PDF] Idiopathic pulmonary fibrosis is a risk factor for cardiovascular disease; Potential role for systemic inflammation
MF AbdelGhany, WGE Khaleel, AO Ahmed… - 2024
… idiopathic pulmonary fibrosis. This study aims to: investigate the prevalence and impact of cardiovascular comorbidities in patients with IPF… Methods: This prospective case-control study was performed on 134 idiopathic pulmonaryfibrosis …
- 特発性肺線維症は心血管疾患の危険因子であり、全身性炎症の潜在的な役割がある
A Comparison of Pulmonary Function Test (PFT) Trajectories in Idiopathic Pulmonary Fibrosis (IPF) and Combined Pulmonary Fibrosis and Emphysema (CPFE) …
CC Huntley, P Ellis, S Kanabar, MN Armitage, P Mitra… - 2024
… It is unclear if CPFE is a distinct clinical entity compared to IPF. Aim: To compare PFT parameter trajectories of patients with IPF and CPFE. … Demographic and clinical data were extracted from electronic medical records, with patients grouped …
- 特発性肺線維症（IPF）と肺線維症・肺気腫合併症候群（CPFE）における肺機能検査（PFT）の軌跡の比較
[PDF] Platelet indices and idiopathic pulmonary fibrosis: a multivariable mendelian randomization study
Y Zheng, Y Liang, L Zhu, C Li, N Zang, T Wang, L Pang… - 2024
… Idiopathic pulmonary brosis (IPF) is a chronic, progressive interstitial lung disease characterized by pulmonary brosis of unknown etiology … , and is the most important pathological type in idiopathic interstitial pneumonia [1]. The cognitive rate …
- 血小板指数と特発性肺線維症：多変量メンデルランダム化研究
Early View
M Mondoni, R Rinaldo, CJ Ryerson, C Albrici… - 2024
… Background: Idiopathic pulmonary fibrosis(IPF) is a chronic, … IPF and related pulmonary hypertension (PH), a complication of the disease. Methods: We carried out a non-systematic, narrative literature review aimed at describing the role of …
- 早期の見解
Reproducible lung protective effects of a TGFβR1/ALK5 inhibitor in the bleomycin-induced and spirometry-confirmed mouse model of IPF
AG Petersen, S Korntner, S Pors, HH Hansen, M Feigh - 2024
… antifibrotic drug therapies in preclinical models of idiopathic pulmonary fibrosis (IPF). Here, we compared the therapeutic effects of a TGFβR1/ALK5 inhibitor (ALK5i) in four independent studies in the bleomycin (BLEO)-induced and spirometry-confirmed …
- ブレオマイシン誘発性およびスパイロメトリーで確認されたIPFのマウスモデルにおけるTGFβR1/ALK5阻害剤の再現性のある肺保護効果
Pathological features of connective tissue disease-associated interstitial lung disease in transbronchial cryobiopsies
C Andrew, V Poletti, C Ravaglia, M Radoslav… - HISTOPATHOLOGY, 2024
… usual interstitial pneumonia (UIP) of idiopathic pulmonary fibrosis (IPF), fibrotic hypersensitivity pneumonitis (… IPF or FHP. Results: A non-specific interstitial pneumonia (NSIP) pattern alone was seen in 36 of 120 (30%) CTD-ILD, three of 83 (3.6%) …
- 経気管支凍結生検における結合組織疾患関連間質性肺疾患の病理学的特徴
Development of a multi-biomarker risk score based on serum proteins by the Prognostic Lung Fibrosis Consortium (PROLIFIC)
P Schafer, J Rassa, A Seyda, S Hersey, D Eisinger… - 2024
… has developed a set of well-qualified assays to measure serum proteins linked to prognosis in idiopathic pulmonary fibrosis (IPF). … were measured in serum collected from IPF patients at the time of enrollment (baseline) into the Pulmonary …
- 肺線維症予後コンソーシアム（PROLIFIC）による血清タンパク質に基づくマルチバイオマーカーリスクスコアの開発
Late Breaking Abstract-A deep learning algorithm for predicting progression in fibrosing interstitial lung disease
C Fermoyle, S Walsh, J Mackintosh, X Xing, Y Nan… - 2024
… pulmonary fibrosis. SOFIA (Systematic Objective Fibrotic Imaging Analysis Algorithm) has demonstrated superior prognostic performance compared to manual scoring in idiopathic pulmonary fibrosis (IPF). … SOFIA categorised IPF most often …
[HTML] A novel method for real-time inhalation toxicity assessment in mice using respirometric system: A promising tool for respiratory toxicology
YY Choi, F Hussain, SY Kim, HJ Bae, JY An, HJ Kim… - … and Environmental Safety, 2024
… Furthermore, the present study was also validated in the bleomycin-induced idiopathicpulmonary fibrosis (IPF) model, demonstrating its reliability as a respiratory impairment marker. The results exhibited a strong correlation between …
Air Pollution and Interstitial Lung Disease
YS Jo, JW Song - Tuberculosis and respiratory diseases
… This review article explores the multifaceted relationship between air pollution and interstitial lung diseases (ILDs), particularly focusing on idiopathic pulmonary fibrosis (IPF), the most severe form of fibrotic ILD. Air pollutants are mainly …
- 大気汚染と間質性肺疾患
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特発性肺線維症( idiopathic pulmonary fibrosis (IPF) )関連の学術的情報収集してシェアしています。Google Scholar SearchのUpdateを定期的に掲載しています。GoogleのAIが一定の重み付けはしているとは思いますが、玉石混交です。
当面、毎週アラートの内容をアップしていこうと思います。
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