ChatGPTを活用して業務のAI化を進めています。プロンプトエンジニアリングの専門家です！と、名乗れるレベルではありませんが、かなり色々使いこなしてきています。この１年、病気で失われた能力は、別な能力を発達させる、進化することで生き残っていこうと思います。
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24/07/26
Exploring ABHD5 as a Lipid-Related Biomarker in Idiopathic Pulmonary Fibrosis: Integrating Machine Learning, Bioinformatics, and In Vitro Experiments
Y Liao, X Peng, Y Yang, G Zhou, L Chen, Y Yang, H Li… - Inflammation, 2024
… Recent studies increasingly suggest a connection between lipids and idiopathicpulmonary fibrosis (IPF). This study was aimed at exploring potential lipid-related biomarkers for IPF and uncovering the mechanisms underlying pulmonary fibrosis …
- 特発性肺線維症における脂質関連バイオマーカーとしての ABHD5 の探索: 機械学習、バイオインフォマティクス、および in vitro 実験の統合
[PDF] Sample Size Re-Estimation in an Ongoing Dose-Ranging Study of Nalbuphine Extended-Release for Cough in Idiopathic Pulmonary Fibrosis: The CORAL Study
TM Maher, D Clark, B Neustifter, M Kreuter
… • The SSRE will allow for an appropriately sized study to aid in evaluation of the efficacy and safety of NAL ER for patients with IPF • This study will provide efficacy and safety data to inform determination of optimal doses for phase 3 pivotal studies …
- 特発性肺線維症の咳に対するナルブフィン徐放性製剤の継続中の用量範囲研究におけるサンプルサイズの再推定：CORAL 研究
[HTML] Ancient Wisdom and Modern Innovations: Methods of Administering Healing
AA Kattner - Biomedical Journal, 2024
… Idiopathic pulmonary fibrosis (IPF) may present without symptoms and is diagnosed through exclusion. It is crucial to distinguish it from other interstitial lung diseases to opt for the appropriate therapeutic approach. Bartold et al. critically …
- 古代の知恵と現代の革新：治療を施す方法
24/07/25
Antifibrotic therapy in progressive pulmonary fibrosis: a review of recent advances
M Naqvi, J Hannah, A Lawrence, K Myall, A West… - Expert Review of …, 2024
… Pirfenidone in patients with progressive fibrotic interstitial lung diseases other than idiopathic pulmonary fibrosis (RELIEF): a double-blind, randomized, placebo-controlled, phase 2b trial. Lancet Respir Med [Internet]. 2021 May 1 [cited 2024 Feb 12];9(5):476–86. …
- 進行性肺線維症における抗線維化療法：最近の進歩のレビュー
ER Oxidative Stress Promotes Glutathione-Dependent Oxidation of Collagen-1A1 and Promotes Lung Fibroblast Activation
JE Druso, MB MacPherson, SB Chia, E Elko… - American Journal of …, 2024
… Tissue fibrosis is an underlying component of numerous human diseases, including idiopathicpulmonary fibrosis (IPF). IPF mostly affects … The fibrotic extracellular matrix (ECM) found in IPF provides mechanosignals that promote the …
- ER 酸化ストレスはグルタチオン依存性コラーゲン 1A1 の酸化を促進し、肺線維芽細胞の活性化を促進する
24/07/24
[PDF] Cordyceps sinensis ameliorates idiopathic pulmonary fibrosis in mice via inhibiting mitochondrion‐mediated oxidative stress
Y Zhang, L Zhou, G Cheng, Y Zhou, Q Guo, J Wu… - MedComm–Future Medicine, 2024
… Idiopathic pulmonary fibrosis (IPF) represents a chronic interstitial lung disease with an unclear underlying mechanism and currently lacks … However, the specific role of CS in treating IPF remains unclear. In this study, we aimed to assess the …
[PDF] Immunological Evaluation of TGF-β and Osteopontin of Idiopathic Pulmonary Fibrotic patients in Al-Diwaniyah province
MH Hasan, AM Hasoon
… Dysregulated immune responses and imbalanced processes of injury, inflammation, and repair are key factors in initiating and advancing idiopathic pulmonary fibrosis. The guiding arm of the immunity system productions vital parts in …
- ディワニヤ県の特発性肺線維症患者のTGF-βとオステオポンチンの免疫学的評価
Fibroblast activation protein is a cellular marker of fibrotic activity in canine idiopathic pulmonary fibrosis
E Rizzoli, C de Meeûs d'Argenteuil, A Fastrès, E Roels… - Frontiers in Veterinary Science
… Canine idiopathic pulmonary fibrosis(CIPF) is a progressive fibrotic interstitial lung disease of unknown etiology, afflicting aging West … Fibroblast activation protein (FAP), a protease overexpressed in many cancers, is upregulated in …
- 線維芽細胞活性化タンパク質は、犬の特発性肺線維症における線維化活性の細胞マーカーである。
[PDF] CELLULAR AND MOLECULAR GENETIC MECHANISMS OF LUNG FIBROSIS DEVELOPMENT AND THE ROLE OF VITAMIN D
D Enzel, M Kriventsov, T Sataieva, V Malygina - 2024
… Abstract: Idiopathic pulmonary fibrosisremains a relevant problem in the field of healthcare with an unfavorable prognosis for patients due to progressive fibrous remodeling of the pulmonary parenchyma. Starting with the reactions damaging the …
Primer on Fibroblast Growth Factor 7 (FGF 7)
Y Zheng, WH Liu, B Yang, IM Krentsis - Differentiation, 2024
… in pulmonary parenchymal and vascular remodeling in idiopathic pulmonary arterial hypertension (IPAH) or idiopathic pulmonaryfibrosis (IPF). While comparing to healthy lungs, significant upregulation of FGF7 expression was found in IPAH and …
- 線維芽細胞増殖因子 7 (FGF 7) の入門
24/07/23
Synergistic Treatment Approach for Pulmonary Fibrosis: Prednisone and Cyclophosphamide Regulation of Circular RNA MORF4L1 and MicroRNA-29a-3p Targeting …
D Wang, H Zhao, B Li, F Quan - Iranian Journal of Allergy, Asthma and Immunology, 2024
This study aimed to explore the effect of prednisone (PDN) combined with cyclophosphamide (CTX) on bleomycin-induced pulmonary fibrosis (PF) in rats via circular RNA mortality factor 4 like 1 (MORF4L1)/microRNA (miR)-29a-3p/Bromodomain …
[HTML] CD206+ macrophages are relevant non-invasive imaging biomarkers and therapeutic targets in experimental lung fibrosis
L Pommerolle, G Beltramo, L Biziorek, M Truchi… - Thorax, 2024
… Background Interstitial lung diseases (ILDs) include a large number of diseases associated with progressive pulmonary fibrosis (PPF), including idiopathic pulmonary fibrosis (IPF). Despite the rarity of each of the fibrotic ILDs individually …
- CD206+マクロファージは、実験的肺線維症における非侵襲的イメージングバイオマーカーおよび治療標的として重要である。
24/07/22
[HTML] Causal relationship between gut microbiota and idiopathic pulmonary fibrosis: A two-sample Mendelian randomization
S Fan, B Xue, J Ma - Medicine, 2024
… (GM) and Idiopathic pulmonary fibrosis(IPF), we performed a two-sample Mendelian randomization (MR). GM was used as an exposure factor, and instrumental variables were determined from the GWAS of 18,340 participants …
- 腸内細菌叢と特発性肺線維症の因果関係：2標本のメンデルランダム化
[HTML] … for the Incidence of Severe Radiation Pneumonitis Following Radiotherapy in Non-Small Cell Lung Cancer Patients with Underlying Idiopathic Pulmonary Fibrosis
J Hwang, H Kim, SM Kim, DS Yang - Life, 2024
… Background: Idiopathic pulmonary fibrosis(IPF) has the potential to cause fatal pulmonary toxicity after radiotherapy and can … IPF and are treated with radiotherapy. Methods: We retrospectively reviewed the medical records of 19 …
Identification of a fibronectin-binding protein signature associated with idiopathic pulmonary fibrosis
Y Sun, B King, AJ Hamlin, M Saniepay, K Gorshkov… - Cells & Development, 2024
… Normal human lung fibroblasts (NHLF, Lonza CC-2512) and diseased human lung fibroblasts from idiopathic pulmonary fibrosis patients (DHLF, Lonza CC-7231) were cultured in complete medium, FGM-2 Fibroblast Growth Medium-2 BulletKit (Lonza …
- 特発性肺線維症に関連するフィブロネクチン結合タンパク質シグネチャの特定
Use of Pirfenidone in Fibrotic Interstitial Lung Diseases and Beyond: a Review
H Mingfeng - Frontiers in Medicine
… in idiopathic pulmonary fibrosis (IPF), implying the potential for shared therapeutic approaches. Pirfenidone exhibits antifibrotic and anti-inflammatory properties, making it the first small-molecule drug approved for treating IPF. Pirfenidone has …
- 線維性間質性肺疾患およびそれ以降の疾患におけるピルフェニドンの使用: レビュー
[HTML] The role of pathologists in the diagnosis of occupational lung diseases: an expert opinion of the European Society of Pathology Pulmonary Pathology Working Group
F Calabrese, M Montero-Fernandez, I Kern, F Pezzuto… - Virchows Archiv, 2024
… The presence of UIP should alert the pathologist to a causation other than asbestos, such as idiopathic pulmonary fibrosis, chronic hypersensitivity pneumonitis, or collagen vascular disease. The asbestos body count requires the presence of two …
- 職業性肺疾患の診断における病理学者の役割：欧州病理学会肺病理学ワーキンググループの専門家意見
24/07/21
[HTML] Identification of risk factors for acute exacerbation of idiopathic pulmonary fibrosis based on baseline high-resolution computed tomography: a prospective …
Z Wang, Z Zhang, L Zhu, J Hou, H Fu, X Yang, F Wang… - BMC Pulmonary Medicine, 2024
… This study aimed to investigate risk factors for acute exacerbation of idiopathic pulmonaryfibrosis (AE-IPF) based on baseline high-… of IPF patients may suffer intermittent acute respiratory aggravation for idiopathic factor or triggers–termed “acute …
- ベースライン高解像度コンピュータ断層撮影に基づく特発性肺線維症の急性増悪の危険因子の特定：前向き観察研究
Macrophage polarization and its impact on idiopathic pulmonary fibrosis
Z Ge, Y Chen, L Ma, F Hu, L Xie - Frontiers in Immunology
… Idiopathic pulmonary fibrosis (IPF) is a lung disease that worsens over time, causing fibrosis in the lungs and ultimately resulting in … the development of IPF. Recent research has indicated that the polarization of macrophages is crucial in the …
- マクロファージの極性化と特発性肺線維症への影響
Metabolic Profiling of Idiopathic Pulmonary Fibrosis in a Mouse Model: Implications for Pathogenesis and Biomarker Discovery
YZ Zhang, XJ Jia, WJ Xu, XQ Ding, XM Wang, X Chi… - Frontiers in Medicine
… triggers of idiopathic pulmonary fibrosis(IPF), but our lack of a comprehensive understanding of this process has hampered the development of IPF-… In conclusion, the serum metabolic disorders found to be associated with pulmonary …
- マウスモデルにおける特発性肺線維症の代謝プロファイリング：病因とバイオマーカー発見への影響
[HTML] Pathological mechanisms and novel drug targets in fibrotic interstitial lung disease
Y Nishioka, J Araya, Y Tanaka, A Kumanogoh - Inflammation and Regeneration, 2024
… PF genetic and/or other familial pulmonaryfibrosis, HP hypersensitivity pneumonitis, ILD interstitial lung disease, iNSIP idiopathicnonspecific interstitial pneumonia, IPAF interstitial pneumonia with autoimmune features, IPF idiopathic …
- 線維性間質性肺疾患の病理学的メカニズムと新規薬剤ターゲット
Isolation, Structure Elucidation, and Biological Activity of the Selective TACR2 Antagonist Tumonolide and its Aldehyde from a Marine Cyanobacterium
S Kokkaliari, L Grauso, A Mangoni, G Seabra, VJ Paul… - Chemistry (Weinheim an der …
… RNA sequencing upon treatment of HCT116 colorectal cancer cells demonstrated activation of the pulmonary fibrosis idiopathic signaling pathway and the insulin secretion signaling pathway at 20 μM, indicating its potential to modulate these pathways. …
24/07/20
[HTML] Blood lipid profiles as a prognostic biomarker in idiopathic pulmonary fibrosis
JH Oh, G Chae, JW Song - Respiratory Research, 2024
… of lipid metabolism is implicated in the pathogenesis of idiopathic pulmonary fibrosis(IPF). However, the association between the blood lipid profiles and the prognosis of IPF is not well defined. We aimed to identify the impacts of lipid profiles …
- 特発性肺線維症の予後バイオマーカーとしての血中脂質プロファイル
[HTML] Regulation of myofibroblast dedifferentiation in pulmonary fibrosis
X Ju, K Wang, C Wang, C Zeng, Y Wang, J Yu - Respiratory Research, 2024
… Numerous studies on treatment for idiopathicpulmonary fibrosis (IPF) focus on inhibiting the TGF-β pathway, including antagonizing TGF-β, inhibiting Smad2/3 phosphorylation, and activating Smad7 [39]. Research on myofibroblast …
- 肺線維症における筋線維芽細胞の脱分化の制御
[PDF] SIRT5-mediated desuccinylation prevents mitochondrial dysfunction in Alveolar epithelial cells senescence and Pulmonary fibrosis
W Hou, Y Zhao, F Li, Z Guo, L Yang, C Duan, L Gao… - 2024
… Background Senescence of alveolar epithelial cells (AEC) is a key event in the occurrence and development of Idiopathic pulmonary fibrosis(IPF). The pathogenic mechanisms that underlie the effects of AEC senescence remain largely unexplained …
[PDF] Prevalence of distress and changes over time among patients with progressive fibrosing interstitial lung disease
T Yamada, K Sugano, K Matsuno, S Hotta, M Fujii… - 2024
… symptom changes over a one-year period in patients with idiopathic pulmonary brosis (IPF) and those with other PF-ILDs (non-IPF). … to be worse in patients with IPF and cough in non-IPFpatients, and QOL was temporarily worse in non-IPF …
- 進行性線維化性間質性肺疾患患者における苦痛の有病率と経時的変化
Exploring the Effects of Saorilao-4 on the Gut Microbiota of Pulmonary Fibrosis Model Rats Based on 16S rRNA Sequencing
X Song, X Fu, S Niu, P Wang, J Qi, S Shi, H Chang… - Journal of Applied …, 2024
… Impact statement: This study offers new insights into the composition and function of the gut microbiota in pulmonary fibrosis 24 (PF). It also … Allogeneic human mesenchymal stem cells in patients with idiopathic 442 pulmonaryfibrosis via …
- 16S rRNA 配列に基づく肺線維症モデルラットの腸内細菌叢に対する Saorilao-4 の効果の調査
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特発性肺線維症( idiopathic pulmonary fibrosis (IPF) )関連の学術的情報収集してシェアしています。Google Scholar SearchのUpdateを定期的に掲載しています。GoogleのAIが一定の重み付けはしているとは思いますが、玉石混交です。
当面、毎週アラートの内容をアップしていこうと思います。
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