ChatGPTを活用して業務のAI化を進めています。プロンプトエンジニアリングの専門家です！と、名乗れるレベルではありませんが、かなり色々使いこなしてきています。この１年、病気で失われた能力は、別な能力を発達させる、進化することで生き残っていこうと思います。
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23/09/02
Investigating the role of platelets and platelet-derived transforming growth factor-β in idiopathic pulmonary fibrosis
DLW Chong, TA Mikolasch, J Sahota, C Rebeyrol… - American Journal of …, 2023
… Transforming growth factor-β1 (TGFβ1) is the key pro-fibrotic cytokine in idiopathicpulmonary fibrosis 34 (IPF), but the primary source of this cytokine in this disease is … lung interstitium (1), with idiopathic pulmonaryfibrosis (IPF) …
- 特発性肺線維症における血小板および血小板由来トランスフォーミング成長因子βの役割の研究
Analysis of tissue lipidomics and computed tomography pulmonary fat attenuation volume (CTPFAV) in idiopathic pulmonary fibrosis
M O'Callaghan, J Duignan, EJ Tarling, DK Waters… - Respirology (Carlton, Vic.)
… with evidence of lipid deposition in idiopathicpulmonary fibrosis (IPF) histological specimens. The aim of this study was to identify measurable markers of pulmonary lipid that may have utility as IPF biomarkers. Study design and methods: IPF and …
- 特発性肺線維症における組織リピドミクスとコンピュータ断層撮影による肺脂肪減衰量（CTPFAV）の分析
[HTML] Dexmedetomidine alleviates pulmonary fibrosis through the ADORA2B-Mediated MAPK signaling pathway
X Lai, Y Lin, S Huang, L Pu, Q Zeng, Z Wang, W Huang - Respiratory Research, 2023
… Idiopathic pulmonary fibrosis (IPF) is a chronically progressive fibrotic pulmonary disease characterized by an uncertain etiology, a poor prognosis, and a paucity of efficacious treatment options. Dexmedetomidine (Dex), an anesthetic-sparing alpha-2 …
- デクスメデトミジンは、ADORA2B媒介MAPKシグナル伝達経路を通じて肺線維症を軽減
Sinomenine attenuates pulmonary fibrosis by downregulating TGF-β1/Smad3, PI3K/Akt and NF-κB signaling pathways
F Yao, M Xu, L Dong, X Shen, Y Shen, Y Jiang, T Zhu… - 2023
… Idiopathic pulmonary fibrosis (IPF) is a chronic progressive and irreversible interstitial lung disease. Pulmonary fibrosis (PF) has become … Idiopathic pulmonary fibrosis (IPF) is the most common form of PF, with a median survival time …
- シノメニンは、TGF-β1/Smad3、PI3K/Akt、およびNF-κBシグナル伝達経路をダウンレギュレートすることにより肺線維症を軽減
Role of MMP19 in endothelial-to-mesenchymal transition and pulmonary fibrosis
W Zhao, L Wang, J Yang, X Chen, X Guo, K Xu… - 2023
… Idiopathic pulmonary fibrosis (IPF) is a progressive, deadly lung disease. The matrix metalloproteinase enzyme MMP19 has elevated expression in IPF-… They found that MMP19 expression was higher in the lung endothelial cells of IPF patients …
- 内皮間葉移行および肺線維症におけるMMP19の役割
Decline in forced vital capacity as a surrogate for mortality in patients with pulmonary fibrosis
TM Maher, S Stowasser, F Voss, E Bendstrup… - Respirology (Carlton, Vic.)
… We used data from trials of nintedanib in subjects with pulmonary fibrosis to assess decline in forced vital capacity (FVC) as a surrogate for … trials in subjects with idiopathicpulmonary fibrosis, other forms of progressive pulmonary fibrosis …
- 肺線維症患者の死亡率の代用としての努力肺活量の低下
Transcriptomic analysis reveals tumor microenvironment plays important role in nodal metastasis of papillary microcarcinomas
M Kim, S Ryang, SJ Kim, KC Hwa, KB Hyun - Endocrine Abstracts, 2023
… Functional enrichment analysis showed that DEGs were mainly enriched in the pulmonaryfibrosis idiopathic signaling pathway, TME pathway, wound healing signaling pathway, and inhibition of matrix metalloproteases, and the activation of …
- トランスクリプトーム解析により、腫瘍微小環境が乳頭状微小癌のリンパ節転移に重要な役割を果たしていることが判明
Systemic Determinants of Exercise Intolerance in Patients With Fibrotic Interstitial Lung Disease and Severely Impaired DLCO
RM Smyth, MD James, SG Vincent, KM Milne… - Respiratory Care, 2023
… Since smoking is highly prevalent in patients with IPF and other fibrotic ILDs,1,2 we did not … radiographic abnormalities consistent with combined pulmonary fibrosis and emphysema. Twenty… in spontaneously breathing patients with …
- 線維性間質性肺疾患および重度障害のあるDLCO患者における運動不耐症の全身的決定因子
23/08/31
[HTML] Prognostic Value of Serum Biomarkers in Patients with Idiopathic Pulmonary Fibrosis in Relation to Disease Progression
K Domvri, I Organtzis, A Apostolopoulos, E Fouka… - Journal of Personalized …, 2023
… Background: The aim of this present study was to determine serum biomarker levels and their correlation with respiratory function and the clinical course of patients with idiopathicpulmonary fibrosis (IPF). Materials and Methods: This study …
- 疾患進行に関連した特発性肺線維症患者における血清バイオマーカーの予後価値
Oncogenic signaling in idiopathic pulmonary fibrosis
HM Ulke - 2023
… of IPF and NSCLC by analyzing patterns of gene expression alterations and to further characterize the role of candidate genes in the pathogenesis of IPF. … In summary, we demonstrated a pathogenic link between IPF and NSCLC, which …
- 特発性肺線維症における発がん性シグナル伝達
[PDF] Short Notes on DNA Methylation and Importance of Precision Medicine for Idiopathic Pulmonary Fibrosis
G Tortora - 2023
… Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease with unknown etiology that leads to the formation of scar … to the pathogenesis of pulmonaryfibrosis. Endophenotypes underlying the development of idiopathic …
- DNAメチル化と特発性肺線維症に対する精密医療の重要性に関する短いメモ
[PDF] Usefulness of transbronchial lung cryobiopsy when choosing treatment for chronic fibrosing interstitial lung disease: Descriptive research
M Takatsuka, H Yamakawa, T Takemura, S Sato… - 2023
… The most common of these conditions is idiopathic pulmonary brosis (IPF). In addition, idiopathic brotic nonspeci c interstitial pneumonia (… Recently a clinical trial reported a bene cial effect of an anti- brotic agent in ILDs other than IPF that …
- 慢性線維化間質性肺疾患の治療法を選択する際の経気管支肺凍結生検の有用性：記述研究
[HTML] SIgA in various pulmonary diseases
X Wang, J Zhang, Y Wu, Y Xu, J Zheng - European Journal of Medical Research, 2023
… SIgA and idiopathic pulmonary fibrosisIdiopathic pulmonary fibrosis (IPF) is the most common disease in idiopathic interstitial pneumonia. It has a poor prognosis and is a fatal respiratory disease [79], characterized by excessive deposition of …
- さまざまな肺疾患におけるSIgA
Pulmonary Disease
SA Whittaker Brown, SS Braman - Geriatric Medicine: A Person Centered Evidence …, 2023
… The main chronic lung diseases seen in the elderly population are asthma, chronic obstructive pulmonary disease, and interstitial lung disease such as idiopathic pulmonaryfibrosis (IPF). Optimal management of chronic diseases in the …
- 肺疾患
[HTML] Protein Phosphatase 2A as a Therapeutic Target in Pulmonary Diseases
H Yu, S Zaveri, Z Sattar, M Schaible, B Perez Gandara… - Medicina, 2023
… , and idiopathic pulmonary fibrosis. Loss of PP2A responses is linked to many mechanisms associated with disease progressions, such as senescence, proliferation, inflammation, corticosteroid resistance, enhanced protease responses …
- 肺疾患の治療標的としてのプロテインホスファターゼ2A
23/08/29
Emerging opportunities to treat idiopathic pulmonary fibrosis: Design, discovery, and optimizations of small-molecule drugs targeting fibrogenic pathways
W Luo, Y Gu, S Fu, J Wang, J Zhang, Y Wang - European Journal of Medicinal …, 2023
… Idiopathic pulmonary fibrosis (IPF) is the most common fibrotic form of idiopathic diffuse lung disease. Due to limited treatment options, IPF patients suffer from poor survival. About ten years ago, Pirfenidone (Shionogi, 2008; InterMune, 2011) and …
- 特発性肺線維症を治療する新たな機会：線維形成経路を標的とした小分子薬の設計、発見、最適化
[PDF] HSP47: A Therapeutic Target in Pulmonary Fibrosis
N Sakamoto, D Okuno, T Tokito, H Yura, T Kido… - Biomedicines, 2023
… Abstract: Idiopathic pulmonary fibrosis(IPF) is a chronic lung disease characterized by a progressive decline in lung function and poor prognosis. The deposition of the extracellular matrix (ECM) by myofibroblasts contributes to the …
- HSP47：肺線維症の治療標的
[HTML] Acute exacerbation of idiopathic pulmonary fibrosis treated using the Feibi recipe: Two case reports
ZH Liu, GD Li, QX Hao, F Cao, Y Cheng, MJ Kou… - World Journal of Clinical …, 2023
… Core Tip: In this report, we present the cases of two patients diagnosed with idiopathicpulmonary fibrosis with progressive fibrosing who received traditional Chinese medicine (TCM). The disease progression slowed down, and the symptoms …
- 特発性肺線維症の急性増悪をフェイビレシピで治療：2件の症例報告
Acute Exacerbation and Proposed Criteria for Progressive Pulmonary Fibrosis in Patients with Fibrotic Hypersensitivity Pneumonitis and Idiopathic Pulmonary Fibrosis …
R Okuda, T Takemura, T Misumi, R Nagasawa… - … ; International Review of …, 2023
… HP with that of idiopathic pulmonaryfibrosis (IPF). Consecutive patients with pathologically confirmed fibrotic HP and IPFdiagnosed based on a multidisciplinary discussion were included in the analysis. AE in patients with fibrotic HP and IPF was …
- 線維性過敏性肺炎および特発性肺線維症患者における急性増悪および進行性肺線維症の提案された基準。
[HTML] Feasibility of a Telehealth-Delivered Breathing Intervention for Patients With Idiopathic Pulmonary Fibrosis
A Carlson - 2023
… Idiopathic pulmonary fibrosis (IPF) is a debilitating chronic lung disease that affects approximately 100,000 individuals in the United States (US), with 30,000 to 40,000 new cases diagnosed each year. Dyspnea is experienced by 90% of …
- 特発性肺線維症患者に対する遠隔医療による呼吸介入の実現可能性
Dynamic Atlas of Immune Cells Reveals Multiple Functional Features of Macrophages Associated with Progression of Pulmonary Fibrosis
J Zhang, J Lv, H Gao, J Ma, J Liu, Y Tian, C Yang, M Li… - Frontiers in Immunology
… Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease with a high mortality rate and … induced pulmonaryfibrosis—a classical mouse model that mimics human IPF. The results revealed distinct components of immune cells in …
- 免疫細胞の動的アトラスは、肺線維症の進行に関連するマクロファージの複数の機能的特徴を明らかに
Acute exacerbation of fibrotic interstitial lung diseases.
N Hoyer, E Bendstrup, JR Davidsen, TK Lund… - Ugeskrift for Laeger, 2023
… Acute exacerbation of idiopathic pulmonaryfibrosis (AE-IPF) and other fibrotic interstitial lung diseases (AE-ILD) is defined by significant acute … The diagnosis of AE-IPF and AE-ILD is based on typical HRCT findings of new and bilateral ground …
- 線維性間質性肺疾患の急性増悪
[PDF] Changes in lung epithelial cell volatile metabolite profile induced by pro-fibrotic stimulation with TGF-β1.
C Hayton, W Ahmed, P Cunningham, K Piper-Hanley… - Journal of Breath Research, 2023
… We identified VOCs in the headspace of two lung cell lines used to model pulmonaryfibrosis: alveolar … Towards personalized medicine in idiopathic pulmonary fibrosis by screening exhaled volatiles in patients’ primary bronchial …
- TGF-β1による前線維化刺激によって誘発される肺上皮細胞の揮発性代謝産物プロファイルの変化。
Screening, diagnosis, and monitoring of interstitial lung disease in autoimmune rheumatic diseases: A narrative review
SD Good, JA Sparks, ER Volkmann - Revista Colombiana de Reumatología, 2023
… In 2023, an international clinical practice guideline defined PPF as an individual with ILD (other than idiopathic pulmonary fibrosis [IPF]) who experiences at least two of the following three criteria within the past year, not attributable to an alternate …
- 自己免疫性リウマチ性疾患における間質性肺疾患のスクリーニング、診断、モニタリング：ナラティブレビュー
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特発性肺線維症( idiopathic pulmonary fibrosis (IPF) )関連の学術的情報収集してシェアしています。Google Scholar SearchのUpdateを定期的に掲載しています。GoogleのAIが一定の重み付けはしているとは思いますが、玉石混交です。
当面、毎週アラートの内容をアップしていこうと思います。
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